Neurorehabilitation,
Год журнала:
2023,
Номер
53(4), С. 517 - 534
Опубликована: Дек. 19, 2023
BACKGROUND:
Duration
of
neuropsychological
disorders
caused
by
long
COVID,
and
the
variables
that
impact
outcomes,
are
still
largely
unknown.
OBJECTIVE:
To
describe
cognitive
profile
patients
with
COVID
post-participation
in
a
rehabilitation
program
subsequent
reassessment
identify
factors
influence
recovery.
METHODS:
208
(mean
age
48.8
y.o.),
mostly
female,
were
reevaluated
25
months
after
their
first
infection
17
initial
evaluation.
Patients
underwent
subjective
assessment,
Barrow
Neurological
Institute
Screen
for
Higher
Cerebral
Functions
(BNIS),
Phonemic
Verbal
Fluency
Clock
Drawing
Tests
(NEUPSILIN)
executive
functions,
Hospital
Anxiety
Depression
Scale
(HADS)
WHOQol-Bref.
RESULTS:
We
noted
discrete
improvement
symptoms
acute
stage
COVID-19;
nonetheless,
performance
was
not
within
normative
parameters
standardized
testing.
These
results
negatively
QoL
corroborate
patients’
assessments
issues
experienced
daily
life.
Improvement
seen
those
who
participated
psychoeducational
rehabilitation,
had
higher
levels
education,
lower
depression
scores
on
HADS.
CONCLUSION:
Our
data
reveal
persistence
long-term
neuropsychiatric
COVID.
Neuropsychological
is
shown
to
be
important,
whether
in-person
or
online.
Dementia & Neuropsychologia,
Год журнала:
2024,
Номер
18
Опубликована: Янв. 1, 2024
ABSTRACT.
COVID-19
is
a
multisystem
disease
caused
by
the
RNA
virus
(coronavirus
2
or
SARS-CoV-2)
that
can
impact
cognitive
measures.
Objective:
To
identify
main
and
neuropsychiatric
symptoms
in
adults
who
had
no
complaints
prior
to
infection.
Specifically,
observe
trajectory
of
performance
after
6
months.
Methods:
This
retrospective
longitudinal
study.
Forty-nine
patients
(29
reassessed
months),
with
positive
PCR
test,
only
presented
infection
without
history
structural,
neurodegenerative
psychiatric
neurological
diseases.
A
brief
assessment
battery
(MoCA),
Trail
Making
Test
(TMT-A,
B,
∆),
Verbal
Fluency
were
used,
as
well
scales
(Hospital
Anxiety
Depression
Scale-HADS,
Fatigue
Severity
Scale-FSS).
Correlation
tests
group
comparison
used
for
descriptive
inferential
statistics.
Level
significance
α=5%.
Results:
Mean
age
50.4
(11.3),
12.7
(2.8)
years
education,
higher
percentage
women
(69.8%).
No
psycho-emotional
improvement
(depression
anxiety)
was
observed
between
evaluations,
maintained
subjective
complaint
changes.
The
HAD-Anxiety
scale
showed
significant
correlation
TMT-B
errors.
subgroup
participating
stimulation
psychoeducation
global
cognition
measure
executive
attention
test.
Conclusion:
Our
results
corroborate
other
studies
found
dysfunctions
post-COVID-19
persist
months
remission,
symptoms,
even
individuals
mild
Future
studies,
an
increase
casuistry
control
samples,
are
necessary
greater
evidence
these
results.
Vaccines,
Год журнала:
2023,
Номер
11(6), С. 1077 - 1077
Опубликована: Июнь 8, 2023
Serological
assays
have
been
used
to
evaluate
the
magnitude
of
naturally
acquired
and
BNT162b2
vaccine-induced
immunity.
In
order
assess
extent
which
antibody
response
correlates
with
infection-mediated
protection
after
vaccination,
we
investigated
kinetics
anti-SARS-CoV-2-S1
IgG
in
fully
vaccinated
healthy
individuals
who
did
or
not
develop
COVID-19
within
8
months
booster
dose.
