Obesity Control and Supplementary Nutraceuticals as Cofactors of Brain Plasticity in Multiple Sclerosis Populations DOI Open Access

Lorena Ciumărnean,

Oliviu Florențiu Sârb, Nicu Cătălin Drăghici

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(20), С. 10909 - 10909

Опубликована: Окт. 10, 2024

Multiple sclerosis (MS) is an immune-mediated disease characterized by inflammation, demyelination, and neurodegeneration within the central nervous system. Brain plasticity, brain’s ability to adapt its structure function, plays a crucial role in mitigating MS’s impact. This paper explores potential benefits of lifestyle changes nutraceuticals on brain plasticity MS population. Lifestyle modifications, including physical activity dietary adjustments, can enhance upregulating neurotrophic factors, promoting synaptogenesis, reducing oxidative stress. Nutraceuticals, such as vitamin D, omega-3 fatty acids, antioxidants like alpha lipoic acid, have shown promise supporting health through anti-inflammatory neuroprotective mechanisms. Regular has been linked increased levels brain-derived factor improved cognitive function. Dietary interventions, caloric restriction intake polyphenols, also positively influence plasticity. Integrating these into management provide complementary approach traditional therapies, potentially improving neurological outcomes enhancing quality life for

Язык: Английский

Preparation and Evaluation of Curcumin Derivatives Nanoemulsion Based on Turmeric Extract and Its Antidepressant Effect DOI Creative Commons

Lin Sheng,

Yumeng Wei,

Chao Pi

и другие.

International Journal of Nanomedicine, Год журнала: 2023, Номер Volume 18, С. 7965 - 7983

Опубликована: Дек. 1, 2023

Purpose: The early stage of this study verified that a turmeric extract (TUR) including 59% curcumin (CU), 22% demethoxycurcumin (DMC), and 18% bisdemethoxycurcumin (BDMC), could enhance the stability CU had greater antidepressant potential in vitro. objective was to develop nano-delivery system containing TUR (TUR-NE) improve pharmacokinetic behavior its effect. Methods: explored using ABTS, oxidative stress-induced cell injury, high-throughput screening model. TUR-NE fabricated, optimized characterized. behaviors were evaluated following oral administration normal rats. effect assessed within chronic unpredictable mild stress model (CUMS) mice. behavioral biochemical indexes mice conducted. Results: results depicted 3.18 1.62 times higher antioxidant capacity than ascorbic acid CU, respectively. inhibition on ASP+ transport significantly enhanced compared with fluoxetine CU. displayed particle size 116.0 ± 0.31 nm, polydispersity index value 0.121 0.007, an encapsulation rate 98.45%, good release cold storage. pharmacokinetics indicated AUC (0-t) 8.436 4.495 TUR, while C max 9.012 5.452 pharmacodynamic confirmed superior by improving depressant-like elevating content 5-hydroxytryptamine plasma brain CUMS showed safety repeated administration. Conclusion: TUR-NE, which small uniform size, bioavailability TUR. It be promising novel preparation against depression. Keywords: extract, curcuminoids, nanoemulsion, stability, effect,

Язык: Английский

Процитировано

8
Effect of curcumin supplementation on symptoms of anxiety: A systematic review and meta-analysis of randomized controlled trials DOI

Soroor Fathi,

Soheil Agharloo,

Maryam Falahatzadeh

и другие.

Clinical Nutrition ESPEN, Год журнала: 2024, Номер 62, С. 253 - 259

Опубликована: Июнь 3, 2024

Язык: Английский

Процитировано

2
Cutting the First Turf to Heal Post-SSRI Sexual Dysfunction: A Male Retrospective Cohort Study DOI Creative Commons
Rosaria De Luca, Mirjam Bonanno, Alfredo Manuli

и другие.

