Assessing causal associations of bile acids with obesity indicators: A Mendelian randomization study DOI Creative Commons

Huang Chun-xia,

Shuling Xu,

Rumeng Chen

и другие.

Medicine, Год журнала: 2024, Номер 103(25), С. e38610 - e38610

Опубликована: Июнь 21, 2024

Maintaining a balanced bile acids (BAs) metabolism is essential for lipid and cholesterol metabolism, as well fat intake absorption. The development of obesity may be intricately linked to BAs their conjugated compounds. Our study aims assess how influence the indicators by Mendelian randomization (MR) analysis. Instrumental variables 5 were obtained from public genome-wide association databases, 8 studies related used outcomes. Causal inference analysis utilized inverse-variance weighted (IVW), median, MR-Egger methods. Sensitivity involved MR-PRESSO leave-one-out techniques detect pleiotropy outliers. Horizontal heterogeneity assessed using intercept Cochran Q statistic, respectively. IVW revealed an odds ratio 0.94 (95% confidence interval: 0.88, 1.00; P = .05) between glycolithocholate (GLCA) obesity, indicating marginal negative causal association. Consistent direction estimates median methods was observed in GLCA obesity. Furthermore, demonstrated suggestive trunk percentage, with beta value -0.014 -0.027, -0.0004; .04). findings suggest potential relationship both although no survived corrections multiple comparisons. These results indicate trend towards possible emphasizing need future studies.

Язык: Английский

Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review DOI Creative Commons

Chun‐wei Li,

Kang Yu, Ng Shyh‐Chang

и другие.

Journal of Cachexia Sarcopenia and Muscle, Год журнала: 2022, Номер 13(2), С. 781 - 794

Опубликована: Фев. 2, 2022

Age-associated obesity and muscle atrophy (sarcopenia) are intimately connected reciprocally regulated by adipose tissue skeletal dysfunction. During ageing, inflammation leads to the redistribution of fat intra-abdominal area (visceral fat) fatty infiltrations in muscles, resulting decreased overall strength functionality. Lipids their derivatives accumulate both within between cells, inducing mitochondrial dysfunction, disturbing β-oxidation acids, enhancing reactive oxygen species (ROS) production, leading lipotoxicity insulin resistance, as well enhanced secretion some pro-inflammatory cytokines. In turn, these muscle-secreted cytokines may exacerbate atrophy, support chronic low-grade inflammation, establish a vicious cycle local hyperlipidaemia, that spreads systemically, thus promoting development sarcopenic (SO). We call this metabaging cycle. Patients with SO show an increased risk systemic associated diseases, subsequent progression full-blown sarcopenia even cachexia. Meanwhile many cardiometabolic ostensibly protective effect extremely elderly subjects, also known 'obesity paradox', could possibly be explained our theory subjects normal body mass index might actually harbour various degrees, before it progresses severe sarcopenia. Our review outlines current knowledge concerning possible chain causation obesity, proposes solution paradox, role ageing.

Язык: Английский

Процитировано

335
Multifactorial Mechanism of Sarcopenia and Sarcopenic Obesity. Role of Physical Exercise, Microbiota and Myokines DOI Creative Commons
Jan Bilski, Piotr Pierzchalski, Marian Szczepanik

и другие.

Cells, Год журнала: 2022, Номер 11(1), С. 160 - 160

Опубликована: Янв. 4, 2022

Obesity and ageing place a tremendous strain on the global healthcare system. Age-related sarcopenia is characterized by decreased muscular strength, muscle quantity, quality, functional performance. Sarcopenic obesity (SO) condition that combines has substantial influence older adults’ health. Because of complicated pathophysiology, there are disagreements challenges in identifying diagnosing SO. Recently, it become clear dysbiosis may play role onset progression Skeletal secretes myokines during contraction, which an important controlling growth, function, metabolic balance. Myokine dysfunction can cause aggravate obesity, sarcopenia, The only ways to prevent slow particularly sarcopenic physical activity correct nutritional support. While exercise cannot completely age-related loss certainly delay development down rate sarcopenia. purpose this review was discuss potential pathways deterioration obese individuals. We also want present current understanding various factors, including microbiota myokines, process

Язык: Английский

Процитировано

147
The role of obesity and adipose tissue dysfunction in osteoarthritis pain DOI
Marie Binvignat, Jérémie Sellam, Françis Berenbaum

и другие.

Nature Reviews Rheumatology, Год журнала: 2024, Номер 20(9), С. 565 - 584

Опубликована: Авг. 7, 2024

Язык: Английский

Процитировано

27
Autophagy in aging-related diseases and cancer: Principles, regulatory mechanisms and therapeutic potential DOI
Na Wu, Wenhui Zheng,

Yundong Zhou

и другие.

