Improving the Effectiveness of Anticancer Properties of Capecitabine using Aminocaproic Acid-Hyaluronic Acid/Sulfonamide IR-MOF Nanoplatform for Colon Cancer Treatment

Carbohydrate Polymer Technologies and Applications, Год журнала: 2025, Номер unknown, С. 100827 - 100827

Опубликована: Май 1, 2025

Язык: Английский

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Identification of oncogenes associated with colorectal cancer mortality and the effect of cinnamon-conjugated magnetic nanoparticles on their expression

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Май 20, 2025

Finding the molecular targets involved in severity and drug resistance of Colorectal cancer (CRC) applying targeted treatments against them is a promising approach. In this study, some candidate oncogenes related to disease mortality were identified by extracting bioinformatics data, effect Fe3O4@Glu-Cinnamon NPs on survival CRC cells (SW480) expression these was investigated. The characterized FT-IR, XRD, DLS zeta potential measurement, TEM SEM imaging, EDS-mapping VSM analysis. Cytotoxicity evaluated MTT assay flow cytometry analysis done investigate cell apoptosis/necrosis levels cycle cells. with spherical morphology correctly synthesized, containing no elemental impurities, size range 26.8-60.2 nm, 213 -15.4mV maximum magnetization level 20.33emu/g. Treatment elevated primary late apoptosis necrosis 20.85, 16.83 9.56% treated mainly arrested at S G2/M phases. associated mortality, SNAI1, THBS2 INHBA reduced 0.74, 0.66 0.7 folds, respectively. magnetic properties Fe3O4 enable their use delivery, allowing for site-specific accumulation within tumors. This could minimize systemic toxicity while enhancing treatment efficacy.

Язык: Английский

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Waste Biomass Utilization for the Production of Adsorbent and Value-Added Products for Investigation of the Resultant Adsorption and Methanol Electro-Oxidation

Catalysts, Год журнала: 2024, Номер 14(9), С. 574 - 574

Опубликована: Авг. 29, 2024

Waste valorization is necessary in today’s society to achieve a sustainable economy and prosperity. In this work, novel approach the waste of cuttlebone was investigated. This material ground calcined at 900 °C for 5 h an inert atmosphere. The resulting (CCB) characterized using XRD, SEM, FTIR, BET, TGA, Zetasizer, potential methods. main phases CCB were determined be CaO, MgO, Ca3(PO4)2, residual carbon. investigated as adsorbent removal dye from simulated wastewater streams. maximum adsorption capacities rhodamine B crystal violet dyes estimated 519 921 mg/g, respectively. For both dyes, Avrami model best-fit representing kinetics. study regeneration CV representative example involved use several chemical solvents. Ethanol solvent shown have highest method efficiency, reaching 65.20%. addition, methanol electro-oxidation energy generation. As concentration increased, current density produced by approximately 50 mA/cm2. work paves way toward natural matter production consumption material, per requirements circular principles.

Язык: Английский

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Fabricating modified carbon sesame straw for adsorption of acetaminophen and ibuprofen from aqueous media: isotherm and kinetic models

Environmental Science and Pollution Research, Год журнала: 2023, Номер 30(47), С. 104563 - 104576

Опубликована: Сен. 14, 2023

Язык: Английский

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Exploring metal carbamates as precursors for the synthesis of metal–organic frameworks

Dalton Transactions, Год журнала: 2024, Номер 53(30), С. 12582 - 12593

Опубликована: Янв. 1, 2024

The synthesis of HKUST-1 and UiO-66 from N , -diethylcarbamato complexes Cu( ii ) Zr( iv is explored, leading to protocols workable at ambient temperature.

Язык: Английский

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