Medicines, Год журнала: 2022, Номер 9(9), С. 45 - 45

Опубликована: Сен. 1, 2022

Post-SSRI sexual dysfunction (PSSD) is a set of heterogeneous problems, which may arise during the administration selective serotonin reuptake inhibitors (SSRIs) and persist after their discontinuation. PSSD rare clinical entity, it commonly associated with non-sexual concerns, including emotional cognitive problems poor quality life. To date, however, no effective treatment available. The aim this study was to retrospectively evaluate potential efficacy different treatments used in practice improving male PSSD. Of 30 patients referred our neurobehavioral outpatient clinic from January 2020 December 2021, 13 Caucasian (mean age 29.53 ± 4.57 years), previously treated SSRIs, were included study. Patients major depressive disorder and/or psychotic symptoms excluded priori avoid overlapping symptomatology, potentially reduce misdiagnosis rate. treat PSSD, we decided use drugs positively affecting brain dopamine/serotonin ratio, such as bupropion vortioxetine, well other compounds. This latter drug known not cause or reverse iatrogenic SD. Most patients, vortioxetine nutraceuticals, reported significant improvement all International Index Erectile Function-(IIEF-5) domains (p < 0.05) baseline (T0) 12-month follow-up (T1). Moreover, only patient pelvic muscle vibration reached very positive results. Although data come retrospective open-label small sample size, modulating central nervous system serotonin/dopamine could be improve Large-sample prospective cohort studies randomized trials are needed investigate real prevalence entity confirm promising approach debilitating illness.

Язык: Английский

Процитировано

10
A novel solvent-free co-grinding preparation improves curcumin bioavailability in healthy volunteers: A single-center crossover study DOI Creative Commons
Chenjing Wang, Xin Jiang, Xiaolei Zhang

и другие.

Heliyon, Год журнала: 2023, Номер 9(1), С. e12829 - e12829

Опубликована: Янв. 1, 2023

Curcumin, from the rhizome of turmeric (Curcuma longa L.), has a wide variety biological activities. Unfortunately, its poor water-solubility greatly limits bioavailability. The purpose this study was to evaluate CUMINUP60®, novel preparation utilizing solvent-free, co-grinding method designed improve curcumin's We performed single-center crossover experiment compare new product with standard 95% curcumin in blood plasma twelve healthy adults (10 males, 2 females). Total bioavailability and sulfate glucuronide conjugates test product, measured by their areas under curve over 12 h (AUC0-T), showed combined increase 178-fold reference product. represents significant improvement for providing greater curcumin, as compared several other branded preparations. It therefore broad applications preparing more effective health ingredient functional foods, beverages, nutraceuticals.

Язык: Английский

Процитировано

6
Hawaiian Plants with Beneficial Effects on Sleep, Anxiety, and Mood, etc. DOI Creative Commons

Pornphimon Meesakul,

Tyler Shea,

Shi Xuan Wong

и другие.

Pharmaceuticals, Год журнала: 2023, Номер 16(9), С. 1228 - 1228

Опубликована: Авг. 30, 2023

Diverse chemical messengers are responsible for maintaining homeostasis in the human body, example, hormones and neurotransmitters. Various Hawaiian plant species produce compounds that exert effects on these systems of which they a part. The main purpose this review article is to evaluate potential plants reducing pain anxiety improving sleep mood. A comprehensive literature search was conducted SciFinder, PubMed, Science Direct, Scopus, Google Scholar, Scientific Information Database between 2019 2023 identify related articles. Results indicate several species, such as M. citrifolia P. methysticum, have medicinal properties associated with effects. These been used traditional cultural practices centuries, suggesting their benefit health well-being. This presents analysis available evidence concerning impacts sleep, anxiety, mood, pain.

Язык: Английский

Процитировано

5
Candida die-off: Adverse effect and neutralization with phytotherapy approaches DOI
Neha Jaiswal, Awanish Kumar

Toxicon, Год журнала: 2023, Номер 237, С. 107555 - 107555

Опубликована: Дек. 8, 2023

Язык: Английский

Процитировано

5
Effects of Curcuma longa (turmeric) and curcumin on the premenstrual syndrome and dysmenorrhea: A systematic review DOI

Zahra Shabanian Boroujeni,

Saeid Heidari-Soureshjani, Catherine M.T. Sherwin

и другие.