Ageing Research Reviews, Год журнала: 2024, Номер 100, С. 102428 - 102428

Опубликована: Июль 20, 2024

Язык: Английский

Процитировано

24
Relationship between three body obesity indicators, WWI, BMI, WtHR, and periodontitis DOI Creative Commons

XingJin Chen,

ChongWen Zeng,

X. Chen

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 3, 2025

Язык: Английский

Процитировано

4
Effect of MIND diet intervention on cognitive performance and brain structure in healthy obese women: a randomized controlled trial DOI Creative Commons
Golnaz Arjmand, Mojtaba Abbaszadeh, Mohammad Eftekhari

и другие.

Scientific Reports, Год журнала: 2022, Номер 12(1)

Опубликована: Фев. 21, 2022

Previous studies suggested adherence to recently developed Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) associated with cognitive performance. This study aimed examine the effect of MIND dietary pattern on performance features and changes in brain structure healthy obese women. As a total 50 women were assessed eligibility, we randomly allocated 40 participants mean BMI 32 ± 4.31 kg/m2 age 48 5.38 years either calorie-restricted modified diet or standard control diet. Change was primary outcome measured comprehensive neuropsychological test battery. We also performed voxel-based morphometry as secondary quantify differences structure. All measurements administered at baseline 3 months follow-up. Thirty-seven (MIND group = 22 15) completed study. The results found working memory + 1.37 (95% CI 0.79, 1.95), verbal recognition 4.85 3.30, 6.40), attention 3.75 2.43, 5.07) improved more compared (ps < 0.05). Results MRI consist an increase surface area inferior frontal gyrus group. Furthermore, showed decrease cerebellum-white matter cerebellum-cortex two groups Still, greater than findings declare first time that intervention can reverse destructive effects obesity cognition structure, which could be strengthened by modest calorie restriction.Clinical trial registration ClinicalTrials.gov ID: NCT04383704 (First date: 05/05/2020).

Язык: Английский

Процитировано

63
The obesity paradox is mostly driven by decreased noncardiovascular disease mortality in the oldest old in China: a 20-year prospective cohort study DOI
Yuebin Lv, Chen Mao, Xiang Gao

и другие.

Nature Aging, Год журнала: 2022, Номер 2(5), С. 389 - 396

Опубликована: Апрель 25, 2022

Язык: Английский

Процитировано

62
Obesity as a premature aging phenotype — implications for sarcopenic obesity DOI Creative Commons

Emily Nunan,

Carson L. Wright,

Oluwayemisi A. Semola

и другие.

GeroScience, Год журнала: 2022, Номер 44(3), С. 1393 - 1405

Опубликована: Апрель 26, 2022

Obesity and aging have both seen dramatic increases in prevalence throughout society. This review seeks to highlight common pathologies that present with obesity, along the underlying risk factors, remarkable similarity what is observed aged. These include skeletal muscle dysfunction (loss of quantity quality), significant adiposity, systemic alterations autonomic dysfunction, reduction nitric oxide bioavailability, oxidant stress inflammation, dysregulation glucose homeostasis, mitochondrial dysfunction. organized by aforementioned indices succinctly highlights literature demonstrates similarities between aged obese phenotypes human animal models. As an inevitability obesity unlikely significantly decrease near future, these two will ultimately combine as a multidimensional syndrome (a pathology termed sarcopenic obesity). Whether pre-mature accompanying are additive or synergistic upon entering not yet well defined, but goal this illustrate potential consequences double phenotype obesity. Clinically, modifiable factors could be targeted specifically allow for increased health span populations.

Язык: Английский

Процитировано

52
Obesity, obesities and gastrointestinal cancers DOI

Yuntao Zou,

C. S. Pitchumoni

Disease-a-Month, Год журнала: 2023, Номер 69(12), С. 101592 - 101592

Опубликована: Июнь 10, 2023

Язык: Английский

Процитировано

24
Predicted visceral adiposity index in relation to risk of coronary heart disease and all-cause mortality: insights from NHANES DOI Creative Commons

Yixing Luo,

Xiangpeng Zhan, Yang Liu

и другие.

Frontiers in Endocrinology, Год журнала: 2024, Номер 14

Опубликована: Янв. 8, 2024

The Visceral Adiposity Index (VAI) is a straightforward and gender-specific marker that combines anthropometric measurements with lipid profiles. objective of this study was to evaluate the relationship between VAI coronary heart disease (CHD).

Язык: Английский

Процитировано

11