Obesity-Related Chronic Kidney Disease: From Diagnosis to Treatment
Diagnostics,
Год журнала:
2025,
Номер
15(2), С. 169 - 169
Опубликована: Янв. 14, 2025
Obesity
has
emerged
as
a
global
epidemic
with
far-reaching
health
complications,
including
its
role
an
independent
risk
factor
for
chronic
kidney
disease
(CKD).
Increasing
evidence
suggests
that
obesity
contributes
to
CKD
through
multiple
mechanisms,
inflammation,
hemodynamic
alterations,
insulin
resistance,
and
lipid
accumulation.
These
processes
can
culminate
in
histopathological
changes
collectively
referred
obesity-related
glomerulopathy
(ORG).
This
review
aims
provide
comprehensive
overview
of
the
current
knowledge
regarding
prevalence,
clinical
manifestations,
pathophysiology
ORG.
Furthermore,
we
emphasize
importance
identifying
key
biomarkers
facilitate
early
detection
Finally,
explore
emerging
therapeutic
strategies
offer
promise
mitigating
this
growing
crisis.
Язык: Английский
Elevated GFI1 in Alveolar Macrophages Suppresses ACOD1 Expression and Exacerbates Lipopolysaccharide‐Induced Lung Injury in Obesity
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 8, 2025
To
investigate
the
mechanisms
behind
worsening
of
acute
lung
injury
(ALI)
in
obesity,
transcriptomic
sequencing
is
performed,
and
significantly
reduced
mRNA
levels
Aconitate
Decarboxylase
1
(ACOD1)
tissue
high-fat
diet
(HFD)
mice
are
found.
Clinical
samples
collected,
an
ALI
model
established
HFD
mice,
both
human
mouse
analyzed,
revealing
a
significant
decrease
ACOD1
expression
alveolar
macrophages
obesity.
Further
vivo
vitro
experiments
show
that
knockdown
worsens
injury,
inflammation,
oxidative
stress,
while
overexpression
alleviates
these
effects.
Moreover,
nuclear
factor
erythroid
2-related
2
(Nrf2)
inhibition
diminishes
protective
effects
exacerbated
by
Additionally,
context
growth
independent
(GFI1)
protein
elevated
macrophages,
its
leads
to
upregulated
expression.
Therefore,
this
study
suggests
downregulation
key
likely
driven
GFI1
upregulation.
Язык: Английский
The Many Facets of PPAR-γ Agonism in Obesity and Associated Comorbidities: Benefits, Risks, Challenges, and Future Directions
Current Obesity Reports,
Год журнала:
2025,
Номер
14(1)
Опубликована: Фев. 12, 2025
Язык: Английский
Beneath the Surface: The Emerging Role of Ultra-Processed Foods in Obesity-Related Cancer
Current Oncology Reports,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 27, 2025
Abstract
Purposeof
Review
Ultra-processed
foods
(UPFs)
are
becoming
more
and
important
in
daily
diets
around
the
world;
some
cases,
they
can
account
for
as
much
60%
of
energy
intake.
Epidemiological
evidence
suggests
that
this
shift
toward
high
levels
food
processing
may
be
partially
responsible
global
obesity
epidemic
rise
prevalence
chronic
diseases.
Recent
Findings
Few
prospective
studies
have
examined
relationship
between
UPF
consumption
cancer
outcomes.
According
to
currently
available
information,
UPFs
increase
risk
due
their
obesogenic
properties
exposure
substances
cause
cancer,
such
certain
additives
pollution
from
product
processing.
The
complex
involves
factors
immune
dysregulation,
altered
adipokine
sex
hormone
levels,
abnormal
fatty
acid
metabolism,
extracellular
matrix
remodeling,
inflammation.
Addressing
associated
with
could
involve
a
multifaceted
approach,
including
consumer
behavior
modification
programs
robust
public
health
regulations
aimed
at
enhancing
environments.
Improved
knowledge
potential
dual
negative
impacts
on
environment
is
one
priority
areas
we
identify
future
research
policy
implications.
Various
approaches
used
prevent
cancers
consumption,
change
stricter
needed
improve
environment.
Summary
This
review
examines
first
time
role
obesity,
exploring
underlying
biological
mechanisms
identifying
key
action,
environmental
impact
UPFs.
Язык: Английский
Total Hip Arthroplasty in Post-Bariatric Surgery Patients: Increased Risks and Economic Burden?
Healthcare,
Год журнала:
2025,
Номер
13(8), С. 887 - 887
Опубликована: Апрель 12, 2025
Background:
THA
is
a
widely
performed
surgical
procedure
that
improves
mobility
and
quality
of
life
in
patients
with
hip
joint
diseases.
The
increasing
prevalence
obesity
has
led
to
rise
the
number
undergoing
following
bariatric
surgery.
This
study
investigates
trends
among
history
surgery,
comparing
demographics,
hospitalization
metrics,
post-operative
complications,
overall
outcomes
those
without
such
history.
