Translational Vision Science & Technology,
Год журнала:
2025,
Номер
14(1), С. 5 - 5
Опубликована: Янв. 9, 2025
Purpose:
Previous
researches
have
suggested
an
important
association
between
gut
microbiota
(GM)
and
vascular
pathologies
such
as
atherosclerosis.
This
study
aimed
to
explore
the
196
GM
taxa
retinal
vein
occlusion
(RVO).
Methods:
used
Mendelian
randomization
(MR),
linkage
disequilibrium
score
regression
(LDSC),
polygenic
overlap
analysis.
Genome-wide
(GWAS)
data
associated
with
was
obtained
from
MiBioGen
consortium,
involving
a
large
number
of
European-ancestry
participants.
GWAS
RVO
FinnGen
consortium
another
that
also
involved
Inverse-variance
weighted
primary
approach
for
MR
estimation.
Moreover,
LDSC
analyses
were
performed
evaluate
genetic
correlation
RVO.
Results:
The
results
identified
six
taxa,
including
class
Bacilli,
order
Lactobacillales,
family
Streptococcaceae,
genus
Clostridium
innocuum
group,
Family
XIII
AD3011
Subdoligranulum
development
In
addition,
analysis
supported
Conclusions:
Our
findings
confirmed
RVO,
thereby
highlighting
effects
on
health.
Translational
Relevance:
may
provide
rationale
developing
GM-based
strategies
preventing
onset
Journal of Clinical Medicine,
Год журнала:
2022,
Номер
11(16), С. 4889 - 4889
Опубликована: Авг. 20, 2022
Dry
eye
is
considered
an
inflammatory
disease.
Gut
microbiota
are
important
in
the
regulation
of
low-grade
chronic
inflammation,
including
eye.
Probiotics
and
prebiotics
increasingly
used
to
regulate
chronic-disease-associated
gut
dysbiosis.
Therefore,
this
double-masked,
randomized
controlled
clinical
trial
aimed
explore
potential
oral
probiotics
management
dry
In
total,
41
participants
with
received
probiotic
prebiotic
supplements
(treatment
group,
n
=
23)
or
respective
placebos
(control
18)
for
4
months.
symptoms
signs
were
evaluated
using
Ocular
Surface
Disease
Index
(OSDI),
Eye
Questionnaire
5,
osmolarity,
non-invasive
keratograph
break-up
time
(NIKBUT),
ocular
surface
staining,
tear
meniscus
height
(TMH),
lipid
layer
thickness,
conjunctival
redness.
After
months,
average
OSDI
score
treatment
group
was
significantly
better
compared
that
controls
(16.8
±
5.9
vs.
23.4
7.4;
p
<
0.001).
The
NIKBUT
TMH
did
not
change
(p
0.31
0.84)
but
reduced
on
by
−5.5
1.0
secs
0.03)
0.2
0.1
mm
0.02).
These
data
suggest
might
be
effective
Life,
Год журнала:
2023,
Номер
13(4), С. 968 - 968
Опубликована: Апрель 7, 2023
Diabetic
retinopathy
is
one
of
the
major
causes
blindness
today,
despite
important
achievements
in
diagnosis
and
therapy.
The
involvement
a
gut–retina
axis
thought
to
be
possible
risk
factor
for
several
chronic
eye
disease,
such
as
glaucoma,
age-related
macular
degeneration,
uveitis,
and,
recently,
diabetic
retinopathy.
Dysbiosis
may
cause
endothelial
disfunction
alter
retinal
metabolism.
This
review
analyzes
evidence
regarding
changes
gut
microbiota
patients
with
DR
compared
diabetics
healthy
controls
(HCs).
A
systematic
was
performed
on
PubMed,
Web
Science,
Google
Scholar
following
terms:
“gut
microbiota”
OR
microbiome”
AND
“diabetic
retinopathy”.
Ultimately,
9
articles
published
between
2020
2022
presenting
comparative
data
total
228
T2DM
DR,
220
T2DM,
118
HCs
were
analyzed.
All
studies
found
distinctive
microbial
beta
diversity
vs.
HC,
characterized
by
an
altered
Firmicutes/Bacteroidetes
ratio,
decrease
butyrate
producers,
increase
LPS-expressing
pro-inflammatory
species
Bacteroidetes
Proteobacteria
phyla.
probiotic
Bifidobacterium
Lactobacillus
decreased
when
T2DM.
Gut
influence
health
multiple
ways
represent
future
therapeutic
target
DR.
Frontiers in Endocrinology,
Год журнала:
2023,
Номер
14
Опубликована: Июль 4, 2023
Diabetic
retinopathy
(DR)
is
a
microvascular
lesion
that
occurs
as
complication
of
diabetes
mellitus.
Many
studies
reveal
retinal
neurodegeneration
early
in
its
pathogenesis,
and
abnormal
function
can
occur
patients
without
any
signs
abnormalities.
The
gut
microbiota
large,
diverse
colony
microorganisms
colonize
the
human
intestine.
Studies
indicated
involved
pathophysiological
processes
DR
plays
an
important
role
development.
On
one
hand,
numerous
demonstrated
involvement
neurodegeneration.
other
alterations
bacteria
RD
cause
or
exacerbate
DR.
present
review
aims
to
underline
critical
relationship
between
After
brief
overview
composition,
function,
essential
ocular
health,
explores
concept
gut-retina
axis
conditions
crosstalk.
Because
dysbiosis
has
been
associated
with
DR,
intends
determine
changes
microbiome
hypothesized
mechanisms
linking
axis,
predictive
potential.
Translational Vision Science & Technology,
Год журнала:
2025,
Номер
14(1), С. 5 - 5
Опубликована: Янв. 9, 2025
Purpose:
Previous
researches
have
suggested
an
important
association
between
gut
microbiota
(GM)
and
vascular
pathologies
such
as
atherosclerosis.
This
study
aimed
to
explore
the
196
GM
taxa
retinal
vein
occlusion
(RVO).
Methods:
used
Mendelian
randomization
(MR),
linkage
disequilibrium
score
regression
(LDSC),
polygenic
overlap
analysis.
Genome-wide
(GWAS)
data
associated
with
was
obtained
from
MiBioGen
consortium,
involving
a
large
number
of
European-ancestry
participants.
GWAS
RVO
FinnGen
consortium
another
that
also
involved
Inverse-variance
weighted
primary
approach
for
MR
estimation.
Moreover,
LDSC
analyses
were
performed
evaluate
genetic
correlation
RVO.
Results:
The
results
identified
six
taxa,
including
class
Bacilli,
order
Lactobacillales,
family
Streptococcaceae,
genus
Clostridium
innocuum
group,
Family
XIII
AD3011
Subdoligranulum
development
In
addition,
analysis
supported
Conclusions:
Our
findings
confirmed
RVO,
thereby
highlighting
effects
on
health.
Translational
Relevance:
may
provide
rationale
developing
GM-based
strategies
preventing
onset
