Revisiting the renin-angiotensin-aldosterone system in the eye: mechanistic insights and pharmacological targets DOI Creative Commons
Francesco Buonfiglio, Elsa Wilma Böhm, Qi Tang

и другие.

Pharmacological Research, Год журнала: 2025, Номер 216, С. 107771 - 107771

Опубликована: Май 9, 2025

The renin-angiotensin-aldosterone system (RAAS) plays a fundamental role in regulating blood pressure and fluid homeostasis through key effectors such as angiotensin II aldosterone. These agents their receptors have become crucial molecular targets several cardiovascular renal diseases. Over the past few decades, growing body of evidence has revealed presence RAAS components ocular structures, suggesting tissue-specific within eye. Building on this knowledge, studies indicated that significant pathogenesis various eye An impaired overactivated contributes to development severe widespread disorders affecting both anterior posterior segments In context, current work aims delve into pivotal pathways involving RAAS, with an in-depth exploration pathophysiology. It focuses relationship between overactivation oxidative stress, well exacerbation neovascularization inflammatory processes. objective is provide updated comprehensive understanding ophthalmological diseases, highlighting therapeutic potential modulators discussing controversies challenges area research.

Язык: Английский

Revisiting the renin-angiotensin-aldosterone system in the eye: mechanistic insights and pharmacological targets DOI Creative Commons
Francesco Buonfiglio, Elsa Wilma Böhm, Qi Tang

и другие.

Pharmacological Research, Год журнала: 2025, Номер 216, С. 107771 - 107771

Опубликована: Май 9, 2025

The renin-angiotensin-aldosterone system (RAAS) plays a fundamental role in regulating blood pressure and fluid homeostasis through key effectors such as angiotensin II aldosterone. These agents their receptors have become crucial molecular targets several cardiovascular renal diseases. Over the past few decades, growing body of evidence has revealed presence RAAS components ocular structures, suggesting tissue-specific within eye. Building on this knowledge, studies indicated that significant pathogenesis various eye An impaired overactivated contributes to development severe widespread disorders affecting both anterior posterior segments In context, current work aims delve into pivotal pathways involving RAAS, with an in-depth exploration pathophysiology. It focuses relationship between overactivation oxidative stress, well exacerbation neovascularization inflammatory processes. objective is provide updated comprehensive understanding ophthalmological diseases, highlighting therapeutic potential modulators discussing controversies challenges area research.

Язык: Английский

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