Metabolic syndrome and erectile dysfunction: a systematic review and meta-analysis study

Journal of Endocrinological Investigation, Год журнала: 2023, Номер 46(11), С. 2195 - 2211

Опубликована: Июль 29, 2023

Язык: Английский

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Infection, inflammation, and sexual function in male and female patients—recommendations from the Fifth International Consultation on Sexual Medicine (ICSM 2024)

Sexual Medicine Reviews, Год журнала: 2025, Номер unknown

Опубликована: Апрель 30, 2025

Язык: Английский

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Princeton IV consensus guidelines: PDE5 inhibitors and cardiac health

The Journal of Sexual Medicine, Год журнала: 2023, Номер 21(2), С. 90 - 116

Опубликована: Дек. 26, 2023

Abstract Background In 1999, 1 year after the approval of first oral phosphodiesterase type 5 (PDE5) inhibitor for treatment erectile dysfunction (ED), Princeton Consensus Conference was held to address clinical management men with ED who also had cardiovascular disease. These issues were readdressed in second and third conferences. 13 years since last Conference, experience PDE5 inhibitors is more robust, recent new data have emerged regarding not only safety drug–drug interactions, but a potential cardioprotective effect these drugs. Aim March 2023, an interdisciplinary group scientists practitioners met fourth Guidelines at Huntington Medical Research Institutes Pasadena, California, readdress workup presenting as well approach known Method A series lectures from experts field followed by Delphi-type discussions developed reach consensus. Outcomes reached number related interaction health phosphodiesterase-5 inhibitors. Results An algorithm based on recommendations American College Cardiology Heart Association, including use computed tomography coronary artery calcium scoring, integrated into evaluation ED. Additionally, issue nitrate further considered patients Other topics included psychological benefits treating it; mechanism action inhibitors; interactions; optimizing rare adverse events; observed retrospective studies; adulteration dietary supplements pros cons over-the-counter non–PDE5 therapy restorative therapies such stem cells, platelet-rich plasma, shock therapy; other therapies, injection penile prostheses; effectiveness women; future studies sexual discussed. Clinical Implications Algorithms tables help guide clinician dealing risk Strengths Limitations include expertise participants consensus recommendations. that United States this particular meeting. Conclusion The intersection between remains important topic suggesting

Язык: Английский

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Investigating in-vitro functionality and in-vivo taste assessment of eco-friendly Tadalafil Pastilles

Heliyon, Год журнала: 2024, Номер 10(8), С. e29543 - e29543

Опубликована: Апрель 1, 2024

Tadalafil (TDL) has poor bioavailability due to the less aqueous solubility and bitter taste. Oral solid dosage forms, especially tablets, have a broad market worldwide. Constraints of tablets are long process, pollution, high processing cost, requiring more excipient. The research was performed optimize an eco-friendly immediate-acting pastille TDL put forward alternate formulation tablet using advanced data mining tools. Another objective is assess taste masking Brief Access Taste Aversion

Язык: Английский

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XGBoost model for predicting erectile dysfunction risk after radical prostatectomy: development and validation using machine learning

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Май 19, 2025

Язык: Английский

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Management of Persistent Erectile Dysfunction after COVID-19 Infection: An 18-Month Follow-Up Case Report

Sexes, Год журнала: 2023, Номер 4(1), С. 55 - 64

Опубликована: Янв. 24, 2023

The coronavirus disease 2019 (COVID-19) is an emerging pandemic caused by a novel (SARS-CoV-2). Since December the new virus has spread all over world and become major health problem also because of public measures that could affect people’s sexual activity. We report case 35-year-old married male admitted to andrology outpatient clinic in July 2021 sudden onset erectile dysfunction (ED). diagnostic workup showed no risk factor for ED, normal levels testosterone, increased endothelial markers, such as CRP (C-Reactive Protein) Endothelin-1, reduced Vitamin D (VD) levels. Dynamic penile duplex ultrasound (D-PDU) revealed dysfunctional arterial flow. five-item International Index Erectile Function (IIEF-5) Short-Form Health Survey (SF-36) reduction domain scores. patient, initially unresponsive high dose oral phosphodiesterase 5 inhibitors (PDE-5is), was treated with vitamin-D then submitted LI-SWT (low intensity shockwave treatment), progressive clinical benefit at 12-month follow-up. After 18 months, hormone persisted ranges, consistent Endothelin-1. Additionally, IIEF-5, SF-36 flow significantly improved follow-up period. Thus far, function restored patient more PDE-5i.

