Cancers,
Год журнала:
2022,
Номер
14(17), С. 4338 - 4338
Опубликована: Сен. 5, 2022
The
COVID-19
pandemic
has
changed
healthcare
systems
around
the
world.
Medical
personnel
concentrated
on
infectious
disease
management
and
treatments
for
non-emergency
diseases
scheduled
surgeries
were
delayed.
We
aimed
to
investigate
change
in
severity
of
thyroid
cancer
before
after
outbreak
Korea.
collected
three
years
data
(2019,
2020,
2021)
patients
who
received
surgery
a
university
hospital
South
Korea
grouped
them
as
"Before
COVID-19",
"After
1-year"
2-years".
total
number
annual
outpatients
declined
significantly
both
new
(1303,
939,
1098
patients)
follow-up
(5584,
4609,
4739
patients).
Clinical
characteristics,
including
age,
sex,
BMI,
preoperative
cytology
results,
surgical
extent,
final
pathologic
diagnosis,
not
COVID-19.
However,
days
from
first
visit
was
increased
(38.3
±
32.2,
58.3
105.2,
47.8
124.7
days,
p
=
0.027).
Papillary
carcinoma
(PTC)
showed
proportions
extrathyroidal
extension,
lymphatic
invasion,
vascular
cervical
lymph
node
metastasis.
Increased
tumor
size
observed
with
follicular
(3.5
2.2,
4.0
1.9,
4.3
2.3
cm,
0.019).
After
outbreak,
poor
prognostic
factors
increased,
an
increase
tumors
observed.
Due
our
study
being
confined
single
tertiary
institution
Incheon
city,
Korea,
nationwide
studies
that
include
primary
clinics
should
be
required
identify
actual
impact
treatment.
Frontiers in Endocrinology,
Год журнала:
2023,
Номер
13
Опубликована: Март 9, 2023
COVID-19
often
results
in
generalized
inflammation
and
affects
various
organs
systems.
Endocrine
research
focused
on
the
possible
sequelae
of
COVID-19,
with
special
interest
given
to
thyroid
gland.
Clinical
problems
such
as
function
non-thyroidal
illness
(NTI),
autoimmune
thyroiditis,
COVID-19-related
subacute
thyroiditis
(SAT)
quickly
gained
wide
coverage.
Thyrotoxicosis
origins
leads
release
peripheral
hormones
thyroglobulin
(TG),
main
glycoprotein
contained
within
follicular
lumen.
In
our
study,
we
evaluated
TG
levels
COVID-19-positive
patients
investigated
relationships
between
TG,
tests
(TFTs),
inflammatory
markers.
Our
approach
included
separate
subanalyses
who
received
those
did
not
receive
glucocorticoids
(GCs).
entire
population
studied,
concentration
tended
decrease
time
(p<0.001;
p1,2
=
0.025,
p1,3
0.001,
p2,3
0.003),
this
pattern
was
especially
clear
among
treated
GCs
p1,2=<0.001;
p1,3=<0.001;
p
2,3=<0.001).
The
differed
significantly
GC
at
second
third
points
observation
(p=0.033
p=0.001,
consecutively).
differ
normal
abnormal
TFTs.
correlations
TFTs,
markers
were
very
limited.
19
had
elevated
levels,
but
a
TFT
suggestive
thyrotoxicosis
common
group.
There
no
statistically
significant
differences
met
meet
predefined
combined
primary
endpoint.
Subacute
thyroiditis
(SAT)
is
a
self-limiting
inflammatory
condition
of
the
thyroid
gland
with
distinct
symptoms
and
predictable
outcome.
During
current
COVID-19
pandemic,
there
have
been
multiple
isolated
reports
SAT
either
during
active
viral
illness
or
following
recovery.
Here,
we
report
two
such
cases
infection
presenting
SAT.
A
65-year-old
male
presented
two-week
history
anterior
neck
pain,
odynophagia,
high-grade
fever
(38.9°C),
sweating,
palpitations,
tremulousness.
At
physical
examination,
patient
slightly
increased
heart
rate
tender
enlarged
on
palpation.
Laboratory
examination
showed
high
C-reactive
protein
levels,
elevated
erythrocyte
sedimentation
rate,
function
tests
were
suggestive
thyrotoxicosis.
Ultrasonography
heterogeneous
ill-defined
hypoechoic
areas,
scintigraphy
reduced
uptake,
confirming
diagnosis
In
another
case,
52-year-old
fever,
cough,
myalgias,
was
diagnosed
mild
pneumonia,
managed
conservatively.
After
weeks,
had
recurrence
tremors.
Examination
revealed
tachycardia,
hyperhidrosis,
Thyroid
low
thyroid-stimulating
hormone,
normal
total
T4
T3.
bilateral
areas.
our
systematic
review,
including
103
cases,
it
has
suggested
that
should
be
recognized
as
an
uncommon
extra-pulmonary
clinical
manifestation
clinicians
need
to
aware
association.
