Measuring Post-Exertional Malaise with DePaul Symptom Questionnaires: Challenges and Opportunities
OBM Neurobiology,
Год журнала:
2025,
Номер
09(01), С. 1 - 30
Опубликована: Фев. 5, 2025
Following
mental
or
physical
exertion,
patients
with
Myalgic
Encephalomyelitis/Chronic
Fatigue
Syndrome
(ME/CFS)
experience
Post-Exertional
Malaise
(PEM).
Although
self-report
questions
represent
less
expensive
and
invasive
procedures
to
assess
PEM,
variability
in
the
wording
of
symptom
can
cause
reliability
validity
problems.
If
different
PEM
measures
are
used
studies,
this
could
create
difficulties
replicating
findings,
identifying
biomarkers,
determining
effective
treatments
for
patients.
The
objective
article
is
describe
challenges
opportunities
DePaul
Symptom
Questionnaires
(DSQ)
specific.
five
DSQ
items
identify
97%
ME/CFS.
A
brief
DSQ-PEM
instrument
has
now
been
constructed
that
consists
supplementary
such
as
duration
how
quickly
would
recover
from
activities.
more
comprehensive
called
Questionnaire
assesses
a
list
triggers
length
recovery
time
PEM.
In
article,
we
show
DSQ’s
provide
clues
ME/CFS
pathophysiology
well
these
be
outcome
measures.
Future
research
should
focus
on
contrasting
comparing
ways
eliciting
assessing
relationships
between
questionnaires
examining
impact
treatment
trials
Язык: Английский
Cardiac structure and function 1.5 years after COVID-19: results from the EPILOC study
Infection,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 24, 2025
Impaired
left
and
right
ventricular
(LV/RV)
function
during
acute
SARS-CoV-2
infection
has
been
predominantly
reported
in
hospitalized
patients,
but
long-term
cardiac
sequelae
large,
well-characterized
cohorts
remain
inconclusive.
This
study
evaluated
structure
individuals
with
post-Coronavirus
disease
(COVID)
syndrome
(PCS)
compared
to
recovered
controls
(CON),
focusing
on
associations
cardiopulmonary
symptoms
rapid
physical
exhaustion
(RPE).
multicenter,
population-based
included
1154
participants
(679
PCS,
475
age-
sex
matched
CON;
mean
age
49
±
12
years;
760
women)
1.5
years
post-infection.
Transthoracic
echocardiography
assessed
LV
global
longitudinal
strain
(GLS),
RV
GLS
free
wall
(FWS),
other
measures.
Cardiopulmonary
exercise
testing
(CPET)
measured
maximum
respiratory
oxygen
uptake
(VO2max)
as
a
marker
of
fitness.
PCS
exhibited
significantly
lower
(-20.25%
[-21.28
-
-19.22]
vs.
-20.73%
[-21.74
-19.72],
p
=
0.003),
reduced
diastolic
(E/A
1.16
[1.04-1.27]
1.21
[1.1-1.32],
0.022)
decreased
TAPSE
(24.45
mm
[22.14-26.77]
25.05
[22.78-27.32],
CON,
even
after
adjusting
for
confounders.
values
were
similar
between
groups.
correlated
inversely
VO2max
(p
0.004)
positively
RPE
0.050),
though
no
observed
symptoms.
demonstrates
subtle
yet
consistent
reductions
function,
specifically
capacity
CON.
While
these
changes
are
within
reference
ranges,
their
potential
impact
clinical
outcomes
warrants
further
investigation.
These
findings
highlight
the
need
assessments
follow-up
symptomatic
patients.
Язык: Английский
Multimodal Telerehabilitation in Post COVID-19 Condition Recovery: A Series of 12 Cases
Reports — Medical Cases Images and Videos,
Год журнала:
2025,
Номер
8(1), С. 35 - 35
Опубликована: Март 20, 2025
Background:
Post
COVID-19
Condition
is
a
recently
recognized
syndrome
characterized
by
the
persistence
of
various
symptoms,
including
dyspnea,
physical
and
mental
fatigue,
post-exertional
malaise.
