Incorporation of polylactic acid microplastics into the carbon cycle as a carbon source to remodel the endogenous metabolism of the gut

Proceedings of the National Academy of Sciences, Год журнала: 2025, Номер 122(19)

Опубликована: Май 5, 2025

Biodegradable polylactic acid (PLA) plastics have been praised as an effective solution to the global pollution caused by petroleum-based plastics, and their widespread use in food packaging disposable tableware has resulted increased oral exposure PLA microplastics (PLA-MPs). Despite eco-friendly biodegradable reputation, vivo behaviors of PLA-MPs concerning fermentation, carbon cycle, adverse effects remain unknown. Here, we showed that gut microbiota from colon can effectively degrade secreting esterase FrsA, whereas FrsA-producing bacteria were identified dominate this behavior male C57BL/6 mice. Using isotope tracing multiomics techniques, uncovered 13 C-labeled incorporated into cycle a source. Meanwhile, these degraded fragments entered succinate pathway tricarboxylic within epithelial cells. These processes altered metabolic phenotype gut, resulting decreased linear short-chain fatty acids are primary energy sources epithelium. Furthermore, found significantly reduced appetite body weight Our findings present overall process hosts, with focus on entire double which offers indispensable insights potential impact PLA-MPs.

Язык: Английский

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Erectile Dysfunction: Pharmacological Pathways with Understudied Potentials

Biomedicines, Год журнала: 2022, Номер 11(1), С. 46 - 46

Опубликована: Дек. 25, 2022

Erectile dysfunction (ED) is a public health concern worldwide. In the past, it was perceived as phenomenon attributed to age advancement. However, more individuals are affected every year that do not fall under criterion. Epidemiological research revealed this abnormality has an association with endothelial connected several cardiovascular (CV) risk factors. Currently, ED interpreted clinical marker for future adverse events and only present issue negatively affects quality of life. The management involves lifestyle modifications, therapeutic optimization comorbid conditions, pharmacological psychosexual therapy. Phosphodiesterase type 5 (PDE5) inhibitors first-line agents be prescribed such condition. Nonetheless, other pathways remain underinvestigated or were investigated at some stage. This review aimed researchers interested in field showed favorable effects on limited number studies human subjects experimental models.

Язык: Английский

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Risk of Erectile Dysfunction in Male Patients with Gout Treated with Febuxostat or Allopurinol: A Propensity Score-Matched Cohort Study

Drugs, Год журнала: 2022, Номер 82(18), С. 1717 - 1726

Опубликована: Дек. 1, 2022

Язык: Английский

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The Independent Value of Neutrophil to Lymphocyte Ratio in Gouty Arthritis: A Narrative Review

Journal of Inflammation Research, Год журнала: 2023, Номер Volume 16, С. 4593 - 4601

Опубликована: Окт. 1, 2023

Abstract: Since the incidence of gouty arthritis (GA) exhibits yearly increases, accurate assessment and early treatment have significant values for improving disease conditions monitoring prognosis. Neutrophil to lymphocyte ratio (NLR) is a common indicator in blood routine, which has characteristics easy access low cost. In recent years, NLR been proven be an effective guiding diagnosis, treatment, prognosis various diseases. Moreover, varying degrees relationship with inflammatory biomarkers, can affect reflect response body. This paper reviews independent value GA its underlying molecular pathological mechanisms, intending contribute further application NLR. Keywords: neutrophil ratio, arthritis, response, neutrophils, activity

Язык: Английский

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Uncovering the link between inflammatory rheumatic diseases and male reproductive health: a perspective on male infertility and sexual dysfunction

Rheumatology International, Год журнала: 2024, Номер 44(9), С. 1621 - 1636

Опубликована: Май 2, 2024

Abstract Inflammatory rheumatic diseases (IRDs) refer to a range of persistent disorders that have major influence on several physiological systems. Although there is much evidence connecting IRDs sexual dysfunction and fertility problems, research specifically focusing male infertility in relation these sparse. This review addresses the complicated connection between infertility, emphasising physiological, psychological, pharmacological aspects reproductive health outcomes men with conditions. We explore effects their treatments many facets well-being, encompassing functionality, semen characteristics, hormonal balance. Additionally, we present comprehensive analysis knowledge impact categories anti-rheumatic drugs function. an increasing awareness need addressing concerns individuals IRDs, noticeable lack especially dedicated infertility. Moving forward, more needed determine prevalence, risk factors, mechanisms driving difficulties males IRDs. can better assist requirements IRD patients by expanding our understanding setting implementing holistic methods care.

