Brain Research Bulletin, Год журнала: 2025, Номер unknown, С. 111237 - 111237
Опубликована: Янв. 1, 2025
Язык: Английский
Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 152, С. 105311 - 105311
Опубликована: Июль 10, 2023
The locus coeruleus (LC) is a small brainstem structure located in the lower pons and main source of noradrenaline (NA) brain. Via its phasic tonic firing, it modulates cognition autonomic functions involved brain's immune response. extent degeneration to LC healthy ageing remains unclear, however, noradrenergic dysfunction may contribute pathogenesis Alzheimer's (AD) Parkinson's disease (PD). Despite their differences progression at later stages, early involvement lead comparable behavioural symptoms such as preclinical sleep problems neuropsychiatric result AD PD pathology. In this review, we draw attention mechanisms that underlie ageing, PD. We aim motivate future research investigate how system play pivotal role which also be relevant other neurodegenerative diseases.
Язык: Английский
Процитировано
12
Behavioral Sciences, Год журнала: 2024, Номер 14(1), С. 43 - 43
Опубликована: Янв. 10, 2024
This systematic review and meta-analysis (PROSPERO CRD42023428105) investigated the effect of dancing on depression anxiety symptoms in older adults. Conducted up to October 2023, search across seven databases gray literature yielded 5020 records. Only randomized trials that analyzed dance interventions for and/or adults were included. Nineteen trials, involving 508 participants classes lasting 5 weeks 18 months, included 16 subjected meta-analysis. Risk bias was assessed using Cochrane tool. The showed a statistically significant reduction among participating (
Язык: Английский
Процитировано
4
International review of neurobiology, Год журнала: 2024, Номер unknown, С. 59 - 97
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
4
Journal of Clinical Medicine, Год журнала: 2024, Номер 13(3), С. 699 - 699
Опубликована: Янв. 25, 2024
Introduction: Depression is the most prevalent comorbid neuropsychiatric condition in individuals with Parkinson’s disease (PD), and its underlying mechanisms are not yet fully understood. Current treatment methods characterised by moderate effectiveness possible side effects, prompting search for new non-invasive safe methods. Methods: This narrative review explores use of transcranial direct current stimulation (tDCS) depression PD, based on neuropsychological measures. Searches were conducted PubMed/Medline, Research Gate, Cochrane databases. Results: Nine relevant studies identified, where scores served as either primary or secondary outcomes. Stimulation protocols displayed heterogeneity, especially concerning choice site. Patient samples also heterogeneous. The majority incorporated anodal targeting left dorsolateral prefrontal cortex (DLPFC). results revealed a reduction among PD patients following tDCS. Potential through which tDCS may alleviate discussed recommendations future research made. Conclusions: Preliminary evidence suggests that applied anodally to DLPFC reduces people PD; however, due heterogeneity analysed, this field should be approached caution warrants further validation confirmation.
Язык: Английский
Процитировано
4
Frontiers in Aging Neuroscience, Год журнала: 2024, Номер 16
Опубликована: Апрель 26, 2024
Objective The non-motor symptoms of Parkinson’s disease (PD) are an important part PD. In recent years, more and non-drug interventions have been applied to alleviate the PD, but relevant evidence is limited. This systematic review meta-analysis was designed evaluate efficacy in patients with Methods Seven databases, including Pubmed, Embease, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang database (WANFANG), VIP (VIP), Biomedical Literature Service System (CBM) were searched from establishment December 2023. Non-drug such as acupuncture, cognitive behavioral therapy (CBT), exercise, repetitive transcranial magnetic stimulation (rTMS), selected search words, two independent evaluators evaluated included literature’s bias risk data extraction. therapeutic by Disease Sleep Scale (PDSS), Hamilton Depression (HAMD), Beck Inventory (BDI), Anxiety (HAMA), Montreal Cognitive Assessment (MoCA), Minimum Mental State Examination (MMSE), Questionnaire-39 (PDQ-39). RevMan 5.4.1 (Reviewer Manager Software 5.4.1). Collaboration, Oxford, United Kingdom analyzed estimated average effect 95% confidence interval (CI). A heterogeneity test used assess differences different treatments. Results We 36 4,027 articles participate this meta-analysis, involving 2,158 participants. Our combined results show that: PDSS: [mean difference (MD) = −19.35, CI (−30.4 −8.28), p < 0.0006]; HAMD: [MD −2.98, (−4.29 −1.67), 0.00001]; BDI: −2.69, (−4.24 4.80), 0.006]; HAMA: -2.00, (−2.83 −1.17), MMSE: 1.20, (0.71 1.68), CoMA: 2.10, (−0.97 3.23), 0.0003]; PDQ-39: −4.03, (−5.96 −1.57), 0.00001]. Conclusion four measures our showed significant improvements sleep, depression, anxiety, cognition, constipation, quality life compared control group, no serious adverse events reported research evidence, we found that there some among subgroups intervention methods, due less literature subgroup, comparison indirect. So, should interpret these carefully. Systematic registration www.crd.york.ac.uk/PROSPERO , identifier CRD42023486897.
