Case Reports in Psychiatry,
Год журнала:
2022,
Номер
2022, С. 1 - 5
Опубликована: Авг. 3, 2022
Posttraumatic
stress
disorder
(PTSD)
is
a
debilitating
occurring
in
the
context
of
traumatic
event
and
characterized
by
intrusive
avoidance
symptoms,
negative
alterations
cognition
mood,
arousal
reactivity
changes.
Despite
its
representation
throughout
literature,
pathophysiology
PTSD
remains
incompletely
understood,
thus
contributing
to
broad,
variable,
at
times,
experimental
treatment
options.
The
authors
present
first
documented
case
rapid
successful
management
using
valproic
acid
twice
daily
dosing
prazosin
aimed
targeting
symptoms
hyperarousal
both
nightly
flashbacks
nightmares,
respectively.
also
discuss
postulations
underlying
mechanisms
action
responsible
for
such
symptom
alleviation.
Further
investigation
needed
expand
upon
our
knowledge
use
agents
improve
existing
clinical
guidelines,
especially
acute
setting,
providing
better
overall
prognosis.
Turkish Journal of Psychiatry,
Год журнала:
2023,
Номер
unknown
Опубликована: Янв. 1, 2023
Two
major
earthquakes
hit
Turkey
at
the
Kahramanmaraş
region
on
February
6th
2023.
The
affected
almost
15
million
individuals,
resulting
in
more
than
forty
thousand
deaths,
thousands
of
wounded
and
destruction
ancient
cities
humankind.
Immediately
after
earthquakes,
Psychiatric
Association
organized
an
educational
event
to
address
needs
for
a
guidance
how
approach
trauma
such
big
scale.
experts
this
summarized
their
presentations
prepared
review
guide
mental
health
professionals
serving
victims
disaster.
summarizes
early
symptoms
trauma,
puts
framework
principles
psychological
first
aid,
initial
stages
disaster,
planning,
triage,
psychosocial
support
systems
proper
use
medications.
text
covers
evaluation
impact
aligning
psychiatric
practice
with
interventions,
improvement
counseling
skills
methods
better
understand
mind
during
acute
post
phase.
A
set
highlight
challenges
child
psychiatry,
brings
systematic
overview
earthquake
discuss
symptomatology,
aid
intervention
children
adolescents.
Last,
forensic
perspective
is
presented,
followed
by
piece
essentials
delivering
bad
news
concluded
emphasis
burnout,
syndrome
avoid
particularly
field
professionals,
possible
preventive
measures.
Keywords:
Disaster,
support,
stress
disorder,
traumatic
disorder.
Frontiers in Psychiatry,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 6, 2024
Introduction
Post-traumatic
stress
disorder
(PTSD)
is
a
psychiatric
triggered
by
exposure
to
life-threatening
or
sexually
violent
traumatic
event,
and
characterized
symptoms
involving
intrusive
re-experiencing,
persistent
avoidance
of
associated
stimuli,
emotional
cognitive
disturbances,
hyperarousal
for
long
periods
after
the
trauma
has
occurred.
These
debilitating
induce
occupational
social
impairments
that
contribute
significant
clinical
burden
PTSD
patients,
substantial
socioeconomic
costs,
reaching
approximately
$20,000
dollars
per
individual
with
each
year
in
US.
Despite
increased
translational
research
focus
field
PTSD,
development
novel,
effective
pharmacotherapies
its
treatment
remains
an
important
unmet
need.
Observations
In
this
review,
we
summarize
evidence
implicating
dysfunctional
activity
amygdala
pathophysiology
PTSD.
We
identify
transient
receptor
potential
canonical
(TRPC)
ion
channels
as
promising
drug
targets
given
their
distribution
amygdala,
from
animal
studies
demonstrating
role
fear
response
modulation.
discuss
evidence-based
pharmacotherapy
psychotherapy
approaches
Discussion
view
prevalence
economic
further
investigation
warranted
into
novel
based
on
our
knowledge
involvement
brain
circuitry
well
added
value
combined
better
manage
symptoms.
Psychiatria Polska,
Год журнала:
2023,
Номер
57(4), С. 705 - 727
Опубликована: Авг. 31, 2023
Zespół
stresu
pourazowego
(ang.
post-traumatic
stress
disorder,
PTSD)
to
zaburzenie
psychiczne
występujące
po
udziale
w
traumatycznym
wydarzeniu,
takim
jak
doświadczenie
klęski
żywiołowej,
udział
wypadku,
zamach
terrorystyczny
lub
konflikt
zbrojny,
bycie
ofiarą
gwałtu,
tortur
przemocy
fizycznej,
doznanie
urazu
znalezienie
się
innej
sytuacji
niosącej
wysokie
ryzyko
utraty
życia.
Ofiara
traumy
nie
zawsze
musi
być
pozycji
osoby
bezpośrednio
zagrożonej
fizyczną
krzywdą.
Zaburzenie
może
rozwinąć
także
na
skutek
ostrej
reakcji
stres
spowodowanej
udziałem
sytuacji,
której
inny
człowiek
doznaje
cierpienia
tyle
niewyobrażalnego,
że
dalsze
normalne
życie
świadka
staje
niemożliwe.
