Respiratory virus detections in children presenting to an Australian paediatric referral hospital pre-COVID-19 pandemic, January 2014 to December 2019

PLoS ONE, Год журнала: 2025, Номер 20(1), С. e0313504 - e0313504

Опубликована: Янв. 22, 2025

Acute respiratory infections cause significant paediatric morbidity, but for pathogens other than influenza, syncytial virus (RSV), and SARS-CoV-2, systematic monitoring is not commonly performed. This retrospective analysis of six years routinely collected pathogen multiplex PCR testing at a major hospital in New South Wales Australia, describes the epidemiology, year-round seasonality, co-detection patterns 15 viral pathogens. 32,599 samples from children aged under 16 were analysed. Most associated with admission (24,149, 74.1%) median age sampling was months (IQR 5–53). Viruses detected 62.9% (20,510) samples, single detections occurring 73.5% (15,082) positive samples. In instances detection, rhinovirus most frequent (5125, 40.6%), followed by RSV-B (1394, 9.2%) RSV-A (1290, 8.6%). Moderate to strong seasonal strength observed viruses some notable exceptions. Rhinovirus enterovirus low adenovirus bocavirus. Biennial influenza B parainfluenza 2. Co-detections occurred 5,428 predominantly two (4284, 79.0%) or three (904, 16.7%). The common co-detections rhinovirus-adenovirus (566, 10.4%), rhinovirus-enterovirus (357, 8.3%), rhinovirus-RSV-B (337, 7.9%). Ongoing pan-pathogen surveillance, integrating both laboratory clinical data, necessary assist identification key combination support effective preventative public health strategies reduce burden infections.

Язык: Английский

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Changes in Respiratory Viruses’ Activity in Children During the COVID-19 Pandemic: A Systematic Review

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(4), С. 1387 - 1387

Опубликована: Фев. 19, 2025

Background/Objectives: The impact of the coronavirus disease 2019 (COVID-19) pandemic on health was significant worldwide. measures adopted to limit spread virus had an indirect effect epidemiology other infectious diseases with similar mechanisms inter-human transmission. present literature review analyzed scenario pediatric acute respiratory infections in post-lockdown period compared pre-pandemic and lockdown periods. different patterns viruses' outbreaks were evaluated according type local COVID-19 restrictive pathogen. Methods: Relevant scientific published between March 2020 November 2024 identified by means electronic keyword searches PubMed, Scopus, Cochrane Library databases. Results: Worldwide implementation non-pharmacological public interventions aimed at limiting resulted a measurable circulation common viruses, significantly affecting their usual seasonality. Most viruses reduced activity during but returned or exceeded historical levels after discontinuation preventive measures. For many particularly syncytial virus, off-season increase reported. Conclusions: interventions, which effectively helped pandemic, relevant epidemiologic changes most viruses. Given seasonality clinical severity observed for some pathogens lockdown, possible future more severe epidemics should be expected.

Язык: Английский

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Mycoplasma pneumoniae infection outbreak in Guangzhou, China after COVID-19 pandemic

Virology Journal, Год журнала: 2024, Номер 21(1)

Опубликована: Авг. 11, 2024

Mycoplasma pneumoniae (M. pneumoniae) is a common pathogen causing respiratory diseases in children. This study aimed to characterize epidemiological and disease severity shifts of M. pneumoniae: infections Guangzhou, China during after the coronavirus 2019 (COVID-19) pandemic. Throat swab samples were obtained from 5405 hospitalized patients with symptoms acute detect pneumoniae. Differences clinical characteristics investigated 2020–2022 COVID-19 pandemic (2023). detected 849 (15.6%, 849/5405) patients. The highest annual positive rate was 29.4% (754/2570) 2023, followed by 5.3% (72/1367) 2022, 1.2% (12/1015) 2021, 2.0% (11/553) 2020, significantly increasing prevalence 2020 2023. incidence peaked between July December post-COVID-19 monthly (56.4%, 165/293). Clinical outcomes did not vary periods except that more likely develop fever. Patients severe pneumonia (SMPP) complications, myocardial damage, gastrointestinal dysfunction than those non-SMPP. SMPP had lower lymphocytes, CD3+ T cells, CD4+ CD8+ B higher IL-4, IL-6, IL-10 levels Bronchoalveolar lavage fluid specimens infected identify macrolide resistance mutations. Macrolide-resistant (MRMP) proportion 2023 91.1% (215/236). Outbreaks occurred upon Non-pharmaceutical interventions easing. Despite pneumoniae, remained similar