Язык: Английский
Процитировано
4
Journal of Hazardous Materials, Год журнала: 2024, Номер 472, С. 134559 - 134559
Опубликована: Май 9, 2024
Язык: Английский
Процитировано
4
Neural Regeneration Research, Год журнала: 2024, Номер 20(6), С. 1628 - 1643
Опубликована: Июнь 3, 2024
The globus pallidus plays a pivotal role in the basal ganglia circuit. Parkinson's disease is characterized by degeneration of dopamine-producing cells substantia nigra, which leads to dopamine deficiency brain that subsequently manifests as various motor and non-motor symptoms. This review aims summarize involvement both manifestations disease. firing activities parvalbumin neurons medial pallidus, including rate pattern, exhibit strong correlations with bradykinesia rigidity associated Increased beta oscillations, are highly correlated rigidity, regulated lateral pallidus. Furthermore, strongly linked loss dopaminergic projections within cortical-basal ganglia-thalamocortical loop. Resting tremors attributed transmission pathological signals from through cortex cerebellum-ventral intermediate nucleus cortico-striato-pallidal loop responsible for mediating pallidi-associated sleep disorders. Medication deep stimulation primary therapeutic strategies addressing treatment symptoms early stages disease, while has been clinically proven be effective alleviating patients advanced particularly movement disorders caused levodopa. Deep targeting internus can improve function tremor-dominant non-tremor-dominant externus alter temporal pattern neural activity throughout ganglia-thalamus network. Therefore, composition neurons, neurotransmitters act on them, their electrical activity, circuits they form guide search new multi-target drugs treat clinical practice. Examining potential intra-nuclear circuit mechanisms facilitate management minimizing side effects stimulation.
Язык: Английский
Процитировано
4
Spanish Journal of Psychiatry and Mental Health, Год журнала: 2024, Номер unknown
Опубликована: Июль 1, 2024
Neuropsychiatric and neurodegenerative disorders are frequently associated with gastrointestinal (GI) co-pathologies. Although the central enteric nervous systems (CNS ENS, respectively) have been studied separately, there is increasing interest in factors that may contribute to conditions affecting both systems. There compelling evidence serotonin (5-HT) play an important role several gut–brain disorders. It well known 5-HT essential for development functioning of CNS. However, most body's produced GI tract. A deeper understanding specific effects on provide basis new therapeutic targets. This review summarizes current data focusing ENS motility, particular emphasis novel aspects signaling where CNS comorbidities common, such as Parkinson's disease depressive
Язык: Английский
Процитировано
4
Frontiers in Neurology, Год журнала: 2023, Номер 14
Опубликована: Май 17, 2023
Introduction Post-stroke depressive symptoms (PSDS) are common and relevant for patient outcome, but their complex pathophysiology is ill understood. It likely involves social, psychological biological factors. Lesion location a readily available information in stroke patients, it unclear if the neurobiological substrates of PSDS spatially localized. Building on previous analyses, we sought to determine associated with specific lesion locations, structural disconnection and/or localized functional diaschisis. Methods In prospective observational study, examined 270 patients first-ever Hospital Anxiety Depression Scale (HADS) around 6 months post-stroke. Based individual locations depression subscale HADS performed support vector regression lesion-symptom mapping, structural-disconnection-symptom mapping network-symptom-mapping, reanalysis this previously published cohort infer structure–function relationships. Results We found that were (i) lesions right insula, putamen, inferior frontal gyrus amygdala (ii) temporal lobe. contrast, no association addition, unable confirm described between symptom load network damage score derived from maps. Discussion our results, other recent studies, see growing evidence prominent role frontostriatal brain circuits PSDS.
Язык: Английский
Процитировано
10
Brain Sciences, Год журнала: 2025, Номер 15(1), С. 41 - 41
Опубликована: Янв. 3, 2025
Background: Parkinson's disease (PD) is a neurodegenerative disorder marked by motor deficits and non-motor symptoms, such as depression, which are associated with dopaminergic loss α-synuclein aggregation in the brain. Objectives: This study investigated neuroprotective effects of hydroalcoholic extract purple fruit Eugenia uniflora (PFEU) on ability depressive-like behaviors PD model induced 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) female Wistar rats. Methods: Rats received intranasal administration MPTP or vehicle, followed 14 days oral PFEU (300 2000 mg/kg, administered once daily) vehicle. Depressive-like behavior was assessed using splash forced swimming tests, while evaluated rotarod open field tests. On day 15, hippocampal tissue collected for immunoreactivity analysis. Results: treatment behavior, significantly reversed PFEU, evidenced increased grooming decreased immobility. No coordination locomotion were observed. Furthermore, prevented MPTP-induced increase α-synuclein, p-p53, Bax restoring Bcl-2 levels, suggesting through modulation apoptotic pathways α-synuclein. Conclusions: These findings support PFEU's potential agent rats, highlighting its molecular mechanisms.
Язык: Английский
Процитировано
0