Methods:
Using
NIS
database
(2016–2019),
we
analyzed
cohort
1,496,809
patients,
including
20,429
Propensity
score
matching
was
employed
control
for
confounding
factors,
resulting
matched
each
group.
Statistical
analyses
compared
demographic
characteristics,
comorbidities,
outcomes,
significance
threshold
p
<
0.05.
Results:
proportion
prior
surgery
increased
significantly
between
2016
2019
(p
0.01).
Compared
these
were
younger
(60.3
vs.
66.0
years,
0.01)
predominantly
female
(75.0%
55.5%,
After
PSM,
had
shorter
hospital
stay
(2.17
2.37
days,
=
0.027)
but
incurred
higher
charges
($63,631
$62,883,
Post-operative
complications
this
group,
risks
dislocation
(RR
4.0,
95%
CI:
3.4–4.8,
0.01),
site
infection
2.0,
1.8–2.4,
pneumonia
2.5,
2.1–2.8,
intraoperative
fracture
1.6,
1.3–2.0,
Conclusions:
rising
post-bariatric
highlights
need
optimized
perioperative
care.
Despite
stays,
face
complication
risks,
requiring
tailored
management.
Further
research
should
explore
alternative
weight
management
strategies
improve
outcomes.
Язык: Английский
Kidney Damage in Pediatric Obesity: Insights from an Emerging Perspective
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(23), С. 7025 - 7025
Опубликована: Ноя. 21, 2024
The
role
of
obesity
as
a
risk
factor
for
chronic
kidney
disease
(CKD)
in
adulthood
has
been
well
established.
Over
the
last
years,
damage
(KD)
emerged
significant
consequence
since
childhood.
Indeed,
complex
interplay
metabolic
factors,
including
insulin
resistance
(IR),
hypertension,
oxidative
stress,
adipose
tissue
dysfunction,
and
systemic
inflammation,
might
affect
renal
hemodynamics,
contributing
to
CKD
development
over
time
at-risk
young
patients.
As
prevalence
pediatric
continues
rise
globally,
understanding
implications
health
terms
early
intervention
is
paramount
importance.
Careful
monitoring
function
within
multidisciplinary
approach
children
with
crucial
detecting
KD,
allowing
timely
lifestyle
modifications
treatment.
In
this
framework,
continued
research
essential
further
elucidate
mechanisms
linking
KD
explore
not
only
effective
preventive
strategies
but
also
long-term
impact
on
obesity.
Given
intimate
link
milieu
obesity,
we
aimed
provide
comprehensive
insightful
overview
its
by
reviewing
most
recent
literature
field.
Язык: Английский
From Adipose to Ailing Kidneys: The Role of Lipid Metabolism in Obesity-Related Chronic Kidney Disease
Antioxidants,
Год журнала:
2024,
Номер
13(12), С. 1540 - 1540
Опубликована: Дек. 16, 2024
Obesity
has
emerged
as
a
significant
public
health
crisis,
closely
linked
to
the
pathogenesis
and
progression
of
chronic
kidney
disease
(CKD).
This
review
explores
intricate
relationship
between
obesity-induced
lipid
metabolism
disorders
renal
health.
We
discuss
how
excessive
free
fatty
acids
(FFAs)
lead
accumulation
in
tissues,
resulting
cellular
lipotoxicity,
oxidative
stress,
inflammation,
ultimately
contributing
injury.
Key
molecular
mechanisms,
including
roles
transcriptional
regulators
like
PPARs
SREBP-1,
are
examined
for
their
implications
dysregulation.
The
also
highlights
impact
glomerular
tubular
overload
on
pathology,
emphasizing
podocytes
cells
maintaining
function.
Various
therapeutic
strategies
targeting
metabolism,
pharmacological
agents
such
statins
SGLT2
inhibitors,
well
lifestyle
modifications,
discussed
potential
mitigate
CKD
obese
individuals.
Future
research
directions
suggested
better
understand
mechanisms
linking
develop
personalized
approaches.
Ultimately,
addressing
obesity-related
may
enhance
improve
outcomes
individuals
suffering
from
CKD.
Язык: Английский
The role of kidney biopsy in deciphering diabetic versus non-diabetic origin of kidney disease among patients with type 2 diabetes mellitus and nephrotic range proteinuria: A retrospective study
Metabolism Open,
Год журнала:
2024,
Номер
23, С. 100313 - 100313
Опубликована: Авг. 28, 2024
Diabetes
mellitus
(DM)
is
tightly
associated
with
the
increased
prevalence
of
diabetic
kidney
disease
(DKD).
Nonetheless,
severe
renal
function
impairment
and/or
nephrotic
range-proteinuria
could
also
result
from
non-diabetic
(non-DRD)
among
patients
DM.
The
'Gold
standard'
for
differential
diagnosis
between
DKD
and
non-DRD
biopsy,
although
no
real
consensus
exists.
Thus,
this
study
intends
to
associate
clinical
biochemical
profile
DM
histopathological
data
biopsy.In
addition,
we
aimed
evaluate
role
especially
when
other
causes,
than
DM,
are
highly
suspected
disease.
Язык: Английский