Potentially inappropriate prescribing in people with dementia: An Australian population‐based study

International Journal of Geriatric Psychiatry, Год журнала: 2019, Номер 34(10), С. 1498 - 1505

Опубликована: Июнь 7, 2019

To investigate the prevalence of potentially inappropriate prescribing (PIP) using Screening Tool Older Person's Prescriptions (STOPP) criteria in people with dementia compared without dementia.A retrospective cohort study was conducted Pharmaceutical Benefits Scheme 10% sample pharmacy claims. People were defined as those dispensed a medicine for (cholinesterase inhibitors, memantine, or risperidone behavioural and psychological symptoms dementia) between 1 January 2005 31 December 2015, aged 65 years older at 2016 alive end 2016. An age- gender-matched comparison not medicines identified. PIP determined 2016.In total, 8280 41 400 comparisons included: 63% female median age 82 years. 79% among 70% group (P < .0001). Use anticholinergics, long-term use high-dose proton pump benzodiazepines most common instances dementia. After adjustments age, gender, comorbidity, number prescribers, more likely to be exposed than (adjusted OR 1.44, 95% CI, 1.35-1.53, P .0001).PIP comparisons. These results highlight need effective interventions optimize

Язык: Английский

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Is Ongoing Anticholinergic Burden Associated With Greater Cognitive Decline and Dementia Severity in Mild to Moderate Alzheimer’s Disease?

The Journals of Gerontology Series A, Год журнала: 2019, Номер 75(5), С. 987 - 994

Опубликована: Окт. 15, 2019

Abstract Background Use of anticholinergic medication is associated with an increased risk cognitive impairment and/or dementia. Despite this, the impact continuing properties in those diagnosed Alzheimer’s Disease (AD) not clear. Methods Analysis data from NILVAD, 18-month randomized controlled trial Nilvadipine AD. Effects ongoing Anticholinergic Cognitive Burden (ACB) on cognition (ADAS-Cog: Cog Subsection) and dementia severity (CDR-sb: Clinical Dementia Rating – Sum Boxes/DAD: Disability Assessment for Dementia) over 18 months was evaluated adjusting important clinical covariates. Results Just one-quarter (27.90%, n = 142/510) patients mild to moderate AD were prescribed a potential/definite anticholinergic. While ACB score greater progression ADAS-Cog/CDR-sb time, higher total predicted DAD, which persisted after robust covariate adjustment (β Coef: −1.53, 95% CI: −2.83 −0.23, p .021). There significant interaction between APOE ε4 status score, carriers experiencing both CDR-Sb 0.36, 0.05–0.67, .021) DAD −3.84, −7.65 0.03, .049). Conclusions Ongoing use but CDR-sb. ε 4 may be particularly vulnerable effect severity, x interactions demonstrated

Язык: Английский

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Deprescribing potentially inappropriate medications in memory clinic patients (DePIMM): A feasibility study

Research in Social and Administrative Pharmacy, Год журнала: 2020, Номер 16(10), С. 1392 - 1397

Опубликована: Янв. 22, 2020

Язык: Английский

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Potentially Inappropriate Medication Among People With Dementia in China: A Nationwide Cross-Sectional Study

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Июнь 13, 2022

Objectives: The purpose of this study was to explore the prevalence potentially inappropriate medication (PIM) among older outpatients (age ≥ 65 years old) with dementia in eight cities China using AGS Beers criteria 2019 and identify potential factor increasing number PIMs. Methods: A cross-sectional about PIM from January 2020 December carried out China, Chengdu, Beijing, Guangzhou, Shanghai, Shenyang, Tianjin, Zhengzhou, Hangzhou, distributing five major geographical regions (east, west, north, south, central). diagnosis based on International Classification Diseases (ICD-10) identify. Based criteria, prescriptions were evaluated. identification factors completed a binary logistic regression model. Results: Of 18,624 dementia, 3.52% detected 1 PIM, 35.91% received at least two antipsychotic drugs quetiapine olanzapine most frequently prescribed patients accounting for 8.01 7.36%, respectively. Logistic analyses showed that female aged >80 who took more medications exposed easily use. Conclusion: use is highly prevalent, associated risk age, sex, medications. by clinicians anpsychotropic drugs, which much frequent than other drugs.

Язык: Английский

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Classifying Polypharmacy According to Pharmacotherapeutic and Clinical Risks in Older Adults: A Latent Class Analysis in Quebec, Canada

Drugs & Aging, Год журнала: 2023, Номер 40(6), С. 573 - 583

Опубликована: Май 6, 2023

Язык: Английский

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