Infectious Diseases,
Год журнала:
2023,
Номер
55(7), С. 490 - 508
Опубликована: Май 18, 2023
Background
In
2022,
there
were
outbreaks
of
Mpox
where
the
disease
is
not
endemic.
We
summarised
and
compared
findings
from
published
observational
studies
on
clinical
presentation
epidemiology
2022
previous
Mpox.Methods
registered
a
review
protocol
with
Open
Science
Framework
(osf.io/j3kb7).
searched
MEDLINE,
Embase,
CENTRAL,
CINAHL
Scopus
databases,
relevant
websites
up
to
August
30,
2022.
Retrieved
literature
citations
screened
for
eligibility,
summary
epidemiological
data
included
pooled,
when
possible,
using
an
inverse
variance,
random-effects
model.Results
Seventy-nine
met
eligibility.
Irrespective
outbreak,
fever,
headache,
myalgia,
lymphadenopathy,
pleomorphic
skin
lesions,
oral
sore
throat
potentially
highly
manifestations,
while
conjunctivitis,
cough,
possibly
reactivation
varicella
zoster
virus
may
be
part
presentation.
The
mean
incubation
period
was
7.4
d
(6.4–8.4
d,
I2
64.2%;
4
studies:
270
cases)
outbreaks,
12.9
(10.4–15.5
d;
one
study:
31
cases),
p
<
.001.
None
male
cases
reported
have
sex
men
(MSM)
whereas
almost
all
outbreak
MSM.
Concomitant
sexually
transmitted
infections
perianal
lesions
only
among
mostly
presenting
genital
lesions.Conclusions
appear
MSM
lower
outbreaks.Key
messages79
review's
inclusion
criteria.The
shorter
outbreaks.Established
includes
throat.Almost
who
had
(MSM).Concomitant
outbreaks.A
significantly
higher
proportion
outbreaks.The
Vaccines,
Год журнала:
2023,
Номер
11(2), С. 246 - 246
Опубликована: Янв. 22, 2023
The
most
recent
monkeypox
(Mpox)
outbreak
is
mostly
affecting
men
who
have
sex
with
(MSM)
participate
in
high-risk
sexual
behaviors,
which
typically
the
case
among
human
immunodeficiency
virus
(HIV)
carriers,
according
to
clinical
and
epidemiological
statistics.
objective
of
this
research
determine
situation
HIV
smallpox
co-infection.
Until
1
October
2022,
a
thorough
evaluation
literature
was
conducted
utilizing
databases
PubMed,
Embase,
Scopus,
Web
Science.
Studies
were
evaluated
based
on
criteria
for
selection.
Fifty-three
studies
met
selection
criteria.
A
total
6345
confirmed
cases
recorded,
40.32%
(n
=
2558)
these
also
had
In
addition,
51.36%
3259)
(91.44%;
n
5802),
whose
ages
ranged
from
18
71
years,
exhibited
MSM-specific
behaviors.
Co-infection
two
viruses
can
be
especially
dangerous
because
it
exacerbate
symptoms
both
diseases
make
them
more
difficult
treat.
People
are
vulnerable
certain
infections,
including
monkeypox,
their
immune
systems
weakened.
Therefore,
important
that
they
take
measures
prevent
infection,
such
as
avoiding
contact
infected
animals,
risky
maintaining
good
hygiene.
Emerging Microbes & Infections,
Год журнала:
2022,
Номер
11(1), С. 2600 - 2631
Опубликована: Окт. 20, 2022
The
current
outbreak
of
monkeypox
(MPX)
infection
has
emerged
as
a
global
matter
concern
in
the
last
few
months.
MPX
is
zoonosis
caused
by
virus
(MPXV),
which
one
Orthopoxvirus
species.
Thus,
it
similar
to
smallpox
variola
virus,
and
vaccines
drugs
have
been
shown
be
protective
against
MPX.
Although
not
new
disease
rarely
fatal,
multi-country
unusual
because
occurring
countries
that
are
endemic
for
MPXV.
In
this
work,
we
reviewed
extensive
literature
available
on
MPXV
summarize
data
major
biological,
clinical
epidemiological
aspects
important
scientific
findings.
This
review
may
helpful
raising
awareness
transmission,
symptoms
signs,
prevention
measures.
It
also
interest
basis
performance
studies
further
understand
MPXV,
with
goal
combating
boosting
healthcare
services
hygiene
practices.Trial
registration:
ClinicalTrials.gov
identifier:
NCT02977715..Trial
NCT03745131..Trial
NCT00728689..Trial
NCT02080767..
