Global research trends of immunosenescence and immunotherapy: A bibliometric study

Human Vaccines & Immunotherapeutics, Год журнала: 2025, Номер 21(1)

Опубликована: Фев. 24, 2025

Immunosenescence refers to the gradual decline in immune system function with age, increasing susceptibility infections and cancer elderly. The advent of novel immunotherapies has revolutionized field treatment. However, majority patients exhibit poor re-sponses immunotherapy, immunosenescence likely playing a significant role. In recent years, progress been made understanding interplay between immunotherapy. Our research aims explore prospects development trends immunotherapy using bibliometric analysis. Relevant articles were collected from Web Science Core Collection (WoSCC) (retrieved on July 20, 2024). Primary characteristics analyzed R package "Biblio-metrix," keyword co-occurrence analysis visualization conducted VOSviewer. A total 213 English-language original review spanning 35 years re-trieved for There was surge publications this starting 2017. United States China contributed most articles. Frontiers Immunology productive journal, while University California System highest contributing institution. Besse Benjamin France emerged as influential researcher field. Popular keywords included "nivolumab," "T cells," "dendritic "regulatory T cells." "immunosenescence-associated secretory phenotype" become new hotspot, checkpoint inhibitors remaining central theme domain. is entering phase rapid will continue hold value future research.

Язык: Английский

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Targeting the early life stages of SARS-CoV-2 using a multi-peptide conjugate vaccine

Vaccine, Год журнала: 2025, Номер 54, С. 126989 - 126989

Опубликована: Март 14, 2025

The spike glycoprotein is a key factor in the infection cycle of SARS-CoV-2, as it mediates both receptor recognition and membrane fusion by virus. Therefore, this study, we aimed to design multi-peptide conjugate vaccine against targeting early stages virus's life cycle. We used iBoost technology, which designed induce immune responses low- or non-immunogenic epitopes. selected six peptide sequences, each representing domain protein (i.e., binding (RBM), subdomain 1 (SD1), 2 (SD2), S1/S2, S2' sequences (FP + S2'), heptad repeat (HR1)). Immunization studies mice displayed targeted humoral cellular specific peptides simultaneously, while inducing cross-protection Delta Omicron coronavirus variants. Moreover, vaccinated hamsters challenged with SARS-CoV-2 elicited high antibody levels peptides, induced neutralizing resulted less weight loss compared controls. This highlights potential for improving viral control disease outcomes when utilizing strategy. using technology conjunction our strategy, were able successfully target non-immunodominant regions activating arms adaptive system.

Язык: Английский

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Rational design and synthesis of pyrazole derivatives as potential SARS-CoV-2 Mpro inhibitors: An integrated approach merging combinatorial chemistry, molecular docking, and deep learning

Bioorganic & Medicinal Chemistry, Год журнала: 2025, Номер 120, С. 118095 - 118095

Опубликована: Фев. 4, 2025

Язык: Английский

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Crystal structures of coronaviral main proteases in complex with the non-covalent inhibitor X77

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 276, С. 133706 - 133706

Опубликована: Июль 7, 2024

Язык: Английский

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A review of the scientific literature on experimental toxicity studies of COVID-19 vaccines, with special attention to publications in toxicology journals

Archives of Toxicology, Год журнала: 2024, Номер unknown

Опубликована: Сен. 3, 2024

Abstract Since the reports of first cases COVID-19, in less than 5 years, a huge number documents regarding that disease and coronavirus (SARS-CoV-2), responsible for infection, have been published. The tremendous scientific covers many topics on different issues directly related to COVID-19/SARS-CoV-2. articles—including reviews—reporting adverse/side effects approved COVID-19 vaccines is considerable. A wide range reported humans after vaccination: thrombotic events/thrombocytopenia, myocarditis/pericarditis, cutaneous reactions, immune-mediated effects, psychiatric adverse events, systemic lupus erythematosus, reproductive toxicity, other miscellaneous effects. In contrast, information nonclinical studies conducted assess potential toxicity/adverse laboratory animals, comparatively very scarce. present review was aimed at revising literature animals toxic/adverse vaccines. addition, investigations those specific toxicology journals with highest impact factors examined one by one. results indicate most nonclinical/experimental adverse/toxic and/or candidates showed—in general terms—a good safety profile. Only some animal were certain found. However, rather surprising result has limited available (in databases PubMed Scopus) performed companies largest manufacturers mRNA world. It assumed these conducted. they not published journals, which does allow judgment international community, including toxicologists.

