Late-stage functionalization of anticancer agent Daniquidone and the in vitro anticancer activities of the derivatives

European Journal of Medicinal Chemistry Reports, Год журнала: 2025, Номер unknown, С. 100269 - 100269

Опубликована: Апрель 1, 2025

Язык: Английский

Synthesis, Characterization, Molecular Docking, Cell viability and Biological Activity of New Metronidazole Analogues against Cellulitis Causing Pathogens

Asian Journal of Chemistry, Год журнала: 2025, Номер 37(5), С. 1224 - 1228

Опубликована: Апрель 30, 2025

Development of microbial resistance against commercial imidazoles intended present study to develop some new metronidazole analogues cellulitis causing pathogens. In study, N-(4-substituted benzylidene)-2-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethoxy)-acetohydrazide (2a-c) were synthesized by treating hydrazide derivative (1) with various aromatic aldehydes. The structures compounds 2a-c characterized using FT-IR, 1H NMR, 13C NMR and mass spectrometric data. evaluated for their inhibitory potential triggering bacteria S. aureus, E. coli cell viability profile MTT assay. Among 2a-c, compound 2c incorporated high electronegative group, exhibited maximum This was also supported the docking data glucosamine-6-phosphate (2VF5). significant antibacterial aureus coli, HEK 293 cells (more than 75%) score 2VF5 supports application in treatment. However, should be further vivo preclinical significance.

Язык: Английский

Repositioning Antivirals Against COVID-19: Synthetic Pathways, Mechanisms, and Therapeutic Insights

Microbial Pathogenesis, Год журнала: 2025, Номер unknown, С. 107724 - 107724

Опубликована: Май 1, 2025

Язык: Английский