Thyroid Inflammation and Immunity During the COVID-19 Pandemic: A Comprehensive Review and Case Study DOI

Eleni Lampropoulou,

C. Benz,

George J. Kahaly

и другие.

Hormone and Metabolic Research, Год журнала: 2023, Номер 56(02), С. 111 - 117

Опубликована: Дек. 4, 2023

Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2) has led to the development of various vaccines. Reports have emerged suggesting a possible association between SARS-CoV-2 vaccination and onset thyroid diseases. This review explores clinical aspects disorders following vaccination, including case report patient with concomitant subacute thyroiditis (SAT) Graves’ (GD) blocking thyrotropin receptor autoantibodies (TSH-R-Ab) vaccination. SAT, characterized transient inflammation gland, been reported after GD, an autoimmune hyperthyroidism, also observed post-vaccination, often stimulating TSH-R-Ab. orbitopathy (GO) associated in patients history immune disease. unique underscores very rare condition functional hypothyroidism relation usefulness analysis TSH-R-Ab that can provide valuable insights into pathogenesis help guide treatment. highlights need for continued monitoring awareness potential thyroid-related complications

Язык: Английский

COVID-19 vaccination and thyroiditis DOI Open Access
Süleyman Nahit Şendur, Seda Hanife Oğuz, Uğur Ünlütürk

и другие.

Best Practice & Research Clinical Endocrinology & Metabolism, Год журнала: 2023, Номер 37(4), С. 101759 - 101759

Опубликована: Март 3, 2023

Язык: Английский

Процитировано

18
Efficiency and Safety of Tocilizumab for the Treatment of Thyroid Eye Disease: A Systematic Review DOI
Ana Filipa Duarte,

Naiara F. Xavier,

Marco Sales Sanz

и другие.

Ophthalmic Plastic and Reconstructive Surgery, Год журнала: 2024, Номер 40(4), С. 367 - 373

Опубликована: Янв. 12, 2024

Purpose: To review existing literature concerning the effectiveness and safety of tocilizumab (TCZ) for managing thyroid eye disease. Methods: A systematic search was conducted across PubMed Embase databases to identify studies on TCZ therapy, from inception May 2023. The included keywords “Graves orbitopathy,” “thyroid ophthalmopathy,” disease,” “thyroid-associated “endocrine “Tocilizumab.” Only articles written in English, Spanish, or French were considered. Results: Among 1,013 initially screened, a total 29 fulfilled eligibility criteria selected. Most case reports series, only one randomized clinical trial found. has been used mainly glucocorticoid-resistant relapsing cases, with dosage ranging 4 8 mg/kg every weeks when intravenous weekly subcutaneous dose 162 mg. Treatment duration is usually adjusted response. mostly effective reducing inflammatory signs during active phase disease, an improvement at least 3 points activity score overall rate 8.2%. Numerous have shown marked reductions proptosis; although available controlled reported nonstatistically significant 6 months after treatment, recent meta-analysis indicated that seems be most treatment proptosis. No severe side effects related administration reported. Discussion: Despite these promising findings, trials directly compare efficacy other currently therapeutic options are needed.

Язык: Английский

Процитировано

9
Autoimmune thyroid diseases DOI

Luigi Bartalena,

Daniela Gallo, Maria Laura Tanda

и другие.

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 561 - 584

Опубликована: Янв. 1, 2024

Процитировано

3
New-onset Thyroid Eye Disease after COVID-19 Vaccination in a Radioactive Iodine-Treated Graves’ Disease Patient: A Case Report and Literature Review DOI Creative Commons
Jamie Hong Im Teoh, Norlaila Mustafa,

Norasyikin A Wahab

и другие.

Journal of the ASEAN Federation of Endocrine Societies, Год журнала: 2023, Номер 38(1), С. 125 - 130

Опубликована: Март 1, 2023

Autoimmunity associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been well-described as the mechanism of development thyroid dysfunction following Coronavirus Disease 19 (COVID-19) infection and SARS-CoV-2 vaccination. However, occurrence eye disease (TED) after vaccination is scarcely described. The postulated mechanisms include immune reactivation, molecular mimicry autoimmune/inflammatory induced by adjuvants (ASIA). We report a case new-onset TED receiving vaccine.

