Melatonin as an adjunctive therapy in cardiovascular disease management
Science Progress,
Год журнала:
2024,
Номер
107(4)
Опубликована: Окт. 1, 2024
Melatonin,
N-acetyl-5-methoxytryptamine,
is
a
neuroendocrine
hormone
secreted
by
the
pineal
gland.
This
pleiotropic
indoleamine
possesses
amphiphilic
properties,
allowing
it
to
penetrate
most
biological
barriers
and
exert
its
effects
at
subcellular
level.
Importantly,
melatonin
also
plays
crucial
role
in
regulating
body's
response
circadian
rhythms,
adapting
internal
external
environmental
cues.
Melatonin
functions
as
powerful
antioxidant
free
radical
scavenger,
protecting
cells
from
oxidative
damage.
Its
diverse
physiological
roles
include
maintaining
functional
integrity
of
endothelial
cells,
thereby
preventing
atherosclerosis,
major
contributor
cardiovascular
disease.
Additionally,
exhibits
scavenging
potentially
improving
metabolic
disorders.
These
combined
suggest
unique
adjunctive
therapeutic
potential
for
treating
diseases.
review
aims
explore
mechanisms
which
interacts
with
system
investigates
use
an
agent
managing
Язык: Английский
Response to “Letter to the Editor regarding ‘Parkinson’s Disease: News on the Action of Melatonin’ by Scorza et al”
Sleep Medicine,
Год журнала:
2025,
Номер
130, С. 13 - 14
Опубликована: Март 13, 2025
Язык: Английский
Melatonin Promotes Cerebral Angiogenesis in Ischemic Mice via BMP6/Smad1/5/9 Pathway
Molecular Neurobiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 25, 2025
Angiogenesis
facilitates
the
reinstatement
of
blood
supply
to
cerebral
tissues
after
stroke
by
reconstructing
vascular
network,
thereby
rescuing
penumbra
region
and
restoring
neural
functions.
Melatonin
can
modulate
angiogenesis
under
a
variety
biological
disease-related
states,
bone
morphogenetic
protein
6
(BMP6)
targets
regulators
associated
with
angiogenesis.
The
specific
functions
melatonin
BMP6
in
following
infarction,
along
potential
intrinsic
regulatory
interactions
between
them,
are
currently
unclear
need
further
investigation.
was
given
mice
from
1st
day
through
28th
post
permanent
distal
middle
artery
occlusion
(dMCAO).
Our
research
revealed
that
enhanced
neurological
performance
decreased
size
brain
infarction.
Additionally,
it
boosted
circulation
fostered
area.
Meanwhile,
facilitated
endothelial
cells
migration
tube
formation
oxygen-glucose
deprivation
(OGD).
promoted
expression
its
downstream
targets,
Smad1/5/9,
as
well
factors
Vascular
Endothelial
Growth
Factor
(VEGF)
Angiopoietin-1
(Ang1)
vivo
vitro,
which
counteracted
or
partially
inhibited
suppression
expression.
provides
strong
evidence
promotes
infarction
BMP6/Smad1/5/9
signaling
pathway,
supporting
restoration
function.
Язык: Английский
Human and gut microbiota synergy in a metabolically active superorganism: a cardiovascular perspective
Frontiers in Cardiovascular Medicine,
Год журнала:
2024,
Номер
11
Опубликована: Окт. 11, 2024
Despite
significant
advances
in
diagnosis
and
treatment
over
recent
decades,
cardiovascular
disease
(CVD)
remains
one
of
the
leading
causes
morbidity
mortality
Western
countries.
This
persistent
burden
is
partly
due
to
incomplete
understanding
fundamental
pathogenic
mechanisms,
which
limits
effectiveness
current
therapeutic
interventions.
In
this
context,
evidence
highlights
pivotal
role
immuno-inflammatory
activation
by
gut
microbiome
influencing
disorders,
potentially
opening
new
avenues.
Indeed,
while
atherosclerosis
has
been
established
as
a
chronic
inflammatory
arterial
wall,
accumulating
data
suggest
that
immune
system
regulation
anti-inflammatory
pathways
mediated
microbiota
metabolites
play
crucial
range
CVDs,
including
heart
failure,
pericardial
disease,
arrhythmias,
cardiomyopathies.
Of
particular
interest
emerging
how
tryptophan
metabolism-by
both
host
microbiota-converges
on
Aryl
hydrocarbon
Receptor
(AhR),
key
regulator
homeostasis.
review
seeks
enhance
our
inflammation
CVD,
with
focus
microbiome-derived
metabolites,
such
indoles
their
derivatives,
contribute
cardioimmunopathology.
By
exploring
these
we
aim
facilitate
development
novel,
microbiome-centered
strategies
for
combating
CVD.
Язык: Английский