Chorzy
często
są
przekonani,
bezpowrotnie
utracili
zdolność
wcześniejszej
egzystencji.
W
skali
globalnej
zespół
stanowi
coraz
częściej
rozpoznawane
zaburzenie.
Można
przewidywać,
Europie
związku
z
trwającą
wojną
Ukrainie
oraz
kryzysem
migracyjnym
częstość
występowania
ciężkich
zaburzeń
związanych
ze
stresem
będzie
systematycznie
rosła.
Na
przestrzeni
ostatnich
lat
nastąpił
znaczny
postęp
wiedzy
i
rozwoju
metod
służących
przeciwdziałaniu
PTSD.
Potwierdzone
empirycznie
formy
leczenia
obejmują
oddziaływania
psychoterapeutyczne
farmakoterapeutyczne.
Zaproponowane
rekomendacje
zostały
opracowane
przez
ekspertów
obszaru
psychiatrii,
psychologii
klinicznej,
psychoterapii
medycyny
rodzinnej
celu
przedstawienia
wytycznych
dotyczących
postępowania
terapeutycznego
praktyce
lekarskiej
psychologicznej.
Stanowisko
grupy
roboczej
zostało
zgodnie
wiedzą
opartą
dowodach
(evidence-based
practice)
ramach
trzyetapowego
obejmującego:
przegląd
literatury,
dyskusję
dotyczącą
zagadnienia
wypracowanie
wspólnego
stanowiska
eksperckiego.
Annals of General Psychiatry,
Год журнала:
2024,
Номер
23(1)
Опубликована: Май 30, 2024
Personality
disorders
(PD)
are
described
as
enduring
patterns
of
markedly
deviant
and
pervasive
inner
experiences
behaviors,
with
onset
in
adolescence,
which
lead
to
severe
distress
or
impairment.
Patients
suffering
from
major
depressive
disorder
(MDD)
display
higher
rates
comorbidity
personality
disorders,
often
complicating
the
treatment,
worsening
outcomes.
Borderline
(BPD)
is
most
common
PD
frequently
associated
MDD,
shares
several
features.
The
part
research
agrees
on
fact
that
comorbid
BPD
MDD
patients
quite
doubles
poor
response
treatments.
Moreover,
no
treatment
strategy
stands
out
currently
emerge
more
effective
these
cases,
thus
urging
call
for
need
new
approaches.
Herein,
we
revise
current
literature
BPD,
its
neurobiology
well
recent
strategies
used.
Then,
based
pharmacology,
propose
a
possible
role
trazodone
valuable
tool
approach
BPD-MDD.
Military Medicine,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 30, 2024
ABSTRACT
Introduction
Posttraumatic
nightmares
(PTNs)
are
common
among
service
members
with
a
history
of
combat
or
mission-related
trauma
and
associated
decreased
well-being.
Unfortunately,
beyond
establishing
an
association
between
mental
health
symptoms
PTNs,
the
existing
literature
fails
to
provide
more
comprehensive
understanding
factors
PTNs.
The
effectiveness
current
recommended
treatments
is
frequently
debated,
varying
in
levels
support.
Treatment
PTN
complicated,
given
their
number
difficulties
including
posttraumatic
stress
disorder
(PTSD),
anxiety,
depression.
present
study
sought
better
delineate
these
effort
inform
improve
for
nation’s
members.
Materials
Methods
This
utilized
de-identified
data
collected
during
standard
procedures
interdisciplinary
intensive
outpatient
program
traumatic
brain
injury
and/or
psychological
conditions
(N
=
1,550).
Study
analyses
were
performed
under
Walter
Reed
National
Military
Medical
Center
institutional
review
board-approved
protocol.
Three
cross-sectional
forward
likelihood
ratio
logistic
regressions
predicting
presence
PTNs
conducted
while
controlling
alpha-blocker
prazosin,
as
it
treatment
PTSD-associated
nightmares.
Separate
models
created
(PTSS),
depression,
anxiety
because
multicollinearity
concerns.
Additional
variables
considered
inclusion
(e.g.,
suicide
ideation,
postconcussive
symptoms),
satisfaction
life,
sleep
pain
that
disrupts
sleep,
early
awakenings,
sleepiness),
demographics
sex,
race/ethnicity,
marital
status,
age),
military
characteristics
rank,
branch,
special
operator
time
service).
Results
PTSS
(odds
[OR]:
1.13),
(OR:
1.19),
depression
1.19)
increased
odds
when
prazosin.
Each
final
accounted
significant
amount
variance
presence/absence
PTN.
included
differed
across
models.
model
disrupted
symptoms,
awakenings.
prazosin
use.
difficulty
falling
asleep
within
30
min,
Although
most
status
all
3
These
findings
illustrated
Tables
2
4.
Conclusions
Findings
support
PTSS,
and,
importantly,
suggest
other
may
be
equally
important
Notably,
observed
patients
sleep.
nature
allows
examination
co-occurring
they
would
clinic,
potentially
informing
assessment
strategies;
however,
precludes
consideration
temporal
relationships.
highlight
importance
considering
comorbid
relevant
gain
complete
Future
research
utilizing
longitudinal
methods
needed
temporal/causal
aspects