The
receptor-binding,
domain-specific
titer
was
assessed
serum
samples
collected
at
various
intervals
from
4
second
6
third
level
decreased
33%
dose
and,
one
month
dose,
increased
dramatically
(>300%)
compared
pre-booster
time
point.
infection
two
cause
significant
variation,
but
later
viral
infections
elicited
an
similar
initial
booster.
probability
developing
severity
symptoms
were
related
titer.
Our
data
indicate
that
repeated
exposure
antigens
by
either
vaccination
short-term
elicits
limited
boosting
effects
alone
is
associated
prediction
future
their
symptomatology.
Contemporary Clinical Trials,
Год журнала:
2022,
Номер
122, С. 106955 - 106955
Опубликована: Окт. 5, 2022
Post-COVID-19
condition
is
frequently
comprised
of
persistent
cognitive
sequela,
including
deficits
in
attention
and
executive
functions
(EFs),
which
can
act
as
a
barrier
for
regaining
pre-illness
functional
levels.
Goal
Management
Training
(GMT)
rehabilitation
(CR)
intervention
improving
EFs
that
has
received
empirical
support
studies
other
patient
groups.
The
present
study
aims
to
determine
the
efficacy
GMT
everyday
adults
who
experience
after
COVID-19.
This
protocol
describes
an
open-label
randomized
controlled
trial
comparing
wait
list
control
(WL),
(>
2
months)
sequela
post-COVID-19
condition.
recruit
240
participants
aged
18
65
years
with
history
SARS-CoV-2
infection
perceived
attentional
EF
difficulties
daily
life.
Participants
will
be
block
(computer-algorithm)
either
group-based
(n
=
120)
or
WL
120).
internet-delivered
groups
six
two-hour
sessions
delivered
once
week.
primary
outcome
Metacognition
Index
Behavior
Rating
Inventory
Executive
Function
–
Adult
Version,
self-report
measure
assessing
difficulties,
specifically
metacognition,
at
months
post-treatment.
Secondary
outcomes
include
performance-based
neurocognitive
measures,
tertiary
rating
scales
cognition,
emotional
health,
quality
life,
fatigue.
Study
findings
could
contribute
providing
evidence-based
treatment
option
symptoms
are
frequent
debilitating
following
prevalent
NCT05494424
Oxford University Press eBooks,
Год журнала:
2024,
Номер
unknown, С. 163 - 182
Опубликована: Окт. 10, 2024
Abstract
Cognitive
impairment
is
commonly
reported
among
tuberculous
meningitis
(TBM)
survivors.
Motor
control,
memory,
language,
attention,
and
decision-making
are
a
few
of
the
complex
functions
human
brain
that
may
be
affected
by
TBM.
Focal
lesions
or
diffuse
processes
due
to
invasion
Mycobacterium
tuberculosis
underline
these
cognitive
deficits.
While
measuring
function
in
acute
phase
difficult
TBM
hyperinflammation,
it
relevant
for
prompt
detection
intervention
post-acute
preparing
patients’
long-term
when
they
return
productive
daily
activities.
The
best
tools
identify
detailed
can
guide
clinician
toward
personal
rehabilitation
program
await
further
research,
especially
ones
affordable
low-resource
population
where
predominant.
Ukrainian Neurosurgical Journal,
Год журнала:
2024,
Номер
30(4), С. 3 - 10
Опубликована: Дек. 30, 2024
Introduction:
The
COVID-19
pandemic,
caused
by
SARS-CoV-2,
has
led
to
an
unprecedented
global
health
crisis.
While
primarily
recognized
for
its
respiratory
implications,
the
virus
shown
a
significant
affinity
nervous
system,
resulting
in
wide
spectrum
of
neurological
manifestations.
This
literature
review
explores
intersection
neurology
and
virology,
focusing
on
acute
long-term
effects
COVID-19.
