Epitope-Based Vaccines: The Next Generation of Promising Vaccines Against Bacterial Infection
Vaccines,
Год журнала:
2025,
Номер
13(3), С. 248 - 248
Опубликована: Фев. 27, 2025
The
increasing
resistance
of
bacteria
to
antibiotics
has
underscored
the
need
for
new
drugs
or
vaccines
prevent
bacterial
infections.
Reducing
multidrug
is
a
key
objective
WHO’s
One
Health
initiative.
Epitopes,
parts
antigen
molecules
that
determine
their
specificity,
directly
stimulate
body
produce
specific
humoral
and/or
cellular
immune
responses.
Epitope-based
vaccines,
which
combine
dominant
epitopes
in
rational
manner,
induce
more
efficient
and
response
than
original
antigen.
While
these
face
significant
challenges,
such
as
epitope
escape
low
immunogenicity,
they
offer
advantages
including
minimal
adverse
reactions,
improved
efficacy,
optimized
protection.
As
result,
epitope-based
are
considered
promising
next-generation
approach
combating
This
review
summarizes
latest
advancements,
future
prospects
targeting
bacteria,
with
focus
on
development
workflow
application
antibiotic-resistant
pathogens
high
mortality
rates,
Staphylococcus
aureus,
Streptococcus
pneumoniae,
pyogenes,
Klebsiella
Acinetobacter
baumannii,
Pseudomonas
aeruginosa.
goal
this
provide
insights
into
vaccination
strategies
combat
infections
associated
antibiotic
rates.
Язык: Английский
Animal models of chronic obstructive pulmonary disease and their role in drug discovery and development: a critical review
Expert Opinion on Drug Discovery,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 12, 2025
Introduction
To
understand
the
mechanisms
of
COPD
and
to
discover
test
new
drugs,
laboratory
animals
are
essential.
However,
complex
changes
associated
with
disease
in
humans
difficult
fully
replicate
animal
models.
Язык: Английский
Organoids of Musculoskeletal System for Disease Modeling, Drug Screening, and Regeneration
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 28, 2024
Abstract
Musculoskeletal
diseases
have
emerged
as
the
leading
cause
of
disability
worldwide,
with
their
prevalence
increasing
annually.
In
light
this
escalating
health
challenge,
organoids,
an
emerging
technology
in
tissue
engineering,
offer
promising
solutions
for
disease
modeling,
drug
screening,
regeneration,
and
repair
processes.
The
successful
development
musculoskeletal
organoids
represents
a
significant
breakthrough,
providing
novel
platform
studying
facilitating
discovery
new
treatments.
Moreover,
serve
valuable
complements
to
traditional
2D
culture
methods
animal
models,
offering
rich
insights
into
biology.
This
review
provides
overview
organoid
technology,
outlining
construction
processes
various
highlighting
similarities
differences.
Furthermore,
challenges
associated
systems
are
discussed
future
perspectives
offered.
Язык: Английский
Natural ingredients in the regulation of abnormal lipid peroxidation: a potential therapy for pulmonary diseases
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 20, 2024
Pulmonary
diseases
are
a
major
category
of
that
pose
threat
to
human
health.
The
most
common
drugs
currently
used
treat
lung
still
chemical
drugs,
but
this
may
lead
drug
resistance
and
damage
healthy
organs
in
the
body.
Therefore,
developing
new
is
an
urgent
task.
Lipid
peroxidation
caused
by
disruption
redox
homeostasis,
accumulation
reactive
oxygen
species
(ROS),
depletion
glutathione
(GSH),
inactivation
peroxidase
4
(GPX4).
closely
related
occurrence
progression
respiratory
diseases,
including
acute
injury,
asthma,
pulmonary
fibrosis,
hypertension,
chronic
obstructive
disease,
cancer.
Natural
ingredients
have
high
safety,
availability,
low
cost,
can
regulate
lipid
through
multiple
pathways
targets,
making
them
valuable
drugs.
This
article
aims
summarize
pharmacology
mechanism
natural
targeting
treatment
diseases.
reviewed
data
indicate
promising
anti-lipid
drug,
mainly
alleviating
cystine/glutamate
antiporter
(System
X
Язык: Английский