Язык: Английский

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Gout: global epidemiology, risk factors, comorbidities and complications: a narrative review

BMC Musculoskeletal Disorders, Год журнала: 2024, Номер 25(1)

Опубликована: Дек. 19, 2024

Язык: Английский

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Effect of the new 75-mg orodispersible film of sildenafil on erection and sexual quality of life: insights from an observational study

Sexual Medicine, Год журнала: 2023, Номер 11(2)

Опубликована: Март 1, 2023

Abstract Background The newly devised orodispersible film (ODF) of sildenafil is the first phosphodiesterase type 5 inhibitor (PDE5i) available in a 75-mg dose. This intermediate dose and particular properties ODF formulation can improve clinical management erectile dysfunction (ED) patients. Aim We investigated effects on both sexual quality life function based results from an observational study daily practice Italy. Methods was post hoc analysis observational, real-life carried out ED patients at 6 treatment centers All subjects were asked to take prescribed inclusion (visit 1) return for control visit 2) confirm or adapt after minimum 4 weeks. An end 3) performed additional Outcomes Erectile function, assessed by International Index Function–Erectile Function (IIEF-EF) domain; life, measured using instrument men (SQoL-M). Results Among 36 initially recruited dose, dropped (2 2 3 3), none whom due inefficacy serious adverse events. At 2, mean (SD) IIEF-EF scores significantly increased (∆ = 7.97 [4.71], P < 0.0001) as SQoL-M also did 10.76 [10.46], 0.0001). 3, still improved compared baseline 10.64 [7.01], 0.0001, ∆ 18.15 [12.32], respectively). By ANCOVA, we found no significant age, BMI, previous use PDE5i, presence metabolic comorbidities, smoking habits outcomes visits 3. Clinical implication new safe effective ED, improving undergoing treatment. Strengths limitations assessing efficacy setting. However, small sample size, possible underlying cultural factors, limited availability clinically relevant data may have affected reliability our results. Conclusion 75 mg represents novel option

Язык: Английский

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The Role of the “Anti-Inflammatory” Couple for the Management of Hyperuricemia With Deposition

Sexual Medicine, Год журнала: 2022, Номер 10(5), С. 100562 - 100562

Опубликована: Сен. 7, 2022

Abstract Introduction Gout is the most prevalent inflammatory crystal arthropathy worldwide and a chronic disease requiring strict, lifelong adherence to drug therapy healthy lifestyles. has heavy burden on patient's sexual health, owing associated status, long-term complications, pain; however, effects of gout also extend partner's health. Aims We aimed investigate how presence partner could influence complex interaction between risk factors for dysfunctions in order define novel strategies improve health management. Methods Clinical experimental data role couple diseases, as well association were searched through Pubmed. Main outcome measures Evidence from studies describing leveraging can management clinical outcomes diseases. Results Treatment patients their partners; likewise, by it would be possible promote better health-seeking behaviors, ultimately improving implications Promoting awareness relevance potentially pivotal strategy prevent progression subclinical overt forms. Strengths limitations Identifying bidirectional paves way improved control development couples affected gout. However, not been adequately addressed management, evidence comes other Conclusion Improving results vice-versa promoting The improves behavioral well-being patients, with beneficial both

Язык: Английский

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Testosterone and aging male, a perspective from a developing country

The Aging Male, Год журнала: 2023, Номер 26(1)

Опубликована: Июнь 19, 2023

Hypogonadism is associated with a wide range of physical and psychological symptoms that can affect the overall health men. However, in developing country, there are several imposing challenges diagnosis treatment hypogonadism, including lack awareness understanding condition among healthcare providers patients, limited resources high cost treatment. This review aimed to examine potential benefits risks testosterone replacement therapy (TRT) provides perspective country on topic.A comprehensive literature was conducted gather relevant information impact deficiency ageing males effectiveness TRT for treating hypogonadism. Published peer-reviewed articles were analyzed evaluate TRT. Additionally, unique faced hypogonadism considered.Testosterone has been shown be an effective particularly symptomatic men low levels. It offers such as improvements quality life. side effects need considered. In resource constraints, costs pose additional barriers accessing care.In conclusion, holds promise but its implementation accessibility face significant country. Addressing these challenges, raising awareness, allocating resources, finding cost-effective solutions, crucial ensuring settings receive appropriate Further research efforts needed improve management countries optimize affected individuals.

Язык: Английский

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Efficacy and safety of PDE5 inhibitors in middle-aged and old patients with and without hypogonadism

The Aging Male, Год журнала: 2023, Номер 27(1)

Опубликована: Дек. 26, 2023

Purpose Although several reviews have evaluated the use of PDE5 inhibitors (PDE5i) for treating erectile dysfunction (ED), their specific in middle-aged and old patients has not been fully evaluated. Given that elderly with ED often a complex combination systemic sexual health risk factors, safety efficacy PDE5i such context are hereby reviewed.

Язык: Английский

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