Язык: Английский

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A Low Number of Baselines γδ T Cells Increases the Risk of SARS-CoV-2 Post-Vaccination Infection

Vaccines, Год журнала: 2024, Номер 12(5), С. 553 - 553

Опубликована: Май 18, 2024

Background: The COVID-19 pandemic is the biggest global health problem in last hundred years. efficacy of vaccine to protect against severe disease estimated be 70–95% according studies carried out, although there are aspects immune response that remain unclear. Methods: Humoral and cellular immunity after administration three doses Pfizer–BioNTech Oxford AstraZeneca vaccines SARS-CoV-2 over one year appearance post-vaccination were studied. IgG IgA antibodies, αβ γδ T-cell subsets, their differentiation stages apoptosis analyzed. Results: Anti-SARS-CoV-2 antibodies showed a progressive increase throughout duration study. This was greatest third dose. highest levels observed subjects who had anti-SARS-CoV-2 prior vaccination. There an CD4+ αβ, CD8+ TEM T cells, decrease CD56+ cells. Post-vaccination infection greater than 60%. symptoms very mild related cell deficit, specifically TEMRA TEM, as well lower pre-vaccine levels. Conclusions: results unveil important role cells SARS-CoV-2-vaccine-mediated protection from disease.

Язык: Английский

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Design of the conserved epitope peptide of SARS-CoV-2 spike protein as the broad-spectrum COVID-19 vaccine

Applied Microbiology and Biotechnology, Год журнала: 2024, Номер 108(1)

Опубликована: Окт. 16, 2024

Our previous study has found that monoclonal antibodies targeting a conserved epitope peptide spanning from residues 1144 to 1156 of SARS-CoV-2 spike (S) protein, namely S(1144-1156), can broadly neutralize all the prevalent strains, including wild type, Alpha, Epsilon, Delta, and Gamma variants. In study, S(1144-1156) was conjugated with bovine serum albumin (BSA) formulated Montanide ISA 51 adjuvant for inoculation in BALB/c mice its potential as vaccine candidate. Results showed titers S protein-specific IgGs neutralizing mouse sera against various variants, Omicron sublineages, were largely induced along three doses immunization. The significant release IFN-γ IL-2 also observed by ELISpot assays through stimulating vaccinated splenocytes peptide. Furthermore, vaccination S(1143-1157)- S(1142-1158)-EGFP fusion proteins elicit more than S(1144-1156)-EGFP protein. Interestingly, antisera collected inoculated exhibited better efficacy BA.2.86 JN.1 subvariants BA.1, BA.2, XBB subvariants. Since amino acid sequences are highly among immunogen containing core be designed effective COVID-19 vaccine. KEY POINTS: • Inoculation induce bnAbs stimulated splenocytes. S(1143-1157) S(1142-1158) vaccines nAbs mice.

Язык: Английский

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A Review of the Scientific Literature on Experimental Toxicity Studies of COVID-19 Vaccines, with Special Attention to Publications in Specific Toxicology Journals

Опубликована: Июнь 25, 2024

Since the reports of first cases COVID-19, in less than 5 years a huge number documents regarding that disease and coronavirus (SARS-CoV-2), responsible for infection, have been published. The tremendous scientific covers many topics on different issues directly related to COVID-19/SARS-CoV-2. It includes studies about efficacy vaccines prevent disease. However, only comparatively low nonclinical -conducted experimental animals- focused potential adverse/toxic effects COVID-19 vaccines. present review was aimed at revising literature laboratory animals toxic/adverse In addition, investigations reported those specific toxicology journals with highest impact factors examined one by one. results indicate most nonclinical/experimental and/or candidates showed -in general terms- good safety profile. Only some animal were certain adverse found. rather surprising result has limited available (in databases PubMed Scopus) performed companies largest manufacturers mRNA world [https://www.google.com/search?sca_esv=ba085665fbb45bd4&sca_upv=1&q=Who+is+the+largest+manufacturer+of+vaccines+in+the+world%3F&sa=X&sqi=2&ved=2ahUKEwj6nMbAi-qGAxVLaqQEHTPwDcIQzmd6BAgZEAY]. Why these -assuming, course, they conducted- not published journals, allowing judgment international community, including toxicologists?

Язык: Английский

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Effects of COVID-19 on Heart Failure and Its Risk Factors: A Bidirectional Mendelian Randomization Study

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Авг. 9, 2024

Introduction Previous studies suggest a potential link between COVID-19 and cardiovascular diseases, particularly heart failure (HF), but causal relationships remain unclear. This study uses bidirectional Mendelian randomization (MR) to investigate these associations.Materials methods We selected genome-wide association (GWAS) datasets detailing phenotypes as exposures, while traits associated with HF its risk factors constituted the outcomes. Our primary estimation method involved utilizing inverse-variance weighted technique for it could provide precise by giving more weight less variance. Alongside, we deployed median, MR-Egger, MR-PRESSO global test, Cochran’s Q statistic address biases, detect correct pleiotropy, assess heterogeneity. Furthermore, conducted MR analysis ascertain directional causality.Results Based on analysis, our findings indicate higher likelihood of developing into among hospitalized patients, well an increased propensity development in individuals all patients. presence increases prevalence COVID-19, escalates severity raises hospitalization rate those affected COVID-19. does not directly escalate incidence HF, type 2 diabetes mellitus (T2DM) rates Meanwhile, chronic kidney disease (CKD) contributes patients.Conclusion provides evidence factors. These clinical implications early detection management patients highlight need targeted healthcare resources.

Язык: Английский

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Recommend existing COVID-19 vaccines to reduce serious illness but new vaccines are needed to prevent transmission

Drugs & Therapy Perspectives, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 26, 2024

Язык: Английский

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