Gut microbial metabolic signatures in diabetes mellitus and potential preventive and therapeutic applications DOI Creative Commons
Enriqueta García-Gutiérrez, A. Kate O’Mahony, Reinaldo S. Dos Santos

и другие.

Gut Microbes, Год журнала: 2024, Номер 16(1)

Опубликована: Окт. 18, 2024

Diabetes mellitus can be subdivided into several categories based on origin and clinical characteristics. The most common forms of diabetes are type 1 (T1D), 2 (T2D) gestational (GDM). T1D T2D chronic diseases affecting around 537 million adults worldwide it is projected that these numbers will increase by 12% over the next two decades, while GDM affects up to 30% women during pregnancy, depending diagnosis methods. These have varied origins: an autoimmune disease, commonly associated with, but not limited to, certain lifestyle patterns result a combination genetic predisposition pregnancy factors. Despite some pathogenic differences among diabetes, there markers with their development. For instance, gut barrier impairment inflammation unbalanced microbiota metabolites may factors in development progression. Here, we summarize microbial signatures been linked how they connected diet and, ultimately, impact metabolite profiles resulting from host-gut microbiota-diet interactions. Additionally, recent advances relating promising preventive therapeutic interventions focusing targeted modulation alleviate T1D, GDM.

Язык: Английский

Gut microbial metabolic signatures in diabetes mellitus and potential preventive and therapeutic applications DOI Creative Commons
Enriqueta García-Gutiérrez, A. Kate O’Mahony, Reinaldo S. Dos Santos

и другие.

Gut Microbes, Год журнала: 2024, Номер 16(1)

Опубликована: Окт. 18, 2024

Diabetes mellitus can be subdivided into several categories based on origin and clinical characteristics. The most common forms of diabetes are type 1 (T1D), 2 (T2D) gestational (GDM). T1D T2D chronic diseases affecting around 537 million adults worldwide it is projected that these numbers will increase by 12% over the next two decades, while GDM affects up to 30% women during pregnancy, depending diagnosis methods. These have varied origins: an autoimmune disease, commonly associated with, but not limited to, certain lifestyle patterns result a combination genetic predisposition pregnancy factors. Despite some pathogenic differences among diabetes, there markers with their development. For instance, gut barrier impairment inflammation unbalanced microbiota metabolites may factors in development progression. Here, we summarize microbial signatures been linked how they connected diet and, ultimately, impact metabolite profiles resulting from host-gut microbiota-diet interactions. Additionally, recent advances relating promising preventive therapeutic interventions focusing targeted modulation alleviate T1D, GDM.

Язык: Английский

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