Immunohistochemical‐Based Molecular Typing of ACRG Combined With Immune‐Associated PD‐L1 Expression Can Predict the Prognosis of Gastric Cancer DOI Creative Commons

Fang Li,

Huiyan Deng, Zeqing Hu

и другие.

Cancer Medicine, Год журнала: 2025, Номер 14(7)

Опубликована: Апрель 1, 2025

ABSTRACT Background Gastric cancer (GC) is a molecularly heterogeneous disease with diverse clinical outcomes. Traditional classifications lack predictive accuracy, necessitating alternative molecular subtyping approaches for effective prognosis prediction. The Asian Cancer Research Group (ACRG) subtypes, combined immune‐associated PD‐L1 expression, offer promising framework to predict patient outcomes and potentially guide treatment strategies in GC. Methods This study retrospectively analyzed 1007 primary GC patients who underwent surgical resection between January 2017 June 2019 at the Fourth Hospital of Hebei Medical University. Comprehensive immunohistochemical fluorescent PCR‐capillary electrophoresis analyses were conducted determine ACRG subtypes (microsatellite instability [MSI], microsatellite stability epithelial–mesenchymal transition [MSS/EMT], MSS/TP53 + , − ) expression. We assessed relationship these various clinicopathological parameters, including survival outcomes, using Cox regression Kaplan–Meier analysis. Results showed significant associations features, tumor invasion depth, Lauren classification, HER2 status. MSI subtype (6.7% cases) was associated higher positivity favorable prognosis, whereas EMT had lowest 5‐year rate (34.55%) predominantly linked diffuse‐type histology. correlated worse independent value alongside (HR = 1.759, p 0.001; HR 5.144, < 0.001). Conclusion combination expression serves as an predictor facilitating tailored decision‐making. ACRG‐PD‐L1 classification system offers practical, cost‐effective approach routine application, providing critical insight into heterogeneity. Further multicenter studies are needed validate findings explore impact on therapy responses, particularly immunotherapy settings.

Язык: Английский

The protective effects of cheese intake on joint pain and underlying biomarkers: Insights from the Mendelian randomization DOI Creative Commons
Kaiqin Chen, Jianwu Wu, Yaolin Xu

и другие.

Journal of Dairy Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

This study aimed to investigate the relationship between cheese consumption and risk of joint pain, as well assess mediating role biomarkers. Utilizing Mendelian randomization methods, we analyzed data from UK Biobank FinnGen evaluate link intake examining 44 biomarkers potential mediators. The findings revealed a significant inverse association mediated by various biomarkers, including neutrophil count, apolipoprotein A, peak expiratory flow, cystatin C, IGF-1, sex hormone–binding globulin, urate, automated diastolic blood pressure. These results suggest that may reduce pain affecting specific providing scientific basis for dietary interventions decrease incidence pain. However, study's limitations include ethnic homogeneity sample population incomplete analysis indicating need further research confirm expand upon these initial findings.

Язык: Английский

Процитировано

0
Vitamin D supplementation for managing COVID-19 in patients with vitamin D deficiency: a systematic review and meta-analysis of randomised controlled trials DOI Creative Commons
Lemei Zhu, Yuan Zhang, Xi Li

и другие.