Язык: Английский

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Changes in infant respiratory pathogens pre-, during, and post-COVID-19 non-pharmacological interventions in Beijing

˜The œItalian Journal of Pediatrics/Italian journal of pediatrics, Год журнала: 2025, Номер 51(1)

Опубликована: Янв. 22, 2025

Abstract Background To explore the effect of non-pharmacological interventions (NPIs) on respiratory pathogen profiles among hospitalized infants aged 0–3 months in Beijing during coronavirus disease 2019 (COVID-19) pandemic. Methods Respiratory specimens were collected from 1,184 who for acute infection at Children’s Hospital affiliated with Capital Institute Pediatrics January 2018 to December 2023. The data divided into three groups—the pre-epidemic (January 2019), epidemic prevention and control 2020 2022), post-epidemic 2023 2023) groups—based outbreak COVID-19 implementation termination NPIs. tested 14 pathogens, including influenza virus A (Flu A), B, syncytial virus, parainfluenza (PIV), adenovirus (ADV), human metapneumovirus (HMPV), bocavirus, rhinovirus (HRV), coronavirus, Chlamydia trachomatis , pneumoniae (C.pn), Mycoplasma Bordetella pertussis severe syndrome 2 (SARS-CoV-2). Results total infants, 649 males 535 females, infections admitted. positive detection rate pathogens was 51.77% ( n = 613). In 2023, proportion after 19.4% (319/1646), 68.3% (218/319), mixed 16.1% (35/218). Prior epidemic, these rates 11.9% (431/3611), 37.1% (160/431), 5.0% (8/160), respectively. During period, significantly increased 12.4% (434/3486), 54.1% (235/434), 11.1% (26/235) P < 0.05), Post-epidemic, newborns testing decreased, while number 29–90 days increased. admission weight contact history patients compared before statistical significance 0.05). After a 13 detected throughout year. There statistically significant differences Flu A, PIV, SARS-CoV-2, HRV, HMPV, ADV, C.pn before, during, NPIs SARS-CoV-2 higher than those 0.017). ADV Before positivity high first fourth quarters. NPIs, decreased quarter but second, third, quarters, difference Conclusion lifting have caused changes seasonal distribution Beijing. temporarily reduced prevalence COVID-19. Understanding is particularly important diseases infants.

Язык: Английский

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Presence and Significance of Multiple Respiratory Viral Infections in Children Admitted to a Tertiary Pediatric Hospital in Italy

Viruses, Год журнала: 2024, Номер 16(5), С. 750 - 750

Опубликована: Май 9, 2024

Viral co-infections are frequently observed among children, but whether specific viral interactions enhance or diminish the severity of respiratory disease is still controversial. This study aimed to investigate type mono- and by also evaluating correlations in 3525 samples from pediatric in/outpatients screened Allplex Respiratory Panel Assays with a Severe Acute Syndrome-COronaVirus 2 (SARS-CoV-2) test available. Overall, were detected 37.8% patients more specimens children lower tract infections compared those upper (47.1% vs. 36.0%, p = 0.003). SARS-CoV-2 influenza A commonly mono-infections, whereas human bocavirus showed highest co-infection rate (87.8% co-infection). After analyzing pairings using Spearman’s correlation test, it was noted that negatively associated all other viruses, markedly significant positive (p < 0.001) for five (involving adenovirus/human bocavirus/human enterovirus/metapneumoviruses/rhinovirus). The between clinical outcome may be linked virus(es) involved rather than simple co-presence. Further studies dedicated this important point needed, since has obvious implications diagnostic view.

Язык: Английский

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Tenfold Increase: Acute Pediatric Mastoiditis Before, During, and After COVID-19 Restrictions

Otology & Neurotology, Год журнала: 2024, Номер 45(7), С. 777 - 782

Опубликована: Июль 2, 2024

Acute mastoiditis (AM) is a relatively rare complication arising from acute otitis media, common condition among children. The COVID-19 pandemic has significantly impacted AM cases. We noted surge in pediatric cases Germany after restrictions were lifted 2022. This study assesses incidence and the clinical course children before, during, pandemic. also explores rates microbial changes.

