Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 18, 2023
Abstract
Background
There
are
currently
no
studies
exploring
omicron
infection
and
male
sexual
function
semen
quality.
Our
aim
was
to
estimate
changes
in
quality
men
recovering
from
since
the
Omicron
pandemic
started
China
late
2022.
Methods
We
collected
1540
questionnaires
assessed
before
acute
phase
after
by
using
International
Index
of
Erectile
Function-5,
Premature
Ejaculation
Diagnostic
Tool,
Arizona
Sexual
Experience
Scale.
also
analysis
results
247
patients.
Results
During
infection,
proportion
erectile
dysfunction
significantly
higher
than
but
ejaculatory
not
altered;
In
addition,
showed
significant
difference
concentration,
activity
PR
a
+
b
sperm
forward
movement
compared
pre-infection.
Conclusions
can
affect
as
well
experience
patients
phase.
The
risk
factors
for
decreased
due
included
body
temperature
anxiety
during
infection.
Trial
registration:
study
registered
with
ClinicalTrials.gov
approved
Ethics
Committee
Xiangya
Medical
College.
The Journal of Sexual Medicine,
Год журнала:
2023,
Номер
21(2), С. 90 - 116
Опубликована: Дек. 26, 2023
Abstract
Background
In
1999,
1
year
after
the
approval
of
first
oral
phosphodiesterase
type
5
(PDE5)
inhibitor
for
treatment
erectile
dysfunction
(ED),
Princeton
Consensus
Conference
was
held
to
address
clinical
management
men
with
ED
who
also
had
cardiovascular
disease.
These
issues
were
readdressed
in
second
and
third
conferences.
13
years
since
last
Conference,
experience
PDE5
inhibitors
is
more
robust,
recent
new
data
have
emerged
regarding
not
only
safety
drug–drug
interactions,
but
a
potential
cardioprotective
effect
these
drugs.
Aim
March
2023,
an
interdisciplinary
group
scientists
practitioners
met
fourth
Guidelines
at
Huntington
Medical
Research
Institutes
Pasadena,
California,
readdress
workup
presenting
as
well
approach
known
Method
A
series
lectures
from
experts
field
followed
by
Delphi-type
discussions
developed
reach
consensus.
Outcomes
reached
number
related
interaction
health
phosphodiesterase-5
inhibitors.
Results
An
algorithm
based
on
recommendations
American
College
Cardiology
Heart
Association,
including
use
computed
tomography
coronary
artery
calcium
scoring,
integrated
into
evaluation
ED.
Additionally,
issue
nitrate
further
considered
patients
Other
topics
included
psychological
benefits
treating
it;
mechanism
action
inhibitors;
interactions;
optimizing
rare
adverse
events;
observed
retrospective
studies;
adulteration
dietary
supplements
pros
cons
over-the-counter
non–PDE5
therapy
restorative
therapies
such
stem
cells,
platelet-rich
plasma,
shock
therapy;
other
therapies,
injection
penile
prostheses;
effectiveness
women;
future
studies
sexual
discussed.
Clinical
Implications
Algorithms
tables
help
guide
clinician
dealing
risk
Strengths
Limitations
include
expertise
participants
consensus
recommendations.
that
United
States
this
particular
meeting.
Conclusion
The
intersection
between
remains
important
topic
suggesting
Heliyon,
Год журнала:
2024,
Номер
10(8), С. e29543 - e29543
Опубликована: Апрель 1, 2024
Tadalafil
(TDL)
has
poor
bioavailability
due
to
the
less
aqueous
solubility
and
bitter
taste.
Oral
solid
dosage
forms,
especially
tablets,
have
a
broad
market
worldwide.
Constraints
of
tablets
are
long
process,
pollution,
high
processing
cost,
requiring
more
excipient.
The
research
was
performed
optimize
an
eco-friendly
immediate-acting
pastille
TDL
put
forward
alternate
formulation
tablet
using
advanced
data
mining
tools.
Another
objective
is
assess
taste
masking
Brief
Access
Taste
Aversion
The
coronavirus
disease
2019
(COVID-19)
is
an
emerging
pandemic
caused
by
a
novel
(SARS-CoV-2).
Since
December
the
new
virus
has
spread
all
over
world
and
become
major
health
problem
also
because
of
public
measures
that
could
affect
people’s
sexual
activity.
We
report
case
35-year-old
married
male
admitted
to
andrology
outpatient
clinic
in
July
2021
sudden
onset
erectile
dysfunction
(ED).
diagnostic
workup
showed
no
risk
factor
for
ED,
normal
levels
testosterone,
increased
endothelial
markers,
such
as
CRP
(C-Reactive
Protein)
Endothelin-1,
reduced
Vitamin
D
(VD)
levels.
Dynamic
penile
duplex
ultrasound
(D-PDU)
revealed
dysfunctional
arterial
flow.
five-item
International
Index
Erectile
Function
(IIEF-5)
Short-Form
Health
Survey
(SF-36)
reduction
domain
scores.
patient,
initially
unresponsive
high
dose
oral
phosphodiesterase
5
inhibitors
(PDE-5is),
was
treated
with
vitamin-D
then
submitted
LI-SWT
(low
intensity
shockwave
treatment),
progressive
clinical
benefit
at
12-month
follow-up.
