Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Янв. 25, 2024
Abstract
The
study
aimed
to
assess
the
efficacy
of
transcranial
direct
current
stimulation
(tDCS)
in
treatment
neuropsychiatric
(NP)
symptoms
post-acute
sequelae
SARS-CoV-2
infection
(PASC),
known
as
long
COVID.
A
double-blind,
randomized,
sham-controlled
compared
and
safety
prefrontal
cortex
active
tDCS
sham-tDCS
treating
NP-PASC.
Patients
diagnosed
with
NP-PASC,
a
Fatigue
Impact
Scale
(FIS)
score
≥
40,
were
eligible
for
study.
Twenty
sessions
administered
within
four
weeks,
continuous,
end-of-treatment,
follow-up
measurements.
primary
outcome
was
change
FIS
at
analyzed
intention-to-treat
population.
Data
from
33
patients
assigned
(n
=
16)
or
17)
analyzed.
After
treatment,
decrease
more
pronounced
sham
than
group,
yet
intergroup
difference
insignificant
(11.7
[95%
CI
−11.1
34.5],
p
0.6).
Furthermore,
no
significant
differences
observed
regarding
anxiety,
depression,
quality
life,
cognitive
performance.
small
cohort
sample,
baseline
scores
between
groups
(non-stratified
randomization),
chosen
parameters
may
have
influenced
our
findings.
However,
it
might
also
be
possible
that
expected
mechanism
action
is
insufficient
treat
these
conditions.
Journal of Clinical Medicine,
Год журнала:
2022,
Номер
11(21), С. 6554 - 6554
Опубликована: Ноя. 4, 2022
Long
COVID
is
a
clinical
syndrome
characterized
by
profound
fatigue,
neurocognitive
difficulties,
muscle
pain,
weakness,
and
depression,
lasting
beyond
the
3–12
weeks
following
infection
with
SARS-CoV-2.
Among
symptoms,
psychiatric
sequelae,
including
attention
memory
alterations,
as
well
anxiety
depression
have
become
major
targets
of
current
healthcare
providers
given
significant
public
health
impact.
In
this
context,
assessment
tools
play
crucial
role
in
early
screening
cognitive
alterations
due
to
COVID.
others,
general
tools,
such
Montreal
Cognitive
assessment,
more
specific
ones,
State
Trait
Inventory
Fatigue
Digit
Span,
may
be
help
investigating
main
alterations.
Moreover,
appropriate
neurorehabilitative
programs
using
methods
techniques
(conventional
and/or
advanced)
through
multidisciplinary
team
are
required
treat
COVID-19-related
behavioral
abnormalities.
narrative
review,
we
sought
describe
symptoms
provide
some
advice
for
treatment
American Journal of Physical Medicine & Rehabilitation,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 3, 2024
ABSTRACT
Objective
To
determine
the
effects
of
Enhanced
External
Counterpulsation
(EECP)
in
patients
with
long
COVID
and
objectively
assessed
cognitive
impairment.
Design
A
retrospective
evaluation
referred
for
EECP,
sequela,
having
completed
an
objective
digital
assessment
before
after
therapy.
Patients
had
either
impairment
(CI)
or
no
(NCI)
at
baseline.
We
changes
composite
score
using
multi-factor
ANOVA.
Multiple
linear
logistic
regression
analyses
were
conducted
to
evaluate
several
independent
variables.
Results
80
(38
CI
vs
42
NCI)
included
analyses.
All
baseline
characteristics
well
matched.
There
was
significant
improvement
post-EECP
those
notable
documented
safety
concerns.
Conclusion
This
is
first
study
showing
that
EECP
led
functioning
defined
Although
a
lack
negative
control
group
limitation
this
study,
appears
be
highly
safe
effective
potential
widespread
application.
CNS Neuroscience & Therapeutics,
Год журнала:
2025,
Номер
31(3)
Опубликована: Март 1, 2025
ABSTRACT
Background
The
COVID‐19
pandemic
has
left
an
indelible
mark
on
the
world,
with
mounting
evidence
suggesting
that
it
not
only
posed
acute
challenges
to
global
healthcare
systems
but
also
unveiled
a
complex
array
of
long‐term
consequences,
particularly
cognitive
impairment
(CI).
As
persistence
post‐COVID‐19
neurological
syndrome
could
evolve
into
next
public
health
crisis,
is
imperative
gain
better
understanding
intricate
pathophysiology
CI
in
patients
and
viable
treatment
strategies.
Methods
This
comprehensive
review
explores
management
across
phases
COVID‐19,
from
infection
Long‐COVID,
by
synthesizing
findings
clinical,
preclinical,
mechanistic
studies
identify
key
contributors
CI,
as
well
current
therapeutic
approaches.
Results
Key
mechanisms
contributing
include
persistent
neuroinflammation,
cerebrovascular
complications,
direct
neuronal
injury,
activation
kynurenine
pathway,
psychological
distress.
Both
pharmacological
interventions,
such
anti‐inflammatory
therapies
agents
targeting
neuroinflammatory
pathways,
non‐pharmacological
strategies,
including
rehabilitation,
show
promise
addressing
these
challenges.
