Noninvasive tests and diagnostic pathways to MASH diagnosis in the United States: a retrospective observational study

Journal of Medical Economics, Год журнала: 2025, Номер unknown, С. 1 - 12

Опубликована: Фев. 18, 2025

Aim Although liver biopsy is considered the most reliable diagnostic tool for metabolic dysfunction–associated steatohepatitis (MASH), it invasive and can be costly. Clinicians are increasingly relying on routine biomarkers other noninvasive tests (NITs) diagnosis. We examined real-world pathways patients newly diagnosed with MASH a primary focus NITs.

Язык: Английский

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Advancing Obesity Management: the Very Low-Energy Ketogenic therapy (VLEKT) as an Evolution of the “Traditional” Ketogenic Diet

Current Obesity Reports, Год журнала: 2025, Номер 14(1)

Опубликована: Апрель 3, 2025

This narrative review comprehensively analyzes VLEKT as an advanced nutritional strategy for obesity management. The focus is on the beneficial effects key disease organs, such adipose tissue and liver, well modulation of intestinal permeability its fundamental role in influencing gut microbiota inflammatory pathways. impact obesity-related comorbidities, including metabolic syndrome, cardiovascular disease, endocrine disorders, dysfunction-associated steatotic liver (MASLD), neurological kidney alterations, also investigated. Moreover, to assess wider application treatment, combination ketogenic regimes with additional strategies physical activity, bariatric surgery, digital health technologies examined. Despite promising clinical results, adherence potential deficiencies require careful follow-up individualized programming monitored by specialists. Future research should elucidating molecular mechanisms underlying physiological systems, long-term safety. Nevertheless, innovative approach offering a target-oriented highly effective people fighting against overweight associated medical complications. Obesity multifactorial chronic numerous comorbidities; given increasing prevalence, personalized intervention are crucial inhibit "obesity pandemic" according "food re-educational" protocol. Among dietary interventions, diet (KD) has attracted attention effectiveness weight management benefits. A variant, very low-calorie (VLCKD), more recently defined low-energy (VLEKD), combines benefits ketosis substantial calorie restriction, improving overall health.

Язык: Английский

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The Impact of Dietary Interventions on Metabolic Outcomes in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Comorbid Conditions, Including Obesity and Type 2 Diabetes

Nutrients, Год журнала: 2025, Номер 17(7), С. 1257 - 1257

Опубликована: Апрель 3, 2025

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a public health concern, linked with immune-metabolic dysfunction. While lifestyle and dietary modifications remain the cornerstone of MASLD management, optimal approach remains uncertain. Objectives: This systematic review aims to investigate impact model patterns on metabolic outcomes in patients evaluate their effects individuals coexisting conditions, such as obesity, syndrome, type 2 diabetes mellitus (T2DM). Methods: To conduct review, PubMed, Scopus, Google Scholar, Cochrane CENTRAL, ClinicalTrials.gov databases were searched for Randomized Controlled Trials (RCTs) adult population, published between January 2019 September 2024, following PRISMA principles. The quality included RCTs was assessed qualitatively based study characteristics. Results: main findings this demonstrated that use interventions Mediterranean diet (MED) intermittent fasting (IF) approaches, alternative-day (ADF) time-restricted feeding regimens (TRF) may have potential reducing body weight, BMI, waist circumference, additional benefits improving glycemic control inflammation. hepatic functions, although limited, be reduced enzyme activity stiffness. Additionally, lacto-ovo-vegetarian (LOV-D) Dietary Approaches Stop Hypertension (DASH) offer benefits, including blood pressure management. Conclusions: suggests MED IF-based strategies reduce BW, improve control, lower inflammation, function. Further long-term studies are needed confirm these underlying mechanisms, which will allow optimization protocols ensure safety MASLD.

Язык: Английский

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Epicardial fat thickness is increased in menopausal patients in comparison with premenopausal patients with similar excess weight: a cross-sectional study

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Апрель 4, 2025

Язык: Английский

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Associations of healthy eating index 2020 and its components with non-alcoholic fatty liver disease in type 2 diabetes patients and the mediating roles of metabolic indicators: NHANES 2007–2018

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Апрель 9, 2025

Background Non-alcoholic fatty liver disease (NAFLD) represents a major public health issue, especially among individuals diagnosed with Type 2 diabetes mellitus (T2DM), where its prevalence can reach up to 70%. This research examines the relationship between Healthy Eating Index 2020 (HEI-2020) and individual components occurrence of NAFLD in T2DM patients, while also investigating potential mediating effects various metabolic indicators. Methods Data from National Health Nutrition Examination Survey (NHANES) spanning 2007 2018 were utilized. cross-section study included 1,770 who divided into non-NAFLD groups using Fatty Liver as diagnostic tool. The HEI-2020, which assesses diet quality, was computed based on 24-h dietary recall data. Key indicators such triglyceride-glucose (TyG) index, score (MS), mean arterial pressure, uric acid levels, total cholesterol evaluated. Results findings indicated that higher HEI-2020 scores associated lower likelihood (odds ratio 0.978, 95% confidence interval: 0.959–0.998), strongest inverse associations observed top quartiles quality. Whole fruits, greens beans, saturated fat crucial factors. Mediation analysis demonstrated TyG index MS accounted for 5.11 36.94% NAFLD, respectively. Conclusion Greater adherence is partially this association. Enhancing particularly by increasing consumption whole fruits reducing intake, may be important managing function vulnerable population.

Язык: Английский

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Advancing precision medicine in metabolic dysfunction-associated steatotic liver disease

Trends in Endocrinology and Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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Beyond Medication: Unveiling the Role of Diet and Lifestyle in Fatty Liver Disease Management

Human Nutrition & Metabolism, Год журнала: 2025, Номер unknown, С. 200317 - 200317

Опубликована: Апрель 1, 2025

Язык: Английский

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