BMJ Open, Год журнала: 2025, Номер 15(3), С. e091903 - e091903

Опубликована: Март 1, 2025

Objectives Vitamin D deficiency is prevalent among the population. Previous studies have shown that vitamin supplementation might be useful for treating COVID-19 infection. Therefore, we performed a meta-analysis to explore efficacy in patients with deficiency. Design Systematic review and Data sources PubMed, Cochrane Library, Embase Web of Science. Eligibility criteria Randomised controlled trials exploring extraction synthesis Two independent reviewers employed standardised methods search, screen code included studies. The primary outcomes mortality during follow-up, 28-day mortality, need mechanical ventilation intensive care unit (ICU). secondary outcome length stay hospital ICU. risk bias was assessed using Risk Bias 2 tool. Depending on level heterogeneity, either random-effects model or fixed-effects applied. findings were summarised Grading Recommendations Assessment, Development Evaluation (GRADE) evidence profiles synthesised qualitatively. Results A total nine studies, comprising 870 participants, analysis. pooled results indicated associated lower (risk ratio 0.76; 95% CI 0.60 0.97). However, this apparent benefit not robust when examined through leave-one-out method trial sequential Regarding other outcomes, there no statistically significant difference between terms ICU admission. 0.41 day shorter (mean −0.41; −1.09 0.28) 0.07 −0.07; −0.61 0.46) compared supplementation; however, neither significant. Conclusion Based low moderate quality, reduced rate follow-up it did improve nor reduce admission, hospital. PROSPERO registration number CRD42024573791.

Язык: Английский

Процитировано

0
Constructing an early warning model for elderly sepsis patients based on machine learning DOI Creative Commons
Xuejie Ma, Yiu‐Wing Mai, Yin Ma

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 27, 2025

Sepsis is a serious threat to human life. Early prediction of high-risk populations for sepsis necessary especially in elderly patients. Artificial intelligence shows benefits early warning. The aim the study was construct an machine warning model patients and evaluate its performance. We collected from General Hospital Ningxia Medical University emergency department intensive care unit 01 January 2021 August 2023. clinical data divided into training set test set. A total 2976 12 features were screened. used 8 learning models build model. In conclusion, we developed based on XGBoost with AUROC 0.971, AUPRC 0.862, accuracy 0.95, specificity 0.964 F1 score 0.776. Of all features, baseline APTT played most important role, followed by lymphocyte count. Higher level lower count may indicate higher risk occurrence. high-performance old age order facilitate treatment but also need further external validation.

Язык: Английский

Процитировано

0
Immunohistochemical‐Based Molecular Typing of ACRG Combined With Immune‐Associated PD‐L1 Expression Can Predict the Prognosis of Gastric Cancer DOI Creative Commons

Fang Li,

Huiyan Deng, Zeqing Hu

и другие.

Cancer Medicine, Год журнала: 2025, Номер 14(7)

Опубликована: Апрель 1, 2025

ABSTRACT Background Gastric cancer (GC) is a molecularly heterogeneous disease with diverse clinical outcomes. Traditional classifications lack predictive accuracy, necessitating alternative molecular subtyping approaches for effective prognosis prediction. The Asian Cancer Research Group (ACRG) subtypes, combined immune‐associated PD‐L1 expression, offer promising framework to predict patient outcomes and potentially guide treatment strategies in GC. Methods This study retrospectively analyzed 1007 primary GC patients who underwent surgical resection between January 2017 June 2019 at the Fourth Hospital of Hebei Medical University. Comprehensive immunohistochemical fluorescent PCR‐capillary electrophoresis analyses were conducted determine ACRG subtypes (microsatellite instability [MSI], microsatellite stability epithelial–mesenchymal transition [MSS/EMT], MSS/TP53 + , − ) expression. We assessed relationship these various clinicopathological parameters, including survival outcomes, using Cox regression Kaplan–Meier analysis. Results showed significant associations features, tumor invasion depth, Lauren classification, HER2 status. MSI subtype (6.7% cases) was associated higher positivity favorable prognosis, whereas EMT had lowest 5‐year rate (34.55%) predominantly linked diffuse‐type histology. correlated worse independent value alongside (HR = 1.759, p 0.001; HR 5.144, < 0.001). Conclusion combination expression serves as an predictor facilitating tailored decision‐making. ACRG‐PD‐L1 classification system offers practical, cost‐effective approach routine application, providing critical insight into heterogeneity. Further multicenter studies are needed validate findings explore impact on therapy responses, particularly immunotherapy settings.

Язык: Английский

Процитировано

0