Influence of comorbidity on the quality of life of patients with osteoarthritis DOI
Ирина Ивановна Соколова

Experimental and Clinical Medicine, Год журнала: 2023, Номер 93(2), С. 27 - 33

Опубликована: Апрель 1, 2023

OsteoArthrosis (OA) is the most common joint disease in many populations and one of main causes incapacity for work among citizens Ukraine, which usually manifests itself people over 40 years age. Therefore, problem OA has gained special importance relevance due to its significant prevalence, rapid development functional disorders disability different ages. Using screening method, it was found that every second patient with a chronic internal organs OA, therefore attention scientists focused on issues comorbidity influence course patient's satisfaction Quality Life (QoL). A survey conducted 100 patients at rheumatology department Chernivtsi city Clinical Hospital No.3, 30 Practically Healthy Persons (PHP), who were given MOS SF-36 questionnaires (Medical Outcome Study Short Form-36) KOOS (Knee injury Osteoarthritis Score), had answer questions based their own thoughts feelings about asked. The results indicate decrease indicators physical psychological components health all groups compared PHP. These are also significantly reduced arterial hypertension type 2 diabetes isolated OA. Evaluation questionnaire indicated expressed dissatisfaction quality life. Based study, conclusion made negative impact concomitant pathology need routine use early detection QoL deterioration timely provision necessary medical care. Keywords: comorbidity, life, SF-36, KOOS, osteoarthritis.

Язык: Английский

The Role of Platelet Concentrates and Growth Factors in Facial Rejuvenation: A Systematic Review with Case Series DOI Creative Commons
Giuseppina Malcangi, Angelo Michele Inchingolo, Alessio Danilo Inchingolo

и другие.

Medicina, Год журнала: 2025, Номер 61(1), С. 84 - 84

Опубликована: Янв. 7, 2025

Background and objectives: Due to the regeneration potential of growth factors (GFs) platelet concentrates (PCs), facial rejuvenation has been a major area attention in esthetic medicine. The effectiveness safety PCs GFs promoting face are examined this systematic review, which is complemented by case series. essential for collagen production dermal matrix remodeling, while PCs, like Platelet-Rich Plasma (PRP), abundant bioactive chemicals that promote tissue healing cellular regeneration. Materials Methods: A comprehensive literature search was performed on PubMed, Web Science, Scopus, focusing human clinical trials published between February 2019 2024 related PRP esthetics. Results: Thirteen studies met inclusion criteria were analyzed. Conclusions: review summarizes most recent data patient outcomes, treatment regimens, possible hazards. series goes with it shows real-world examples how improve skin elasticity, texture, general appearance little negative side effects. These results highlight use as minimally invasive procedures.

Язык: Английский

Процитировано

1
Effectiveness of Herbal Medicines with Anti-Inflammatory, Antimicrobial, and Antioxidant Properties in Improving Oral Health and Treating Gingivitis and Periodontitis: A Systematic Review DOI Open Access
Giuseppina Malcangi, Angelo Michele Inchingolo, Lucia Casamassima

и другие.

Nutrients, Год журнала: 2025, Номер 17(5), С. 762 - 762

Опубликована: Фев. 21, 2025

Objectives: This systematic review investigates the effectiveness of natural extracts with anti-inflammatory properties for improving oral health, particularly in managing gingivitis and periodontal disease (PD). With PD being a major global health issue, exacerbated by microbial dysbiosis oxidative stress, integration phytochemicals herbal formulations into therapy offers promising avenue adjunctive treatments. Methods: A was conducted following PRISMA guidelines registered under International Prospective Register Systematic Reviews (ID: 641944). Databases, including PubMed, Scopus, Web Science, were searched between 18–24 December 2024, using Boolean keywords combining terms such as “herbal medicine”, “plant extracts”, “anti-inflammatory”, “periodontal therapy”. Studies involving animal models, vitro data, or non-peer-reviewed articles excluded. Results: Seventeen studies met inclusion criteria. Polyherbal single-component (e.g., Camellia sinensis, Punica granatum, Zingiber officinale, Rosmarinus officinalis) demonstrated comparable efficacy to conventional agents like chlorhexidine (CHX). rinses, camellia sinensis gels, granatum reduced inflammation, improved gingival showed antimicrobial properties, offering effective alternatives. Conclusions: Natural products, single polyherbal formulations, provide safe alternatives PD. Their anti-inflammatory, antimicrobial, antioxidant support their role alongside scaling root planning (SRP) therapy. However, further large-scale, long-term are needed standardize establish optimal protocols.

Язык: Английский

Процитировано

0
Recent advances in the management of knee osteoarthritis: a narrative review DOI Creative Commons
Viktor Shtroblia, Pavlo Petakh, Iryna Kamyshna

и другие.

