The influence of exercise intensity on comorbid anxious behavior in psychiatric conditions

The Journal of Physiological Sciences, Год журнала: 2024, Номер 74(1)

Опубликована: Авг. 2, 2024

Abstract Many experts have extensively studied the potential of exercise as a treatment option for psychiatric conditions, including depression and autism spectrum disorder (ASD). Despite their core symptoms, these conditions exhibits comparable component traits, an anxiety. In this study, we explored effect on behavioral abnormalities in focusing its intensity emotional resilience. Shank3B knockout (KO SED ) mice displaying self-injurious repetitive behavior C57BL/6J mice, susceptible to stress ASD model, respectively, were subjected moderate-intensity (ME) 2 weeks. ME mitigated symptoms (excessive grooming traits despair) but did not exert significant anxiolytic effect. Notably, has emerged critical determinant efficacy, evidenced by lower ventilation threshold mediated low-intensity exercise. The findings substantiate notion that is promising disease-modifying treatment, matters Graphical

Язык: Английский

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Considering comorbidities and individual differences in testing a gaming Behavioral Activation app for perinatal depression and anxiety: A pilot intervention study (Preprint)

JMIR Formative Research, Год журнала: 2024, Номер 9, С. e59154 - e59154

Опубликована: Ноя. 5, 2024

There is increasing interest in the development of scalable digital mental health interventions for perinatal populations to increase accessibility. Mobile behavioral activation (BA) efficacious treatment depression; however, effect comorbid anxiety and depression (CAD) on symptom trajectories remains underexplored. This important given that at least 10% women period experience CAD. We assessed whether there were differences pregnant participants with CAD as compared those only (ie, major depressive disorder [MDD]) during intervention a BA mobile gaming app. Pregnant adults either (n=10) or MDD (n=7) used app 10 weeks completed biweekly severity questionnaires anxiety. baseline diagnoses associated differential across study mixed effects longitudinal models. When controlling symptoms, results revealed significant interaction between diagnosis quadratic component week (β=.18, SE 0.07; t62=2.61; P=.01), revealing tendency group initially then decrease an accelerated rate, whereas symptoms relatively stable time. was linear time (β=-.39, 0.11; t68=-3.51; P=.001), showing declined steadily both groups. (β=-8.53, 3.93; t13=-2.17; P=.05), suggesting had higher follow-up when holding other predictors constant. The beneficial reducing individuals different comorbidity profiles. With respect trajectories, more variability. may be especially effective among CAD, it encourages in-the-moment ecologically relevant exposure anxiety-provoking stimuli. Despite no difference did not have reduction their period, some Findings point opportunities augmentation apps effectively target symptoms. Overall, findings suggest value considering comorbidities individual variations developing populations.

Язык: Английский

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Delay Discounting and Risk Tolerance in Obsessive Compulsive Disorder: Results From the Global OCD Study

Clinical Psychological Science, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 24, 2024

Although obsessive compulsive disorder (OCD) features maladaptive decision-making, previous research that examined economic decision-making in OCD has yielded inconsistent results. Here, we whether unmedicated adults with ( n = 268) differ from healthy control subjects (HCSs; 256) on two measures of about potential rewards: (a) delay discounting, the tendency to prefer rewards sooner rather than later, even if delayed reward is larger, and (b) risk tolerance, willingness gamble for uncertain when known. Data were collected Brazil, India, Netherlands, South Africa, United States as part Global study. After controlling age, sex, education, socioeconomic status, IQ, site, individuals did not HCSs either discounting or tolerance. However, patients who reported more anxiety depression showed higher a relative preference immediate rewards.

Язык: Английский

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Anxious Depression in Major Depressive Disorder: Key Influences and Prevalence in Chinese Hospitalized Patients

Neuropsychiatric Disease and Treatment, Год журнала: 2024, Номер Volume 20, С. 2267 - 2275

Опубликована: Ноя. 1, 2024

Anxious depression (AUD) is a common subtype of major depressive disorder (MDD) and has significant negative impact on disease progression patient prognosis. Our study aimed to determine the frequency AUD in Chinese patients with MDD during their first hospitalization identify factors that may influence emergence intensity these AUD.

Язык: Английский

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[Applications and challenges of wearable electroencephalogram signals in depression recognition and personalized music intervention].

PubMed, Год журнала: 2023, Номер 40(6), С. 1093 - 1101

Опубликована: Дек. 25, 2023

Rapid and accurate identification effective non-drug intervention are the worldwide challenges in field of depression. Electroencephalogram (EEG) signals contain rich quantitative markers depression, but whole-brain EEG acquisition process is too complicated to be applied on a large-scale population. Based wearable frontal lobe monitoring device developed by authors' laboratory, this study discussed application signal depression recognition intervention. The technical principle commonly used devices were introduced. Key technologies for signals-based existing limitations reviewed discussed. Finally, closed-loop brain-computer music interface system personalized was proposed, further This review paper may contribute transformation relevant theories from basic research application, advance screening intervention.如何实现快速准确的识别和有效的非药物干预是目前抑郁症领域亟待解决的难题。脑电信号蕴藏丰富的抑郁症定量标记，但全脑脑电信号的采集操作过程繁琐，不易应用于大规模人群。本文基于笔者课题组自主研发的可穿戴额叶脑电信号监测设备及其在抑郁症识别和干预中的应用展开讨论，介绍可穿戴脑电信号监测设备的技术原理和常见类型，综述基于可穿戴脑电信号的抑郁症识别关键技术及其存在的技术瓶颈。最后，本文提出一种面向抑郁症个性化干预的闭环脑机音乐接口系统，并进一步探讨了其所面临的技术挑战。本文有助于促进相关理论和技术从基础研究向应用转化，推动抑郁症筛查和个性化干预的进程。.

Язык: Английский

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