Methods:
A
comprehensive
current
was
conducted
using
databases
such
as
PubMed,
Scopus,
Web
Science.
Relevant
studies
were
selected
based
their
focus
pathophysiology,
clinical
presentations,
outcomes
Special
attention
given
peer-reviewed
articles,
meta-analyses,
case
reports
published
between
2019
2024.
Results:
identifies
multiple
mechanisms
which
SARS-CoV-2
invades
including
direct
viral
entry
systemic
inflammation.
Acute
manifestations
include
encephalitis,
stroke,
Guillain-Barré
syndrome,
while
sequelae
encompass
cognitive
impairment,
neurodegeneration,
psychiatric
disorders.
findings
underscore
complexity
COVID-19’s
impact
with
both
immediate
enduring
effects.
Conclusion:
Neuro-COVID
represents
evolving
challenge
context
pandemic.
Understanding
implications
is
crucial
improving
patient
guiding
future
research.
underscores
need
heightened
awareness
multidisciplinary
approach
effectively
address
complex
neuro-COVID
spectrum.
Healthcare,
Год журнала:
2023,
Номер
11(11), С. 1593 - 1593
Опубликована: Май 30, 2023
The
COVID-19
sequelae
have
been
shown
to
affect
respiratory
and
cardiological
functions
as
well
neuro-psychological
functions,
and,
in
some
cases,
metabolic/nutritional
aspects.
Italian
National
Institute
for
Insurance
against
Accidents
at
Work
(Istituto
Nazionale
Assicurazione
Infortuni
sul
Lavoro,
INAIL)
recorded
that,
until
December
2022,
315,055
workers
were
affected
by
COVID-19;
therefore,
there
is
a
need
identify
an
effective
approach
treat
such
patients.
Robotic
technological
devices
could
be
integrated
into
the
rehabilitation
programme
of
people
with
long
COVID
conditions.
A
review
literature
showed
that
telerehabilitation
may
improve
functional
capacity,
dyspnoea,
performance,
quality
life
these
patients,
but
no
studies
found
evaluating
effects
robot-mediated
therapy
or
virtual
reality
systems.
Considering
above,
Fondazione
Don
Carlo
Gnocchi
INAIL
propose
multi-axial
sequelae.
To
accomplish
this
goal,
two
institutions
merged
epidemiological
information
gathered
INAIL,
expertise
robotic
Gnocchi,
review.
Our
proposal
aims
facilitate
customized
meet
unique
needs
each
individual,
particular
emphasis
on
utilizing
advanced
technologies
address
current
future
challenges
patient
care.
Frontiers in Psychology,
Год журнала:
2022,
Номер
13
Опубликована: Ноя. 1, 2022
Cognitive
dysfunctions,
both
subjective
and
detectable
at
psychometric
testing,
may
follow
SARS-CoV-2
infection.
However,
the
ecological-functional
relevance
of
such
objective
deficits
is
currently
under-investigated.
This
study
thus
aimed
investigating
association
between
cognitive
measures
physical
cognitive,
outcomes
in
post-COVID-19.Forty-two
COVID-19-recovered
individuals
were
administered
Mini-Mental
State
Examination
(MMSE)
Montreal
Assessment
(MoCA).
The
Functional
Independence
Measure
(FIM)
was
adopted
to
assess
functional-ecological,
motor/physical
(FIM-Motor)
(FIM-Cognitive)
admission
(T0)
discharge
(T1).When
predicting
T0/T1
FIM-total
and-Motor
scores
based
on
MMSE/MoCA
scores,
premorbid
risk
for
decline
(RCD)
disease-related
features,
no
model
yielded
a
significant
fit.
MoCA
-
but
not
MMSE
significantly
predicted
FIM-Cognitive
scores.
related
only
Memory
items.Cognitive
are
associated
with
physical/motor
everyday-life
post-COVID-19
patients.
provide
an
ecological
estimate
functioning
this
population.