Язык: Английский

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Circulation and Codetections of Influenza Virus, SARS-CoV-2, Respiratory Syncytial Virus, Rhinovirus, Adenovirus, Bocavirus, and Other Respiratory Viruses During 2022–2023 Season in Latvia

Viruses, Год журнала: 2024, Номер 16(11), С. 1650 - 1650

Опубликована: Окт. 22, 2024

This retrospective study analysed the routine data obtained by multiplex real-time RT-qPCR methods for respiratory virus detection. A total of 4814 specimens collected during 1 September 2022-31 August 2023 were included in study. 38% positive at least one target, with incidence maximum (82%) small children (age group 0-4 years). The five dominant groups rhinovirus (RV, 12%), influenza (IAV, 7%), adenovirus (AdV, 6%), syncytial (RSV, 5%), and severe acute syndrome coronavirus 2 (SARS-CoV-2, 5%). multi-detections represented 19% positives, unevenly distributed (n = 225, 56, 43, 24) among age 0-4, 5-14, 15-64, 65< years, respectively. multi-positive RV (53%), AdV (43%), bocavirus (BoV, 35%)-in mutual pairs as well all three together-followed RSV (21%), IAV (15%). Our focused on codetections provides an insight into variety interactions Latvia first year since pandemic-related social restriction measures eased. observations also emphasise need to consider differentiation between rhinoviruses enteroviruses, especially youngest patients 0-4.

Язык: Английский

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Epidemiological changes of acute respiratory infections in children: A single-center experience after COVID-19 lockdown

PLoS ONE, Год журнала: 2024, Номер 19(4), С. e0300877 - e0300877

Опубликована: Апрель 5, 2024

Background Since the start of COVID-19 pandemic, epidemiology acute respiratory infections (ARIs) has continually changed, making it difficult to predict. Our study aimed evaluate epidemiological changes and clinical outcomes ARIs in pediatric patients post-lockdown period. Methods A single-center retrospective cross-sectional was performed one largest emergency departments Lithuania during two cold seasons–from October 1, 2021, April 30, 2022 (Season I) same period 2022–2023 II). Patients under 18 years age who had been tested for were enrolled study. Additional data about other pathogens group (specifically influenza A/B, syncytial virus (RSV) Streptococcus (GAS)), included. Results During both seasons our study, 19,366 children screened COVID-19. Positive tests decreased from 14.5% Season I 5.9% II, while at time, rates increased significantly: 17.5% 27.1%, RSV 8.8% 27.6%, GAS 8.4% 44%, respectively. In infection presented fewer admissions intensive care (0.8% vs. 3.7%, p<0.01) there no deaths, a higher proportion hospitalizations (10.5% 6.1%, death. The also II (34.6% 44.0%, p<0.01). Conclusions early saw decline re-emergence influenza, children. cases became milder contrary influenza. contributed significantly seasons, particularly II. Coinfections not associated with more severe course disease.

Язык: Английский

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Post-Pandemic Epidemiology of Respiratory Infections among Pediatric Inpatients in a Tertiary Hospital in Shanghai, China

Children, Год журнала: 2024, Номер 11(9), С. 1127 - 1127

Опубликована: Сен. 17, 2024

Background: After the removal of three-year epidemic control restrictions, Chinese children were confronted with heightened risks respiratory infections. We aimed to investigate post-pandemic (2023) epidemiology infections among pediatric inpatients in a tertiary hospital Shanghai, China, and compare it pre-pandemic (2019) levels. Methods: A total 2644 enrolled based on discharge time divided into group 2019 (n = 1442) 2023 1202). Information demographic characteristics, diagnoses, pathogen test results (Mycoplasma pneumoniae, MP; Chlamydia CP; Legionella pneumophila, LP; Influenza A, IFA; B, IFB; Parainfluenza virus, PIV; syncytial RSV; Coxsackie COX; Adenovirus, ADV; Epstein–Barr EBV) was collected analyzed. Results: Significant increases found overall positivity rates (64.6% vs. 46.7%), mixed infection (17.4% 9%), proportion severe cases (25.5% 3.7%) after pandemic than those before it. Compared 2019, incidences MP, IFA, LP, RSV, ADV remarkably increased, while IFB COX decreased, no obvious differences noted for CP, PIV, EBV 2023. significantly higher MP-positive detection rate noticed aged 1–6 years 2019. The incidence RSV began rise August 2023, earlier conventional season. Conclusions: levels, atypical pathogens viruses alterations disease spectrum, season, age prevalence observed COVID-19 pandemic.

Язык: Английский

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Responding to daily volume surges in real time in an academic setting: the “Ad Hoc” shift

Current Problems in Diagnostic Radiology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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