Pending
larger
multicentric
studies,
management
case-by-case
basis.
Frontiers in Medicine,
Год журнала:
2024,
Номер
11
Опубликована: Фев. 7, 2024
Background
SARS-CoV-2
could
trigger
multiple
immune
responses,
leading
to
several
autoimmune
diseases,
including
thyroid
diseases.
Many
cases
of
diseases
caused
by
COVID-19
infection
have
been
reported.
Here,
we
describe
the
disease
development
patients
with
after
infection.
Methods
The
clinical
characteristics,
diagnosis
and
treatment
five
different
were
Results
Female
primary
which
stable
for
many
years
One
month
infection,
has
undergone
evolution.
Case
1,
a
patient
history
long-term
Hashimoto’s
thyroiditis,
suddenly
suffered
from
Graves
2,
thyroiditis
nodules,
3,
disease,
worsening
above
three
showed
thyroid-stimulating
antibodies
enhanced.
4,
previous
hypothyroidism
had
an
increase
in
thyroid-related
antibody
(TPOAb
TRAb)
activity
followed
marked
hypothyroidism.
5,
no
developed
controllable
“thyrotoxicosis”
suggesting
painless
thyroiditis.
Conclusion
case
reports
show
change
trend
is
closely
related
response
induced
Frontiers in Endocrinology,
Год журнала:
2022,
Номер
13
Опубликована: Июнь 3, 2022
The
coronavirus
disease
2019
(COVID-19)
pandemic
has
caused
substantial
threats
to
people's
physical
health
and
lives,
claiming
the
lives
of
over
5
million
people
worldwide.
It
is
imperative
identify
severity
intervene
with
effective
therapy
as
early
possible.
Previous
studies
have
shown
that
low
free
triiodothyronine
(FT3)
may
possess
predictive
value
on
COVID-19
prognosis.In
this
retrospective
cohort
study,
15-day
clinical
laboratory
data
186
hospitalized
patients
after
admission
were
analyzed.
Groups
based
COVID-19,
survival
or
non-survival,
presence
absence
euthyroid
sick
syndrome
(ESS).
Categorical
variables
compared
chi-square
test
Fisher's
exact
test.
Continuous
tested
by
Wilcoxon
rank-sum
for
non-normal
distribution.
Spearman
correlations
used
assess
between
FT3
clinic
parameters
multiple
time
points.The
non-survival
had
significant
lower
levels
(3.24
±
0.42
vs.
4.19
0.08
pmol/L,
p
<
0.05)
thyroid-stimulating
hormone
(TSH)
(0.69
0.19
2.32
0.2
uIU/ml,
0.05),
severe
was
significantly
than
non-severe
(3.67
0.14
4.33
0.09
0.05).
Fifty-nine
cases
diagnosed
ESS.
Compared
non-ESS
patients,
those
ESS
older
higher
proportions
fever,
shortness
breath,
hypertension,
diabetes,
disease,
mortality.
In
addition,
correlation
analysis
showed
positively
related
lymphocyte
count
albumin
negatively
correlated
C-reactive
protein,
erythrocyte
sedimentation
rate,
D-dimer
at
all
points
in
first
15
days
admission.Low
a
prognosis
inflammation/coagulopathy/fibrinolysis.
Cancers,
Год журнала:
2022,
Номер
14(17), С. 4338 - 4338
Опубликована: Сен. 5, 2022
The
COVID-19
pandemic
has
changed
healthcare
systems
around
the
world.
Medical
personnel
concentrated
on
infectious
disease
management
and
treatments
for
non-emergency
diseases
scheduled
surgeries
were
delayed.
We
aimed
to
investigate
change
in
severity
of
thyroid
cancer
before
after
outbreak
Korea.
collected
three
years
data
(2019,
2020,
2021)
patients
who
received
surgery
a
university
hospital
South
Korea
grouped
them
as
"Before
COVID-19",
"After
1-year"
2-years".
total
number
annual
outpatients
declined
significantly
both
new
(1303,
939,
1098
patients)
follow-up
(5584,
4609,
4739
patients).
Clinical
characteristics,
including
age,
sex,
BMI,
preoperative
cytology
results,
surgical
extent,
final
pathologic
diagnosis,
not
COVID-19.
However,
days
from
first
visit
was
increased
(38.3
±
32.2,
58.3
105.2,
47.8
124.7
days,
p
=
0.027).
Papillary
carcinoma
(PTC)
showed
proportions
extrathyroidal
extension,
lymphatic
invasion,
vascular
cervical
lymph
node
metastasis.
Increased
tumor
size
observed
with
follicular
(3.5
2.2,
4.0
1.9,
4.3
2.3
cm,
0.019).
After
outbreak,
poor
prognostic
factors
increased,
an
increase
tumors
observed.
Due
our
study
being
confined
single
tertiary
institution
Incheon
city,
Korea,
nationwide
studies
that
include
primary
clinics
should
be
required
identify
actual
impact
treatment.