Язык: Английский

Процитировано

6
SARS-CoV-2-Vaccine-Related Endocrine Disorders: An Updated Narrative Review DOI Creative Commons
Avraham Ishay, Kira Oleinikov, Elena Chertok Shacham

и другие.

Vaccines, Год журнала: 2024, Номер 12(7), С. 750 - 750

Опубликована: Июль 8, 2024

The emergence of the COVID-19 pandemic has led to rapid and worldwide development investigation multiple vaccines. While most side effects these vaccines are mild transient, potentially severe adverse events may occur involve endocrine system. This narrative review aimed explore current knowledge on potential following vaccination, with thyroid disorders being common. Data about pituitary, adrenal, diabetes, gonadal also reviewed. provides a comprehensive understanding pathogenesis associated SARS-CoV-2 PubMed/MEDLINE, Embase database (Elsevier), Google Scholar searches were performed. Case reports, case series, original studies, reviews written in English published online up 31 August 2023 selected accumulating. However, their causal relationship is not strong enough make definite conclusion, further studies needed clarify mechanisms linked

Язык: Английский

Процитировано

1
SARS-CoV-2 Vaccines-Related Endocrine Disorders: An Updated Narrative Review DOI Open Access
Avraham Ishay, Kira Oleinikov, Elena Chertok Shacham

и другие.

Опубликована: Март 6, 2024

Abstract: The emergence of the COVID-19 pandemic has led to rapid and worldwide devel-opment investigation multiple vaccines. While most side effects these vaccines are mild transient, potentially severe adverse events may occur involve endocrine system. This narrative review aims explore current knowledge on potential following vaccination, with thyroid disorders being common. Data about pi-tuitary, adrenal, diabetes, gonadal will also be reviewed. provides a comprehensive understanding pathogenesis associated SARS-CoV-2 A PubMed/MEDLINE, Embase database (Elsevier), Google Scholar research were performed. Case reports case series, original studies, reviews written in English published online up 31 August 2023 selected is accumulating. However, their causal relationship not strong enough make definite conclusion, further studies needed clarify mechanisms linked vac-cines.

Язык: Английский

Процитировано

1
Graves’ disease after COVID mRNA vaccination for the first time diagnosed in adolescence-case report. Cause and effect relationship or simple coincidence? DOI
Francesca Mainieri, Francesco Chiarelli, Corrado Betterle

и другие.

Journal of Pediatric Endocrinology and Metabolism, Год журнала: 2023, Номер 36(10), С. 993 - 997

Опубликована: Авг. 23, 2023

Over the past 3 years, coronavirus disease 2019 with its worldwide spread has profoundly marked public health, therefore anti-COVID-19 vaccinations have been developed to prevent dissemination of disease. To date, 71 cases Graves' (GD) after vaccination against SARS-Cov-2 were described in adult population. Our goal is present first case paediatric population.We a 16-year-old adolescent girl who GD 6-7 weeks second dose mRNA vaccine. Therapy methimazole and propranolol was started, achieving normal thyroid function negativity autoantibodies at time therapy discontinuation 8 months.This shows that development COVID-19 can occur also Nevertheless, small number so far, many millions vaccinations, makes it impossible determine whether this simple coincidence or cause. Further epidemiological data on incidence period compared previous will be able clearly define question.

Язык: Английский

Процитировано

2
REVIEW OF SARS-CORONAVIRUS-2 REPERCUSSIONS ON THYROID GLAND IN THE CONTEXT OF HYPERTHYROIDISM DOI Open Access
S V Singh,

Monika,

Rupa Mazumder

и другие.