After
18
months,
hormone
persisted
ranges,
consistent
Endothelin-1.
Additionally,
IIEF-5,
SF-36
flow
significantly
improved
follow-up
period.
Thus
far,
function
restored
patient
more
PDE-5i.
Annales Africaines de Medecine,
Год журнала:
2024,
Номер
17(3), С. e5652 - e5664
Опубликована: Июнь 28, 2024
Contexte
&
objectif:
Plusieurs
auteurs
ont
démontré
l’influence
de
la
COVID-19
sur
fonction
érectile.
En
Afrique
Subsaharienne,
les
données
y
relatives
restent
paradoxalement
fragmentaires.
L’objectif
présente
étude
était
d’évaluer
l’impact
COVID
-19
érectile
des
patients
suivis
et
guéris
cette
affection
dans
notre
milieu.
Méthodes:
Il
s’agissait
d’une
série
cas
à
visée
analytique
qui
s’est
déroulée
au
sein
du
Centre
traitement
(CTC)
Cliniques
Universitaires
Kinshasa.
L’évaluation
dysfonction
(DE)
a
été
faite
base
fiche
d’enquête
contenant
le
questionnaire
IIEF-5.
Résultats:
Au
total,
198
enrôlés.
Leur
âge
moyen
43
±
14
ans
(extrêmes
19
67
ans).
Comparée
avant
COVID-19,
proportion
avec
DE
augmenté
significativement
49,
5
%
60,
6
après
(p
<
0,01).
L’âge,
l’obésité,
diabète
sucré,
l’HTA,
l’alcool
l’état
civil
étaient
associés
l’apparition
COVID-19.
analyse
multivariée,
l’âge
≥
50
ans,
l’HTA
consommation
d’alcool
indépendamment
DE,
multipliant
ce
risque
respectivement,
par
;
3
6,1
8.
Conclusion.
Les
atteints
COVID19
avaient
une
prévalence
élevée
English
title:
Impact
of
on
erectile
function:
comparative
study
series
cases
before
and
after
recovery
Context
objective:
Several
authors
have
demonstrated
the
influence
function.
In
Sub-Saharan
Africa,
there
is
not
enough
information
assessing
relationship
between
This
aimed
to
evaluate
impact
function
who
were
hospitalized
cured
in
Methods:
descriptive
with
analytical
purposes
took
place
within
Patient
Treatment
Center
Kinshasa
University
Hospital.
The
evaluation
dysfunction
(ED)
was
carried
out
basis
survey
form
containing
IIEF-5
questionnaire.
Results:
average
age
years
extremes
years.
ED
present
49.5%
compared
60.6%
from
Age,
obesity,
diabetes
mellitus,
hypertension,
alcohol
marital
status
significantly
associated
onset
multivariate
analysis,
years,
hypertension
consumption
multiplied
this
risk
respectively
by
5;
3;
6;
6.1
Conclusion:
Patients
had
high
prevalence
ED.
Objectives:
To
develop
a
machine
learning-based
model
for
the
identification
of
features
involved
in
prediction
long-term
erectile
dysfunction
(ED)
after
COVID-19
recovery.
Methods:
We
performed
an
observational
prospective
multicentre
study.
Participants
were
divided
into
2
groups:
I)
Patients
with
past
history
COVID-19;
II)
without
previous
microbiological
diagnosis
COVID-19.
A
total
361
patients
(COVID-19
group,
n=166,
Control
group;
n=195)
assessed
from
January
2022
to
March
2023.
group
12
months
recovery;
within
same
time
window.
The
primary
outcome
measure
was
ED.
including
three
algorithms
(random
forest,
logistic
regression
and
support
vector
machines
[SVM])
applied
perform
automatic
selection
those
algorithm
SVM-recursive
feature
elimination
(RFE)
also
executed.
Results:
median
age
55
years
both
groups.
final
variables
our
was:
SARS-CoV-2
vaccination
status,
hypertension,
diabetes,
beta
blocker
treatment,
antiplatelet
therapy
coffee
intake.
SVM-RFE
showed
that
ED
predictors
model.
Conclusions:
developed
following
application
predictive
tool
community
setting
could
avoid
adverse
effects
unfavourable
economic
impact
associated.
Expert Opinion on Investigational Drugs,
Год журнала:
2024,
Номер
33(9), С. 925 - 938
Опубликована: Авг. 3, 2024
There
is
a
rising
concern
about
developing
innovative,
efficacious
PDE5I
molecules
that
provide
better
safety,
efficacy,
and
tolerability
with
less
adverse
effects.
Innovative
dual
targets
have
also
been
defined
in
the
literature.
Additionally,
some
of
are
able
to
selectively
inhibit
other
enzymes
such
as
histone
deacetylase,
acetylcholine
esterase,
cyclooxygenase
or
act
nitric
oxide
donors.
This
review
presents
knowledge
concerning
advanced
trends
perspectives
using
treatment
ED
conditions.
Evidence
indicates
a
wide
range
of
andrological
alterations
in
patients
with
the
Severe
Acute
Respiratory
Syndrome
CoronaVirus
2
(SARS-CoV-2)
infection
and
Coronavirus
Disease
2019
(COVID-19).