Sleep habits in the pathogenesis and management of diabesity DOI Creative Commons
Cecilie Holm Rasmussen,

Chun Kwan O,

Wai Sze Chan

и другие.

Journal of Diabetes Investigation, Год журнала: 2025, Номер unknown

Опубликована: Июнь 1, 2025

ABSTRACT In parallel with the rising global epidemic of obesity and diabetes, termed “diabesity” to underscore strong relationship between these two conditions, there has been a decreasing trend in average sleep duration many parts world. Sleep is an essential component everyday life plays pivotal role regulating energy metabolism other physiological functions. Updated guidelines include adequate as one key elements lifestyle therapy diabetes management. From epidemiological studies, are researchers across globe demonstrating U‐shaped glycemia, well more adverse clinical outcomes (notably cardiovascular events mortality) shorter people diabetes. deprivation results inflammation, neurohormonal dysregulation impacting on appetite control, hedonic pathways, reward processing eventually facilitates While wealth evidence supporting mechanistic links short duration, weight gain, dysglycemia, reasons why long sleepers have worse metabolic health remain obscure. Not only matters, but circadian alignment quality also crucial optimizing health. Recognizing importance promoting hygiene via non‐pharmacological strategies, such extension interventions cognitive behavioral therapy, attracting increasing attention prevent manage diabesity.

Язык: Английский

Molecular Links Between Circadian Rhythm Disruption, Melatonin, and Neurodegenerative Diseases: An Updated Review DOI Creative Commons
K. Hüsnü Can Başer, Ismail Celil Haskologlu, Emine Erdag

и другие.

Molecules, Год журнала: 2025, Номер 30(9), С. 1888 - 1888

Опубликована: Апрель 23, 2025

Circadian rhythms are molecular oscillations governed by transcriptional–translational feedback loops (TTFLs) operating in nearly all cell types and fundamental to physiological homeostasis. Key circadian regulators, such as locomotor output cycles kaput (CLOCK), brain muscle ARNT-like 1 (BMAL1), period (PER), cryptochrome (CRY) gene families, regulate intracellular metabolism, oxidative balance, mitochondrial function, synaptic plasticity. disruption is known a central contributor the pathophysiology of neurodegenerative disorders. Disease-specific disruptions clock expression melatoninergic signaling potential early-stage biomarkers. Melatonin, neurohormone secreted pineal gland, modulates expression, stability, inflammatory responses. It also regulates epigenetic metabolic processes through nuclear receptors regulators involved cellular stress pathways, thereby exerting neuroprotective effects maintaining neuronal integrity. This review provides recent findings from past five years, highlighting how dysregulation mediates key disturbances translational circadian-based therapies diseases.

Язык: Английский

Процитировано

0
Chrononutrition: Potential, Challenges, and Application in Managing Obesity DOI Open Access

Siti Aisyah Fuad,

Rehna Paula Ginting, Min-Woo Lee

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(11), С. 5116 - 5116

Опубликована: Май 26, 2025

The circadian clock orchestrates nearly every aspect of physiology, aligning metabolic processes with environmental cues, such as light and food intake. While the central pacemaker in suprachiasmatic nucleus synchronizes peripheral clocks across key tissue, feeding behavior emerges dominant cue for alignment. This interaction reveals a crucial link between biology metabolism. Disruption these processes, whether from shift work, irregular eating patterns or lifestyle misalignment, has been strongly associated disorders, including obesity, insulin resistance cardiometabolic diseases. Within field chrononutrition, strategies, time-restricted (TRF), have gained attention their potential to restore alignment improve health. However, translational gaps persist, most mechanistic insights are derived nocturnal murine models, limiting applicability diurnal human physiology. Moreover, studies confounded by interindividual variability chronotype, behavioral patterns, dietary compliance. review explores molecular underpinnings zeitgeber signals critically assesses barriers implementing chrononutrition species. By integrating both preclinical clinical research, we aim refine circadian-based interventions disease prevention personalized nutrition.

Язык: Английский

Процитировано

0
Sleep habits in the pathogenesis and management of diabesity DOI Creative Commons
Cecilie Holm Rasmussen,

Chun Kwan O,

Wai Sze Chan

и другие.

Journal of Diabetes Investigation, Год журнала: 2025, Номер unknown

Опубликована: Июнь 1, 2025

ABSTRACT In parallel with the rising global epidemic of obesity and diabetes, termed “diabesity” to underscore strong relationship between these two conditions, there has been a decreasing trend in average sleep duration many parts world. Sleep is an essential component everyday life plays pivotal role regulating energy metabolism other physiological functions. Updated guidelines include adequate as one key elements lifestyle therapy diabetes management. From epidemiological studies, are researchers across globe demonstrating U‐shaped glycemia, well more adverse clinical outcomes (notably cardiovascular events mortality) shorter people diabetes. deprivation results inflammation, neurohormonal dysregulation impacting on appetite control, hedonic pathways, reward processing eventually facilitates While wealth evidence supporting mechanistic links short duration, weight gain, dysglycemia, reasons why long sleepers have worse metabolic health remain obscure. Not only matters, but circadian alignment quality also crucial optimizing health. Recognizing importance promoting hygiene via non‐pharmacological strategies, such extension interventions cognitive behavioral therapy, attracting increasing attention prevent manage diabesity.

Язык: Английский

Процитировано

0