International Journal of Applied Pharmaceutics, Год журнала: 2023, Номер unknown, С. 17 - 26

Опубликована: Сен. 7, 2023

The thyroid gland may generate, store, and release hormones (such as Triiodothyronine Thyroxin also called T3 T4 respectively) into the bloodstream let them go to body's cells. Every enzymatic process in production secretion of is controlled by Thyroid stimulating hormone (TSH). All people worldwide are susceptible disease, which often accompanied hyperthyroidism hypothyroidism. thyroid's structural proximity upper airways, a main route for coronavirus entry, holds up idea that might be target Covid-19 or SARS-CoronaVirus-2. When makes secretes too much hormone, it referred if patients do not take any precautions, lead cardiac hypertrophy. epidemic had substantial influence on our daily lives has unexpectedly changed way medical research. This review aimed discuss effects SARS-CoronaVirus-2 Gland Context Hyperthyroidism related causing diseases, highlighting common diseases along with their treatments. We highlight impact its mRNA immunization. So future studies should focus number important advances improved drug management treatment relating triggered

Язык: Английский

Процитировано

2
Thyroid Eye Disease as Initial Manifestation of Graves’ Disease Following Viral Vector SARS-CoV-2 Vaccine: Report of a Case and Review of the Literature DOI Creative Commons
Anastasia Armeni, Georgios Κ. Markantes,

Alexandra Stathopoulou

и другие.

Vaccines, Год журнала: 2023, Номер 11(10), С. 1574 - 1574

Опубликована: Окт. 10, 2023

COVID-19, a contagious disease caused by the novel coronavirus SARS-CoV-2, emerged in 2019 and quickly became pandemic, infecting more than 700 million people worldwide. The incidence, morbidity mortality rates have started to decline since development of effective vaccines against virus widespread immunization population. SARS-CoV-2 are associated with minor local or systemic adverse reactions, while serious effects rare. Thyroid-related disorders been reported after vaccination for Graves’ (GD) is second most common amongst them. Thyroid eye (TED), an extrathyroidal manifestation GD, rarely observed post-COVID-19 vaccination. All TED cases followed mRNA-based vaccinations, but two new onset mild post-viral vector vaccine (ChAdox1nCoV-19) also reported. We report case 63-year-old woman who presented hyperthyroidism moderate-to-severe active 10 days she received first dose viral SARS-CoV-2. This such vaccine. Our patient was initially treated intravenous glucocorticoids, subsequently rituximab, due no response. rendered inactive constant diplopia persisted, referred rehabilitative surgery.

Язык: Английский

Процитировано

1
Letter to the Editor From Lui et al: “Increased Risk of Thyroid Eye Disease Following COVID-19 Vaccination” DOI
David Tak Wai Lui, Carlos King Ho Wong, Kenneth K. C. Man

и другие.

The Journal of Clinical Endocrinology & Metabolism, Год журнала: 2023, Номер 109(3), С. e1315 - e1315

Опубликована: Окт. 17, 2023

Journal Article Letter to the Editor From Lui et al: "Increased Risk of Thyroid Eye Disease Following COVID-19 Vaccination" Get access David Tak Wai Lui, Department Medicine, School Clinical Li Ka Shing Faculty The University Hong Kong, Kong SAR, China Correspondence: MBBS, 102 Pokfulam Rd, Pokfulam, China. Email: [email protected]. https://orcid.org/0000-0002-9813-1126 Search for other works by this author on: Oxford Academic Google Scholar Carlos King Ho Wong, Wong Laboratory Data Discovery Health (D24H), ChinaDepartment Family Medicine and Primary Care, ChinaCentre Safe Medication Practice Research, Pharmacy Pharmacology, https://orcid.org/0000-0002-6895-6071 Kenneth K C Man ChinaResearch Policy, UCL Pharmacy, London WC1H 9JP, UKCentre Medicines Optimisation Research Education, College Hospitals NHS Foundation Trust, NW1 2PB, UK https://orcid.org/0000-0001-8645-1942 Endocrinology & Metabolism, Volume 109, Issue 3, March 2024, Page e1315, https://doi.org/10.1210/clinem/dgad614 Published: 17 October 2023 history Received: 18 September Editorial decision: 25 Corrected typeset:

Язык: Английский

Процитировано

1