Polymer Engineering and Science, Год журнала: 2024, Номер 64(10), С. 5229 - 5238

Опубликована: Авг. 8, 2024

Abstract Rheology plays a vital role in pneumatic three‐dimensional (3D) printing of hydrogels. This study investigates the rheological behavior novel self‐healing hydrogel (O‐MOG/CMCh) formed by Schiff base crosslinking reaction between oxidized Moringa oleifera gum (O‐MOG), biodegradable antimicrobial polysaccharide, and carboxymethyl chitosan (CMCh), water‐soluble biocompatible derivative. Three formulations were designed using 5% w/v CMCh with varied concentrations O‐MOG (3% w/v, 4% w/v) evaluated through rheology analyses, including frequency sweeps, amplitude oscillatory thixotropy, gelation kinetics. These tests revealed that material has shear thinning, properties, high linear viscoelastic region (LVE), gel formation times ( t ) 3.23–4.57 min. The synthesized composition exhibited best characteristics for printability based on assessments, this was used further assessment, where bi‐layered 4 × 2 grids successfully printed 22 G (0.41 mm) 23 (0.34 syringes. All constructs had index value 1 ± 0.13 spreading ratios <6.5, demonstrating feasibility employing as an acellular matrix via additive manufacturing. Highlights Self‐healing prepared mixing precursors cannula. examined standard assessment. 3D achieved two different gauze Printability parameters recorded analyzed constructs.

Язык: Английский