Assessing the human health risks of perfluorooctane sulfonate by in vivo and in vitro studies

Environment International, Год журнала: 2019, Номер 126, С. 598 - 610

Опубликована: Март 8, 2019

The wide use of perfluorooctane sulfonate (PFOS) has led to increasing concern about its human health risks over the past decade. In vivo and in vitro studies are important effective means ascertain toxic effects PFOS on humans mechanisms. This article systematically reviews based currently known facts found by from 2008 2018. Exposure caused hepatotoxicity, neurotoxicity, reproductive toxicity, immunotoxicity, thyroid disruption, cardiovascular pulmonary renal toxicity laboratory animals many systems. These results related epidemiological confirmed PFOS, especially for exposure via food drinking water. Oxidative stress physiological process disruption fatty acid similarity were widely studied mechanisms toxicity. Future research assessing is recommended chronic molecular mechanisms, application various omics, integration toxicological data.

Язык: Английский

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A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior

Frontiers in Toxicology, Год журнала: 2022, Номер 4

Опубликована: Апрель 11, 2022

Per- and polyfluoroalkyl substances (PFAS) are a class of structurally diverse synthetic organic chemicals that chemically stable, resistant to degradation, persistent in terrestrial aquatic environments. Widespread use PFAS industrial processing manufacturing over the last 70 years has led global contamination built natural The brain is lipid rich highly vascularized organ composed long-lived neurons glial cells especially vulnerable impacts lipophilic toxicants. Generally, partition protein-rich tissues body, primarily liver blood, but also detected brains humans, wildlife, laboratory animals. Here we review factors impacting absorption, distribution, accumulation brain, currently available evidence for neurotoxic defined by disruption neurochemical, neurophysiological, behavioral endpoints. Emphasis placed on potential exposures during critical periods development sensitive populations, may exacerbate neurotoxicity PFAS. While limitations inconsistencies across studies exist, body suggests neurobehavioral long-chain more pronounced than resulting from exposure adulthood. There paucity experimental evaluating molecular mechanisms short-chain PFAS, even greater data gaps analysis outside perfluoroalkyl acids. Whereas most were focused acute subchronic high dose single congener, realistic humans wildlife mixtures relatively chronic low nature. Our evaluation human epidemiological, experimental, indicates heightened acids after environmental exposure, comparison studies. These findings highlight need additional neurodevelopmental environmentally relevant concentrations complex

Язык: Английский

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Reproductive and Developmental Toxicology

Patty's Toxicology, Год журнала: 2023, Номер unknown, С. 1 - 46

Опубликована: Июнь 28, 2023

Abstract This chapter provides a practical overview of reproductive and developmental toxicology, with focus on considerations for human health risk assessment. It brief normal reproduction development, as well examples how toxic agents may impact these processes. Default assumptions assessment toxicants are discussed, the types endpoints typically evaluated in animal toxicology studies epidemiology summarized. A is also provided other data that can be useful hazard identification toxicants, including mechanistic new approach methodologies, pharmacokinetics/pharmacodynamics, mixtures. Testing procedures guidelines (including pharmaceuticals industrial or environmental chemicals)

Язык: Английский

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Assessing the contribution of the chemical exposome to neurodegenerative disease

Nature Neuroscience, Год журнала: 2024, Номер 27(5), С. 812 - 821

Опубликована: Апрель 29, 2024

Язык: Английский

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Neurotoxicity of e-cigarettes

Food and Chemical Toxicology, Год журнала: 2020, Номер 138, С. 111245 - 111245

Опубликована: Март 9, 2020

Язык: Английский

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The Link between Obesity, Microbiota Dysbiosis, and Neurodegenerative Pathogenesis

Diseases, Год журнала: 2021, Номер 9(3), С. 45 - 45

Опубликована: Июнь 23, 2021

Current research in medicine several parts of the world has attempted to establish a link between occurrence neurodegenerative pathologies, microbiota dysbiosis, and incidence obesity. The body’s response different physicochemical factors also been influenced by proper assimilation bioactive compounds contained food that is ingested. Oxidative stress one major directly affects functioning human microbiota. reaction this imbalance crucial progression inflammatory processes, which are based on molecular mechanisms. Microbial dysbiosis can result possibly permanent alteration physiological response. This review aims highlight recent contributions made alleviating degenerative diseases, especially for pathologies rising prevalence We discuss significance both modulation possible alleviations modulatory function. argue pre- probiotics (including phenolic stimulating favorable strain from microbiota) an effective alternative support pattern’s over time attenuation indirect causes determine dysbiosis. Molecular aspects presented modulating role following use probiotics.

Язык: Английский

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Air pollution and endocrine disruptors induce human microbiome imbalances: A systematic review of recent evidence and possible biological mechanisms

The Science of The Total Environment, Год журнала: 2021, Номер 816, С. 151654 - 151654

Опубликована: Ноя. 14, 2021

A rich body of literature indicates that environmental factors interact with the human microbiome and influence its composition functions contributing to pathogenesis diseases in distal sites body. This systematic review examines scientific evidence on effect toxicants, air pollutants endocrine disruptors (EDCs), compositional diversity microbiota. Articles from PubMed, Embase, WoS Google Scholar where included if they focused populations or SHIME® model, assessed effects EDCs microbiome. Non-human studies, not written English displaying original research were excluded. The Newcastle-Ottawa Scale was used assess quality individual studies. Results extracted presented tables. 31 studies selected, including 24 related pollutants, 5 EDCs, 2 EDC using model. 19 focussed respiratory system (19), gut (8), skin (2), vaginal (1) mammary microbiomes. No sufficient number are available observe a consistent trend for most microbiota, except streptococcus veillionellales which 9 out 10, 3 4 suggest an increase abundance exposure pollution. limitation reviewed is scarcity existing assessing microbiomes systems. Growing suggests contaminants could change resident e.g. upper lower respiratory, gastrointestinal, female reproductive system. Microbial dysbiosis might lead colonization pathogens outgrowth pathobionts facilitating infectious diseases. It also prime metabolic dysfunctions disrupting production beneficial metabolites. Further should elucidate role development dysregulation microbiota-related immunological processes.

Язык: Английский

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Phthalate toxicity mechanisms: An update

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Год журнала: 2022, Номер 263, С. 109498 - 109498

Опубликована: Окт. 28, 2022

Язык: Английский

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Oxidative Stress as a Common Key Event in Developmental Neurotoxicity

Oxidative Medicine and Cellular Longevity, Год журнала: 2021, Номер 2021(1)

Опубликована: Янв. 1, 2021

The developing brain is extremely sensitive to many chemicals. Perinatal exposure neurotoxicants has been implicated in several neurodevelopmental disorders, including autism spectrum disorder, attention‐deficit hyperactive and schizophrenia. Studies of the molecular cellular events related developmental neurotoxicity have identified a number “adverse outcome pathways,” which share oxidative stress as key event. Oxidative occurs when balance between production free oxygen radicals activity antioxidant system dysregulated. In this review, we describe some neurotoxins that target mechanisms by they elicit stress, phosphorylation mitochondria plasma membrane redox rodent models. We also discuss future directions for identifying adverse pathways neurotoxicity, with goal improving our ability quickly accurately screen chemicals their potential neurotoxicity.

Язык: Английский

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Multiple neurological effects associated with exposure to organophosphorus pesticides in man

Toxicology, Год журнала: 2022, Номер 484, С. 153407 - 153407

Опубликована: Дек. 18, 2022

Язык: Английский

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