International Journal of Ecophysiology,
Год журнала:
2023,
Номер
5(1), С. 13 - 18
Опубликована: Фев. 28, 2023
Hyperuricemia
is
defined
as
a
metabolic
syndrome
disease
with
markers
characteristic
of
uric
acid
production
that
exceed
normal
limits.
Normal
levels
range
from
3.4-7.0
mg/dl
in
adult
men
and
2.4
-6.0
women.
So
if
the
limit,
it
will
cause
can
not
be
fully
metabolized
hyperuricemia.
About
70%
excreted
through
kidneys.
The
kidneys
are
therefore
organs
have
an
important
role
maintaining
homeostasis
general,
complex
molecular
mechanisms.
Reabsorption
occurs
by
URAT1
GLUT9
has
human
body,
where
reabsorbed
then
flowed
back
into
blood
so
affects
body.
Preliminary
data
showed
ethanol
extract
melinjo
skin
contains
3
main
Flavonoid
compounds
higher
Binding
affinity
value
compared
to
allopurinol,
effect
overcoming
levels.
Basic and Clinical Andrology,
Год журнала:
2025,
Номер
35(1)
Опубликована: Янв. 26, 2025
Abstract
The
serendipitous
discovery
that
inhibiting
type
5
phosphodiesterase
(PDE5)
using
sildenafil,
a
potent
PDE5
inhibitor
(PDE5i)
initially
developed
for
cardioprotection,
introduced
the
possibility
of
orally
managing
erectile
dysfunction
(ED)
led
to
an
increase
in
research
data,
which
are
currently
considered
groundbreaking
new
discipline
sexual
medicine.
Findings
from
number
laboratories
and
clinics
around
world
unanimously
demonstrated
following:
(i)
major
cause
ED
is
directly
or
indirectly
related
cardiovascular
disease
(CVD);
(ii)
CVDs
share
same
risk
factors,
mainly
lifestyle
choices;
(iii)
first
therapeutic
approach
both
transform
harmful
lifestyles
into
virtuous
lifestyles;
(iv)
PDE5is
general,
particularly
very
safe,
if
not
protective,
use
CVD
patients.
However,
has
faced
several
challenges.
Many
patients
some
healthcare
providers
(HCPs)
often
misconception
these
drugs
can
CVD.
Some
might
desire
fulfill
unmet
need
privacy
linked
stigma
being
treated
be
enticed
by
idea
buying
online,
either
because
shame
cheaper
prices,
without
knowing
risks
associated
with
counterfeit
drugs.
aim
this
narrative
revision
current
literature
demonstrate
orodispersible
film
sildenafil
safe
CV
perspective;
it
discreet
formulation
respects
privacy;
virtually
unique
PDE5i
too
expensive
produce
outside
correct
channels,
making
impossible
counterfeit.
International Journal of Women s Health,
Год журнала:
2025,
Номер
Volume 17, С. 33 - 42
Опубликована: Янв. 1, 2025
Background:
Few
studies
have
evaluated
the
correlation
between
serum
uric
acid
(SUA)
levels
and
prevalence
of
female
infertility
in
general
population,
effect
magnesium
intake
on
this
has
not
been
investigated.
Methods:
All
participants
aged
18–
45
years
at
baseline
were
enrolled
from
National
Health
Nutritional
Examination
Surveys
(NHANES)
2013–
2018.
The
continuous
variable
SUA
was
divided
into
quartile
(Q1:
≤
3.7
mg/dL,
Q2:
3.7–
4.4
Q3:
4.4–
5.1
Q4:
≥
mg/dL).
Multivariable
logistic
regression
used
to
estimate
odds
ratios
(OR)
95%
confidence
intervals
(CI).
Dietary
two
groups
based
median
number
(low
intake,
<
243
mg/day;
high
mg/day).
Results:
A
total
3185
included
final
analysis,
10.58%
whom
infertile.
In
full
adjustment
model,
positively
associated
with
(OR=1.13,
CI:
1.01–
1.27).
Compared
lowest
(Q1),
highest
(Q4)
had
an
increased
risk
by
62%
(OR=1.62,
1.1–
2.4).
Moreover,
we
found
interactive
association
adjusted
models
(interaction
likelihood
ratio
test:
P=0.029),
implying
that
may
ameliorate
infertility.
Conclusion:
This
study
is
first
report
dietary
relationship
Plain
Language
Summary:
Infertility
affects
approximately
15%
reproductive-aged
couples
worldwide.
population.
role
through
its
effects
We
present
existed,
which
implied
casts
a
light
how
infertility,
hinting
importance
supplementing
various
ways.
Keywords:
acid,
dietary,
BMC Women s Health,
Год журнала:
2023,
Номер
23(1)
Опубликована: Март 11, 2023
There
is
limited
concrete
evidence
connecting
serum
uric
acid
levels
to
female
infertility.
Therefore,
this
study
aimed
find
out
if
are
independently
related
infertility.From
the
National
Health
and
Nutrition
Examination
Survey
(NHANES)
2013-2020,
a
total
sample
of
5872
chosen
participants
between
ages
18
49
were
identified
for
cross-sectional
study.
The
(mg/dL)
each
participant
tested,
reproductive
health
questionnaire
was
used
evaluate
subject's
status.
Both
in
analyses
full
subgroup,
logistic
regression
models
relationship
two
variables.
A
stratified
multivariate
model
perform
subgroup
analysis
based
on
levels.Infertility
found
649
(11.1%)
5,872
adults
study,
with
greater
mean
(4.7
mg/dL
vs.
4.5
mg/dL).
Serum
associated
infertility
both
initial
adjusted
models.
According
regression,
odds
be
significantly
higher
rising
(Q4
[≥
5.2
mg/dL]
Q1
[≤
3.6
mg/dL]),
ratio
[aOR]
=
1.59,
p
0.002].
data
suggests
that
there
dose-response
two.The
results
from
nationally
representative
United
States
confirmed
idea
link
increased
Future
research
necessary
explicate
underlying
mechanisms
relationship.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 3073 - 3073
Опубликована: Март 27, 2025
Erectile
dysfunction
(ED)
is
a
prevalent
condition
affecting
male
sexual
health,
characterized
by
the
inability
to
achieve
or
maintain
satisfactory
erections.
ED
has
multifactorial
pathogenesis
in
which
psychological,
hormonal,
neurologic,
cardiovascular,
and
lifestyle
factors
all
contribute
progressive
decline
of
erectile
function.
A
critical
underlying
mechanism
involves
oxidative
stress
(OS),
an
imbalance
between
reactive
oxygen
species
(ROS)
production
antioxidant
defenses,
disrupts
endothelial
function,
reduces
nitric
oxide
(NO)
bioavailability,
contributes
vascular
dysfunction.
This
narrative
review
explores
interplay
OS
ED,
focusing
on
roles
ROS
sources
such
as
NADPH
oxidase,
xanthine
uncoupled
synthase,
mitochondrial
It
examines
impact
chronic
conditions
like
hypertension,
diabetes
mellitus,
hyperlipidemia,
hypogonadism,
smoking
obesity,
exacerbate
through
systemic
effects.
Emerging
research
underscores
potential
therapies
interventions
restore
redox
balance,
improve
mitigate
ED's
progression.
also
highlights
gaps
understanding
molecular
pathways
linking
emphasizing
need
for
further
develop
targeted
therapeutic
strategies.
