Circulating Cell-Free DNA Integrity for Breast and Prostate Cancer: What Is the Landscape for Clinical Management of the Most Common Cancers in Women and Men?
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(3), С. 900 - 900
Опубликована: Янв. 22, 2025
Breast
cancer
(BC)
and
prostate
(PCa)
are
major
health
problems
for
women
men
worldwide.
Although
therapeutic
approaches
have
increased,
the
complexity
associated
with
their
heterogeneity
progression
requires
better
ways
to
monitor
them
over
time.
Cell-free
DNA
integrity
(cfDI)
represents
a
viable
alternative
needle
biopsy
has
potential
be
representative
of
at
all
stages.
In
addition
advantages
liquid
in
terms
cost
reduced
invasiveness,
cfDI
can
used
detect
repetitive
elements
(e.g.,
ALU
LINE1),
which
could
circumvent
problem
mutational
BC
PCa.
this
review,
we
summarise
latest
findings
on
studies
The
results
show
that
improve
early
detection,
metastasis,
recurrence
BC,
while
limited
prevent
its
clinical
value
PCa
from
being
fully
defined.
However,
it
is
expected
further
near
future
will
help
introduce
use
as
another
biomarker
monitoring
patients.
Язык: Английский
Update on Combination Strategies of PARP Inhibitors
Cancer Control,
Год журнала:
2024,
Номер
31
Опубликована: Янв. 1, 2024
The
application
of
PARP
inhibitors
has
revolutionized
cancer
treatment
and
achieved
significant
advancements,
particularly
with
regard
to
tumors
defects
in
genes
involved
homologous
recombination
repair
(HRR)
processes,
such
as
BRCA1
BRCA2.
Despite
the
promising
outcomes
inhibitors,
certain
limitations
challenges
still
exist,
including
acquired
drug
resistance,
severe
side
effects,
limited
therapeutic
benefits
for
patients
without
deficiency
(HRD).
Various
combinations
involving
have
been
developed
overcome
these
limitations.
Among
these,
immune
checkpoint
antiangiogenic
agents,
various
small-molecule
are
well-studied
strategies
that
show
great
potential
optimizing
efficacy
overcoming
resistance
mechanisms,
expanding
target
populations.
However,
efficiency
overlapping
toxicity
combination
cancers
vary
among
studies,
thereby
limiting
their
use.
In
this
review,
we
describe
mechanisms
better
understand
treatments.
Furthermore,
summarized
recent
studies
on
a
range
medications
discussed
clinical
efficacy.
objective
review
is
enhance
comprehensiveness
information
pertaining
topic.
Язык: Английский
Strategic Advances in Combination Therapy for Metastatic Castration-Sensitive Prostate Cancer: Current Insights and Future Perspectives
Cancers,
Год журнала:
2024,
Номер
16(18), С. 3187 - 3187
Опубликована: Сен. 18, 2024
The
contemporary
treatment
for
metastatic
castration-sensitive
prostate
cancer
(mCSPC)
has
evolved
significantly,
building
on
successes
in
managing
castration-resistant
(mCRPC).
Although
androgen
deprivation
therapy
(ADT)
alone
long
been
the
cornerstone
of
mCSPC
treatment,
combination
therapies
have
emerged
as
new
standard
care
based
recent
advances,
offering
improved
survival
outcomes.
Landmark
phase
3
trials
demonstrated
that
adding
chemotherapy
(docetaxel)
and
receptor
pathway
inhibitors
to
ADT
significantly
enhances
overall
survival,
particularly
patients
with
high-volume,
high-risk,
or
de
novo
disease.
Despite
these
advancements,
a
concerning
gap
between
evidence-based
guidelines
real-world
practice
remains,
many
not
receiving
recommended
therapies.
challenge
optimizing
sequences,
considering
both
disease
control
burdens,
identifying
clinical
biological
subgroups
could
benefit
from
personalized
strategies
persists.
advent
triplet
shown
promise
extending
but
uro-oncology
community
must
narrow
evidence
deliver
most
effective
care.
Current
research
is
focused
refining
approaches
utilizing
biomarkers
guide
selection,
aiming
offer
more
adaptive
management.
Thus,
aligning
practices
evolving
urgently
needed
improve
outcomes
facing
this
incurable
Язык: Английский
Innovations and Emerging Trends in Prostate Cancer Management: A Literature Review
Cureus,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 6, 2024
Prostate
cancer
(PC)
is
considered
the
second
most
diagnosed
in
men
worldwide.
It
remains
a
leading
cause
of
cancer-related
death.
Recently,
many
modalities
have
been
discovered
and
used
diagnosis
management
PC,
with
incorporation
treatment
options
such
as
hormonal
therapy,
chemotherapy,
targeted
therapies,
immunotherapy,
precision
medicine.
Robotics
artificial
intelligence
(AI)
further
modified
PCs,
improving
accuracy
disease
progression.
This
comprehensive
review
offers
an
in-depth
exploration
historical
treatments,
evaluation
current
therapeutic
techniques,
discussion
use
robotic
surgery
AI,
examination
ongoing
clinical
trials
emerging
procedures.
Additionally,
this
also
covers
challenges.
By
inspecting
these
aspects,
may
provide
valuable
information
regarding
future
research
practice
directions
PC
treatment,
contributing
to
thorough
understanding
complex
context
management.
Язык: Английский