Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Май 29, 2024
Adults
with
Down
syndrome
have
a
genetic
form
of
Alzheimer's
disease
(AD)
and
evidence
cerebrovascular
across
the
AD
continuum,
despite
few
systemic
vascular
risk
factors.
The
onset
progression
in
is
highly
age-dependent,
but
it
unknown
at
what
age
emerges
factors
influence
its
severity.
In
Biomarker
Consortium-Down
Syndrome
study
(ABC-DS;
n
=
242;
25-72),
we
estimated
inflection
point
which
MRI-based
white
matter
hyperintensities
(WMH),
enlarged
perivascular
spaces
(PVS),
microbleeds,
infarcts
emerge
relation
to
demographic
data,
factors,
amyloid
tau,
diagnosis.
Enlarged
PVS
appear
develop
early
30s,
while
WMH,
amyloid,
tau
mid
late
30s.
Age-residualized
WMH
were
higher
women,
individuals
dementia,
lower
body
mass
index.
Participants
hypertension
APOE-ε4
had
age-residualized
respectively.
Lifespan
trajectories
demonstrate
dramatic
profile
adults
that
appears
evolve
developmentally
parallel
pathophysiology
approximately
two
decades
prior
dementia
symptoms.
Chemical Communications,
Год журнала:
2024,
Номер
60(11), С. 1372 - 1388
Опубликована: Янв. 1, 2024
We
highlight
recent
advances
in
the
development
of
multifunctional
molecules
designed
to
limit
misfolding
and
aggregation
intrinsically
disordered
biomolecules,
with
a
focus
on
amyloid-beta
peptide
AD
mutant
p53
protein
cancer.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(12), С. 6683 - 6683
Опубликована: Июнь 18, 2024
Antibodies
that
can
selectively
remove
rogue
proteins
in
the
brain
are
an
obvious
choice
to
treat
neurodegenerative
disorders
(NDs),
but
after
decades
of
efforts,
only
two
antibodies
Alzheimer’s
disease
approved,
dozens
testing
phase,
and
one
was
withdrawn,
other
halted,
likely
due
efficacy
issues.
However,
these
outcomes
should
have
been
evident
since
cannot
enter
sufficiently
blood–brain
barrier
(BBB)
protectant.
all
products
be
rejuvenated
by
binding
them
with
transferrin,
preferably
as
smaller
fragments.
This
model
tested
quickly
at
a
low
cost
applied
bapineuzumab,
solanezumab,
crenezumab,
gantenerumab,
aducanumab,
lecanemab,
donanemab,
cinpanemab,
their
paper
demonstrates
conjugating
transferrin
does
not
alter
such
amyloid-β
(Aβ)
α-synuclein.
We
also
present
selection
conjugate
designs
will
allow
cleavage
upon
entering
prevent
exocytosis
while
keeping
fragments
connected
enable
optimal
proteins.
The
identified
readily
returned
patients
lowest
regulatory
delays.
These
engineered
manufactured
recombinant
engineering,
mRNA
technology,
more
affordable
solution
meet
dire
need
effectively.
National Science Review,
Год журнала:
2024,
Номер
11(7)
Опубликована: Июнь 13, 2024
ABSTRACT
Alzheimer's
disease
(AD)
is
a
devastating
neurodegenerative
that
affects
∼50
million
people
globally.
The
accumulation
of
amyloid-β
(Aβ)
plaques,
predominant
pathological
feature
AD,
plays
crucial
role
in
AD
pathogenesis.
In
this
respect,
Aβ
has
been
regarded
as
highly
promising
therapeutic
target
for
treatment.
Polyoxometalates
(POMs)
are
novel
class
metallodrugs
being
developed
modulators
aggregation,
owing
to
their
negative
charge,
polarity,
and
three-dimensional
structure.
Unlike
traditional
discrete
inorganic
complexes,
POMs
contain
tens
hundreds
metal
atoms,
showcasing
remarkable
tunability
diversity
nuclearities,
sizes,
shapes.
easily
adjustable
structurally
variable
nature
allows
favorable
interactions
with
Aβ.
This
mini-review
presents
balanced
overview
recent
progress
using
mitigate
amyloidosis.
Clear
correlations
between
anti-amyloid
activities
structural
features
also
elaborated
detail.
Finally,
we
discuss
the
current
challenges
future
prospects
combating
AD.
Parkinson's
disease
(PD)
is
the
second
most
prevalent
neurodegenerative
disorder
worldwide.
According
to
Braak
hypothesis,
spreads
along
specific
neuroanatomical
pathways.
Studies
indicate
that
fibrillar
alpha-synuclein
(F-αSyn)
can
propagate
from
cell-to-cell
by
following
intercellular
connections,
leading
selective
death
of
certain
cell
groups
like
substantia
nigra
dopaminergic
neurons
and
advancing
pathology.
Internalized
F-αSyn
be
eliminated
lysosomes,
proteasomes,
or
chaperones
before
it
replicates
inside
cell.
Research
has
shown
somehow
escape
endosomes,
proteasomes
replicate
itself.
However,
impact
on
intracellular
levels
during
initial
hours
their
internalization
remains
unknown.
The
present
study
investigates
effect
chaperone
within
first
6
12
h
after
internalization.
Our
findings
showed
h,
Hsc70
Hsp90
were
increased,
while
leads
a
decrease
suppression
numerous
levels.
Exploring
pathological
effects
PD
cells
will
contribute
identifying
more
targets
for
therapeutic
interventions.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Май 29, 2024
Adults
with
Down
syndrome
have
a
genetic
form
of
Alzheimer's
disease
(AD)
and
evidence
cerebrovascular
across
the
AD
continuum,
despite
few
systemic
vascular
risk
factors.
The
onset
progression
in
is
highly
age-dependent,
but
it
unknown
at
what
age
emerges
factors
influence
its
severity.
In
Biomarker
Consortium-Down
Syndrome
study
(ABC-DS;
n
=
242;
25-72),
we
estimated
inflection
point
which
MRI-based
white
matter
hyperintensities
(WMH),
enlarged
perivascular
spaces
(PVS),
microbleeds,
infarcts
emerge
relation
to
demographic
data,
factors,
amyloid
tau,
diagnosis.
Enlarged
PVS
appear
develop
early
30s,
while
WMH,
amyloid,
tau
mid
late
30s.
Age-residualized
WMH
were
higher
women,
individuals
dementia,
lower
body
mass
index.
Participants
hypertension
APOE-ε4
had
age-residualized
respectively.
Lifespan
trajectories
demonstrate
dramatic
profile
adults
that
appears
evolve
developmentally
parallel
pathophysiology
approximately
two
decades
prior
dementia
symptoms.