Journal of Endometriosis and Pelvic Pain Disorders, Год журнала: 2024, Номер 16(1), С. 33 - 44

Опубликована: Янв. 24, 2024

Premenstrual syndrome (PMS) and dysmenorrhea, in addition to harming the physical mental health of women, also disrupt their daily life quality life. We aimed investigate effects underlying mechanisms Curcuma longa (turmeric) curcumin on PMS dysmenorrhea. PRISMA guideline 2020 was followed for conducting this systematic review. Comprehensive literature searches were conducted across multiple databases, including PubMed, EMBASE, Web Science, Scopus. Finally, 17 articles found after considering study’s inclusion exclusion criteria into account. Data extracted entered an Excel file further investigation drew results. affect dysmenorrhea through various mechanisms. They inhibit activity cyclooxygenase-2 (COX-2) production prostaglandins, thus reducing inflammation pain. Additionally, curcumin’s antioxidant properties protect against oxidative stress, lipid peroxidation helps maintain hormonal balance, exert analgesic effects, relieve symptoms insert neurotransmitter modulatory properties, such as increased serotonin dopamine levels, which may contribute antidepressant, sedative effects. indicated promising therapeutic due anti-inflammatory Although, well-designed clinical trials are needed establish efficacy optimal dosage.

Язык: Английский

Процитировано

1
Preparation and Characterization of Small-Size and Strong Antioxidant Nanocarriers to Enhance the Stability and Bioactivity of Curcumin DOI Creative Commons
Shanshan Tie,

Yu-Jin Yang,

Jiawei Ding

и другие.

Foods, Год журнала: 2024, Номер 13(23), С. 3958 - 3958

Опубликована: Дек. 8, 2024

The purpose of this study was to design nanocarriers with small-size and antioxidant properties for the effective encapsulation curcumin. Here, procyanidins, vanillin, amino acids were used successfully prepare a controllable size in range 328~953 nm endow ability based on one-step self-assembly method. reaction involved Mannich phenolic hydroxyl groups aldehyde acids. Subsequently, curcumin nanoparticles prepared by loading nanocarrier, efficiency 85.97%. Compared free curcumin, capacity photothermal stability embedded significantly improved, it could be slowly released into simulated digestive fluid. Moreover, using corticosterone-induced PC12 cell injury model, viability increased 23.77% after intervention nanoparticles, cellular also improved. work can effectively improve solubility, stability, bioactivity which provides reference embedding delivery other hydrophobic bioactive compounds.

Язык: Английский

Процитировано

1
A galantamine–curcumin hybrid lacks the depressant side effect of acetylcholinesterase inhibitors DOI Creative Commons
Ivanka Kostadinova, Mariyana Atanasova, Georgi Stavrakov

и другие.

Biotechnology & Biotechnological Equipment, Год журнала: 2024, Номер 38(1)

Опубликована: Янв. 16, 2024

Acetylcholinesterase inhibitors (AChEIs) are drugs that enhance cholinergic neuro-transmission and used for the treatment of Alzheimer’s disease myasthenia gravis. Common AChEIs include rivastigmine, donepezil galantamine (GAL), but they can cause side effects like nausea, vomiting, depression bradycardia. A potential link exists between increased risk. Recently, we have discovered a hybrid compound (4b) combining GAL curcumin (CCN), which shows improved anticholinesterase activity neuroprotective effects. It could be developed as multitarget agent neurodegenerative disorders. Here, examine compound’s depressant effect on mice, comparing it to CCN. Tests were conducted twice using tail suspension test (TST) forced swim over an 8-day period. The results showed 4b lacked even displayed mild antidepressant similar CCN in TST. This suggests incorporating fragments, CCN, into potentially neutralize their depressive

Язык: Английский

Процитировано

1
Regulation Mechanism and Potential Value of Active Substances in Spices in Alcohol–Liver–Intestine Axis Health DOI Open Access
Jianyu Huang, Tao Huang, Jinjun Li

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(7), С. 3728 - 3728

Опубликована: Март 27, 2024

Excessive alcohol intake will aggravate the health risk between liver and intestine affect multi-directional information exchange of metabolites host cells microbial communities. Because side effects clinical drugs, people tend to explore intervention value natural drugs on diseases. As a flavor substance, spices have been proven medicinal value, but they are still rare in treating hepatointestinal diseases caused by alcohol. This paper summarized metabolic transformation potential various perfume active substances improving It is also found that bioactive can exert antioxidant activity environment reduce oxidative stress These interfere with fatty acid synthesis, promote sugar lipid metabolism, injury steatosis. They effectively regulate balance intestinal flora, production SCFAs, restore microenvironment.

Язык: Английский

Процитировано

1