Currently,
there
no
established
treatment
or
clear
consensus
on
effectiveness
rehabilitation,
given
that
patients
could
benefit
from
home-based
telerehabilitation,
defined
as
remote
rehabilitation
using
telematic
systems,
may
be
an
option
to
reach
more
population
with
persistent
symptoms.
Therefore,
it
necessary
show
efficacy
this
approach
benefits
multimodal
strategy
in
these
patients.
Methods:
Patients
underwent
home
12-week
synchronous
telerehabilitation
system.
The
intervention
included
therapeutic
education
respiratory
rehabilitation.
following
variables
were
analyzed:
Fatigue,
quality
life,
strength,
aerobic
capacity,
upper
lower
limb
strength.
Conclusions:
After
12
weeks,
significant
improvements
found
However,
improvement
was
dyspnea
scores,
which
did
not
correlate
Interestingly,
post-intervention
correlation
emerged
between
distance
covered
capacity
perceived
suggesting
asynchronous
viable
for
Язык: Английский
Patient Perspectives on the Care in a Long COVID Outpatient Clinic—A Regional Qualitative Analysis from Germany
Healthcare,
Год журнала:
2025,
Номер
13(7), С. 818 - 818
Опубликована: Апрель 3, 2025
Background/Objectives:
Long
COVID
specialized
outpatient
clinics
(sOCs),
which
are
part
of
the
recommended
long
care,
usually
face
high
demand.
Few
studies
focused
on
experience
care
in
such
facilities
Germany.
This
study
investigated
how
patients
a
sOC
at
German
university
hospital.
Methods:
Semi-structured
interviews
were
conducted
with
attending
this
clinic
between
October
2022
and
January
2023.
Data
analysis
was
based
thematic
analysis.
Results:
The
themes
from
14
(F
=
11,
M
3)
could
be
broadly
categorized
into
statements
pathway
to
sOC,
provided
sOC.
Findings
show
that
patients'
expectations
appointment
shaped
by
previous
experiences
mainly
perceived
as
inadequate.
Care
predominantly
competent,
empathetic
relevant
for
further
coping
disease.
A
deterioration
health
directly
related
consultation
(classifiable
post-exertional
malaise)
frequently
described,
need
ongoing
consultation.
Conclusions:
Overall,
findings
point
adaptations
identifying
optimized
models
tailoring
them
limited
resources.
includes
measures
improve
outside
Язык: Английский
Possible link between steatotic liver diseases, severe COVID-19 and cognitive impairment in post-COVID-19 syndrome
Infection,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 10, 2025
Abstract
Purpose
Steatotic
liver
diseases
(SLD)
have
become
more
prevalent
over
the
last
decade
and
are
associated
not
only
with
cardiometabolic
but
also
psychological
symptoms
(depression,
fatigue).
These
common
in
post-COVID
syndrome
(PCS).
Therefore,
aim
of
study
was
to
analyze
burden
SLD
PCS
patients.
Methods
We
systematically
screened
all
patients
from
our
outpatient
clinic
using
transient
elastography,
structured
questionnaires
for
neurocognitive
evaluation
blood
sample
analysis.
Controls
without
known
were
recruited
assessed
same
approach.
Results
560
103
healthy
controls
included.
The
overall
prevalence
high
both
cohorts
(57
vs.
53%).
frequently
male
(41
24%),
older
(52
44
years)
had
(87.0
46.4%).
Cognitive
impairment
related
than
no-SLD
group
(OR:
1.68,
CI:
1.14–2.46,
p
=
0.008).
presence
severe
COVID-19
hospitalization
2.91,
1.85–4.56,
<
0.001).
Within
1
year
follow-up,
152
289
described
a
resolution
irrespective
or
absence
(log-rank
0.96).
Conclusions
is
cognitive
dysfunction
PCS.
Longitudinal
studies
needed
assess
role
hepatic
steatosis,
development
post-acute
infection
regulation
(e.g.,
SARS-CoV-2)
differentiate
between
SLD-associated
Язык: Английский