Pathogens,
Год журнала:
2023,
Номер
12(7), С. 947 - 947
Опубликована: Июль 18, 2023
Monkeypox
virus
(MPXV)
is
an
emerging
zoonotic
that
belongs
to
the
Orthopoxvirus
genus
and
presents
clinical
symptoms
similar
those
of
smallpox,
such
as
fever
vesicular-pustular
skin
lesions.
However,
differential
diagnosis
between
smallpox
monkeypox
does
not
cause
lymphadenopathy
but
generates
swelling
in
lymph
nodes.
Since
eradication
MPXV
has
been
identified
most
common
human
disease.
Despite
being
endemic
certain
regions
Africa,
current
outbreak,
which
began
early
2022,
spread
numerous
countries
worldwide,
raising
global
concern.
As
end
May
2023,
over
87,545
cases
141
deaths
have
reported,
with
non-endemic
countries,
primarily
due
human-to-human
transmission.
To
better
understand
this
threat,
review
overview
key
aspects
infection,
including
its
animal
reservoirs,
modes
transmission,
models,
epidemiology,
immunological
features,
diagnosis,
treatments,
vaccines,
prevention
strategies.
The
material
presented
here
provides
a
comprehensive
understanding
disease,
while
emphasizing
significance
unique
characteristics
2022
outbreak.
This
offers
valuable
information
can
inform
future
research
aid
development
effective
interventions.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Июнь 26, 2023
Since
May
2022,
mutant
strains
of
mpox
(formerly
monkeypox)
virus
(MPXV)
have
been
rapidly
spreading
among
individuals
who
not
traveled
to
endemic
areas
in
multiple
locations,
including
Europe
and
the
United
States.
Both
intracellular
extracellular
forms
outer
membrane
proteins
that
can
stimulate
immune
response.
Here,
we
investigated
immunogenicity
MPXV
structural
such
as
A29L,
M1R,
A35R,
B6R
a
combination
vaccine,
protective
effect
against
2022
strain
was
also
evaluated
BALB/c
mice.
After
mixed
15
μg
QS-21
adjuvant,
all
four
were
administered
subcutaneously
Antibody
titers
mouse
sera
rose
sharply
after
initial
boost,
along
with
an
increased
capacity
cells
produce
IFN-γ
alongside
elevated
level
cellular
immunity
mediated
by
Th1
cells.
The
vaccine-induced
neutralizing
antibodies
significantly
inhibited
replication
mice
reduced
pathological
damage
organs.
This
study
demonstrates
feasibility
recombinant
vaccine
for
variant
strains.
Microorganisms,
Год журнала:
2023,
Номер
11(5), С. 1186 - 1186
Опубликована: Апрель 30, 2023
Mpox—formerly
monkeypox—is
a
re-emerging
zoonotic
virus
disease,
with
large
numbers
of
human
cases
reported
during
multi-country
outbreaks
in
2022.
The
close
similarities
clinical
symptoms
that
Mpox
shares
many
orthopoxvirus
(OPXV)
diseases
make
its
diagnosis
challenging,
requiring
laboratory
testing
for
confirmation.
This
review
focuses
on
the
diagnostic
methods
used
detection
naturally
infected
humans
and
animal
reservoirs,
disease
prevalence
transmission,
signs,
currently
known
host
ranges.
Using
specific
search
terms,
up
to
2
September
2022,
we
identified
104
relevant
original
research
articles
case
reports
from
NCBI-PubMed
Google
Scholar
databases
inclusion
study.
Our
analyses
observed
molecular
identification
techniques
are
overwhelmingly
being
current
diagnoses,
especially
real-time
PCR
(3982/7059
cases;
n
=
41
studies)
conventional
(430/1830
30
approaches
most-frequently-used
diagnose
humans.
Additionally,
genomes,
using
qPCR
and/or
coupled
genome
sequencing
methods,
offered
both
reliable
epidemiological
evolving
strains;
emergence
transmission
novel
clade
‘hMPXV-1A’
lineage
B.1
2022
globally.
While
few
serologic
assays,
such
as
ELISA,
OPXV-
Mpox-specific
IgG
(891/2801
17
IgM
antibodies
(241/2688
11
studies),
hemagglutination
inhibition
(HI)
detected
samples
(88/430
6
most
other
immunographic
assays
were
OPXV-specific.
Interestingly,
isolation
(228/1259
24
electron
microscopy
(216/1226
18
immunohistochemistry
(28/40;
7
remain
useful
select
instances
tissue
samples.
In
animals,
Mpox-DNA
various
species
nonhuman
primates,
rodents,
shrews,
opossums,
dog,
pig.
With
dynamics
Mpox,
information
rapid
is
critical
management.