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Янв. 21, 2025

Knee osteoarthritis (OA) is a common condition that causes pain and reduces the quality of life for many people. It also leads to high health financial costs. Managing knee OA requires using different methods together best results. This review overviews current therapeutic options pain, focusing on their efficacy, safety, potential roles in clinical practice. Topical treatments, such as NSAIDs capsaicin, offer significant relief with minimal systemic side effects are suitable initial therapy, nonpharmacologic interventions like exercise and, when relevant, weight loss. Oral analgesics, including acetaminophen opioids, have limited efficacy serious effects, making them appropriate only short-term or rescue therapy. Intra-articular injections, corticosteroids, hyaluronic acid, platelet rich plasma, demonstrate varying levels safety. Nutritional supplements, curcumin, Boswellia serrata , glucosaminechondroitin combinations, modest benefits used adjuncts standart treatment. Nonpharmacological transcutaneous electrical nerve stimulation (TENS), acupuncture, local heat provide variable should be customized based individual patient responses. Targeted biologic agents, antibodies TNF-α, IL-1, NGF, hold promise more precise relief; however, further research required establish routine use. Treating personalized, combining several methods. Research must continue improve treatments make safer.

Язык: Английский

Процитировано

0
Gut and Joint Microbiomes DOI
Honey Hendesi, David A. Villani, Janne Prawitt

и другие.

Rheumatic Disease Clinics of North America, Год журнала: 2025, Номер 51(2), С. 295 - 324

Опубликована: Март 6, 2025

Язык: Английский

Процитировано

0
The Gut Microbiota’s Role in Neurological, Psychiatric, and Neurodevelopmental Disorders DOI Open Access
Ioannis Alexandros Charitos, Angelo Michele Inchingolo, Laura Ferrante

и другие.

Nutrients, Год журнала: 2024, Номер 16(24), С. 4404 - 4404

Опубликована: Дек. 22, 2024

Aim: This article aims to explore the role of human gut microbiota (GM) in pathogenesis neurological, psychiatric, and neurodevelopmental disorders, highlighting its influence on health disease, investigating potential therapeutic strategies targeting GM modulation. Materials Methods: A comprehensive analysis microbiota’s composition interaction with body, particularly, neurological psychiatric conditions, is provided. The review discusses factors influencing composition, including birth mode, breastfeeding, diet, medications, geography. Additionally, it examines GM’s functions, such as nutrient absorption, immune regulation, pathogen defense, alongside interactions nervous system through gut–brain axis, neurotransmitters, short-chain fatty acids (SCFAs). Results: Alterations are linked various Parkinson’s multiple sclerosis, depression, schizophrenia, ADHD, autism. influences cognitive stress responses, mood regulation. Antibiotic use disrupts diversity, increasing risk metabolic obesity, allergic diseases. Emerging therapies probiotics, prebiotics, transplantation show promise modulating alleviating symptoms conditions. Conclusions. modulation represents a promising approach for personalized treatment strategies. Further research needed better understand underlying mechanisms develop targeted aimed at restoring balance improved clinical outcomes.

Язык: Английский

Процитировано

1
Association of autoimmune diseases with the occurrence of osteoarthritis: a gene expression and Mendelian randomization study DOI Creative Commons

Dan Jing,

Huai Min Lu,

Xun Zhou

и другие.

Frontiers in Medicine, Год журнала: 2024, Номер 11

Опубликована: Сен. 5, 2024

Observational studies have indicated a potential association between autoimmune diseases and the occurrence of Osteoarthritis (OA), with an increased risk mortality among affected patients. However, whether causal relationship exists two remains unknown.

Язык: Английский

Процитировано

0
Influence of comorbidity on the quality of life of patients with osteoarthritis DOI
Ирина Ивановна Соколова

Experimental and Clinical Medicine, Год журнала: 2023, Номер 93(2), С. 27 - 33

Опубликована: Апрель 1, 2023

OsteoArthrosis (OA) is the most common joint disease in many populations and one of main causes incapacity for work among citizens Ukraine, which usually manifests itself people over 40 years age. Therefore, problem OA has gained special importance relevance due to its significant prevalence, rapid development functional disorders disability different ages. Using screening method, it was found that every second patient with a chronic internal organs OA, therefore attention scientists focused on issues comorbidity influence course patient's satisfaction Quality Life (QoL). A survey conducted 100 patients at rheumatology department Chernivtsi city Clinical Hospital No.3, 30 Practically Healthy Persons (PHP), who were given MOS SF-36 questionnaires (Medical Outcome Study Short Form-36) KOOS (Knee injury Osteoarthritis Score), had answer questions based their own thoughts feelings about asked. The results indicate decrease indicators physical psychological components health all groups compared PHP. These are also significantly reduced arterial hypertension type 2 diabetes isolated OA. Evaluation questionnaire indicated expressed dissatisfaction quality life. Based study, conclusion made negative impact concomitant pathology need routine use early detection QoL deterioration timely provision necessary medical care. Keywords: comorbidity, life, SF-36, KOOS, osteoarthritis.

Язык: Английский

Процитировано

0