People Living With HIV have a prolonged virus shedding duration even with anti-SARS-CoV-2 treatment：a retrospective cohort study in Wuhan, China
Abstract
Objective
This
study
aimed
to
investigate
the
clearance
of
SARS-CoV-2
in
people
living
with
HIV
(PLWH)
after
receiving
anti-SARS-CoV-2
treatment
and
relevant
factors.
Methods
A
retrospective
investigation
was
conducted
based
on
clinical
data
patients
between
December
2022
June
2023.
The
were
categorized
into
PLWH
HIV-negative
groups.
Basic
information,
comorbidity,
COVID-19
severity,
white
blood
cell
count,
lymphocyte
medicine,
steroid
usage,
virus
shedding
duration
collected.
Kaplan-Meier
curve
employed
compare
rates,
multivariate
logistic
regression
Cox
analyses
utilized
identify
factors
influencing
duration.
Results
total
149
(32
117
individuals)
enrolled
study.
median
estimated
for
group
are
21
days
14
days,
respectively
(P
<
0.001).
rates
at
5th
day
15.63%
60.68%
0.001),
28th
87.50%
97.44%
=
0.019)
groups,
respectively.
Multivariate
analysis
showed
that
infection
(OR
0.026,
95%
CI:
0.004–0.159)
count
admission
4.341,
1.536–12.265)
independent
0.05).
Compared
mild
group,
moderate
severe
groups
had
significant
impacts
both
revealed
age
0.977,
0.963–0.991),
0.351,
0.197–0.626),
therapy
initiation
0.827,
0.786–0.871),
1.999,
1.372–2.914)
moderate,
severe,
critically
ill
statistically
nucleic
acid
conversion
Conclusion
a
prolonged
even
treatment,
which
could
lead
more
opportunities
accumulate
multiple
mutations
induce
resistance
medicines.
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Окт. 17, 2024
Язык: Английский