Язык: Английский

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Impact du COVID-19 sur la fonction érectile : une étude comparative d’une série des cas avant et après la guérison

Annales Africaines de Medecine, Год журнала: 2024, Номер 17(3), С. e5652 - e5664

Опубликована: Июнь 28, 2024

Contexte & objectif: Plusieurs auteurs ont démontré l’influence de la COVID-19 sur fonction érectile. En Afrique Subsaharienne, les données y relatives restent paradoxalement fragmentaires. L’objectif présente étude était d’évaluer l’impact COVID -19 érectile des patients suivis et guéris cette affection dans notre milieu. Méthodes: Il s’agissait d’une série cas à visée analytique qui s’est déroulée au sein du Centre traitement (CTC) Cliniques Universitaires Kinshasa. L’évaluation dysfonction (DE) a été faite base fiche d’enquête contenant le questionnaire IIEF-5. Résultats: Au total, 198 enrôlés. Leur âge moyen 43 ± 14 ans (extrêmes 19 67 ans). Comparée avant COVID-19, proportion avec DE augmenté significativement 49, 5 % 60, 6 après (p < 0,01). L’âge, l’obésité, diabète sucré, l’HTA, l’alcool l’état civil étaient associés l’apparition COVID-19. analyse multivariée, l’âge ≥ 50 ans, l’HTA consommation d’alcool indépendamment DE, multipliant ce risque respectivement, par ; 3 6,1 8. Conclusion. Les atteints COVID19 avaient une prévalence élevée English title: Impact of on erectile function: comparative study series cases before and after recovery Context objective: Several authors have demonstrated the influence function. In Sub-Saharan Africa, there is not enough information assessing relationship between This aimed to evaluate impact function who were hospitalized cured in Methods: descriptive with analytical purposes took place within Patient Treatment Center Kinshasa University Hospital. The evaluation dysfunction (ED) was carried out basis survey form containing IIEF-5 questionnaire. Results: average age years extremes years. ED present 49.5% compared 60.6% from Age, obesity, diabetes mellitus, hypertension, alcohol marital status significantly associated onset multivariate analysis, years, hypertension consumption multiplied this risk respectively by 5; 3; 6; 6.1 Conclusion: Patients had high prevalence ED.

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Development of a Machine Learning-Based Model for the Prediction of Long-Term Erectile Dysfunction after COVID-19 Recovery: A Prospective Observational Study

Опубликована: Июль 22, 2024

Objectives: To develop a machine learning-based model for the identification of features involved in prediction long-term erectile dysfunction (ED) after COVID-19 recovery. Methods: We performed an observational prospective multicentre study. Participants were divided into 2 groups: I) Patients with past history COVID-19; II) without previous microbiological diagnosis COVID-19. A total 361 patients (COVID-19 group, n=166, Control group; n=195) assessed from January 2022 to March 2023. group 12 months recovery; within same time window. The primary outcome measure was ED. including three algorithms (random forest, logistic regression and support vector machines [SVM]) applied perform automatic selection those algorithm SVM-recursive feature elimination (RFE) also executed. Results: median age 55 years both groups. final variables our was: SARS-CoV-2 vaccination status, hypertension, diabetes, beta blocker treatment, antiplatelet therapy coffee intake. SVM-RFE showed that ED predictors model. Conclusions: developed following application predictive tool community setting could avoid adverse effects unfavourable economic impact associated.

Язык: Английский

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An overview of conventional and investigational phosphodiesterase 5 inhibitors for treating erectile dysfunction and other conditions

Expert Opinion on Investigational Drugs, Год журнала: 2024, Номер 33(9), С. 925 - 938

Опубликована: Авг. 3, 2024

There is a rising concern about developing innovative, efficacious PDE5I molecules that provide better safety, efficacy, and tolerability with less adverse effects. Innovative dual targets have also been defined in the literature. Additionally, some of are able to selectively inhibit other enzymes such as histone deacetylase, acetylcholine esterase, cyclooxygenase or act nitric oxide donors. This review presents knowledge concerning advanced trends perspectives using treatment ED conditions.

Язык: Английский

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Update on andrological effects of SARS‐CoV‐2 infection and COVID‐19: An overview review

Andrology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 31, 2024

Evidence indicates a wide range of andrological alterations in patients with the Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) infection and Coronavirus Disease 2019 (COVID-19).

Язык: Английский

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