Although
much
derived
preclinical
animal
studies,
provide
foundational
insights
potential
Conclusion
By
knowledge,
this
highlights
importance
COVID‐19‐related
offers
actionable
for
mitigation
recovery
community
continues
grapple
pandemic's
impact.
Deleted Journal,
Год журнала:
2025,
Номер
16(1), С. 3 - 13
Опубликована: Март 30, 2025
Introduction
This
literature
review
examines
the
profound
impact
of
Covid-19,
caused
by
SARS-CoV-2,
on
nervous
system.
While
virus
is
predominantly
associated
with
respiratory
complications,
emerging
evidence
highlights
its
strong
neurotropic
potential,
leading
to
a
broad
spectrum
neurological
disorders.
explores
convergence
virology
and
neurology,
emphasizing
both
acute
long-term
consequences
disease.
Methods
A
systematic
following
PRISMA
guidelines
was
conducted
using
databases
such
as
PubMed,
Scopus,
Web
Science.
Studies
were
selected
based
their
relevance
pathophysiology,
clinical
presentations,
prolonged
effects
Covid-19.
Preference
given
peer-reviewed
research,
including
meta-analyses
case
reports
published
between
2020
2024.
Results
The
identifies
various
pathways
through
which
SARS-CoV-2
affects
system,
direct
neuroinvasion
systemic
inflammatory
responses.
Acute
conditions
encephalitis,
stroke,
Guillain-Barré
syndrome
have
been
frequently
reported,
while
chronic
complications
include
cognitive
dysfunction,
neurodegenerative
disorders,
psychiatric
disturbances.
These
findings
highlight
intricate
enduring
burden
Conclusion
Neuro-Covid
presents
an
ongoing
challenge
in
post-pandemic
landscape.
deeper
understanding
implications
essential
for
enhancing
patient
management
shaping
future
research
directions.
importance
increased
vigilance
multidisciplinary
strategy
effectively
address
complex
evolving
Covid-19-related
The Clinical Neuropsychologist,
Год журнала:
2024,
Номер
unknown, С. 1 - 29
Опубликована: Авг. 23, 2024
The
coronavirus
disease-2019
(COVID-19)
pandemic,
caused
by
severe
acute
respiratory
syndrome
coronavirus-2
(SARS-CoV-2),
has
had
a
profound
global
impact
on
individual
health
and
well-being
in
adults
children.
While
most
fully
recover
from
COVID-19,
relatively
large
subgroup
continues
to
experience
persistent
physical,
cognitive,
emotional/behavioral
symptoms
beyond
the
initial
infection
period.
World
Health
Organization
termed
this
phenomenon
"Post-COVID-19
Condition"
(PCC),
better
known
as
"Long
COVID."
Due
cognitive
psychosocial
symptoms,
neuropsychologists
often
assess
recommend
treatment
for
individuals
with
Long
COVID.
However,
guidance
neuropsychologists'
involvement
clinical
care,
policy-making,
research
not
yet
been
developed.
authors
of
manuscript
convened
address
critical
gap
develop
working
patients
presenting
Seminars in Respiratory and Critical Care Medicine,
Год журнала:
2023,
Номер
44(01), С. 130 - 142
Опубликована: Янв. 16, 2023
Abstract
Post-COVID
conditions
continue
to
afflict
patients
long
after
acute
severe
respiratory
syndrome-coronavirus-2
(SARS
CoV-2)
infection.
Over
50
symptoms
across
multiple
organ
systems
have
been
reported,
with
pulmonary,
cardiovascular,
and
neuropsychiatric
sequelae
occurring
most
frequently.
Multiple
terms
used
describe
post-COVID
including
COVID,
long-haul
postacute
coronavirus
disease
2019
(COVID-19),
of
SARS-CoV-2
infection,
long-term
effects
chronic
COVID-19;
however,
standardized
assessments
treatment
algorithms
for
generally
lacking.
This
review
discusses
the
epidemiology
risk
factors
provides
a
general
overview
diagnostic
assessment
specific
manifestations.
Data
derived
from
multitude
observational
studies
scientific
investigations
into
pathogenesis
are
providing
clearer
understanding
distinct
phenotypes
conditions.
Insight
gained
these
ongoing
interventional
trials
continues
lead
development
clinical
protocols
directed
toward
improving
COVID-19
survivors'
quality
life
preventing
or
reducing
morbidity.
European Journal of Physical and Rehabilitation Medicine,
Год журнала:
2022,
Номер
58(6)
Опубликована: Дек. 19, 2022
Currently,
no
evidence
exists
on
specific
treatments
for
post
COVID-19
condition
(PCC).
However,
rehabilitation
interventions
that
are
effective
similar
symptoms
in
other
health
conditions
could
be
applied
to
people
with
PCC.
With
this
overview
of
systematic
reviews
mapping,
we
aimed
describe
the
Cochrane
proposed
cognitive
impairment,
anxiety
and
depression
different
can
relevant
JAMA Network Open,
Год журнала:
2023,
Номер
6(8), С. e2327750 - e2327750
Опубликована: Авг. 7, 2023
The
COVID-19
pandemic
caused
large
disruptions
to
health
care
for
hospitalized
older
adults.
incidence
and
management
of
delirium
may
have
been
affected
by
high
rates
infection,
staffing
shortages,
overwhelmed
hospital
capacity,
changes
visitor
policies.