Ketogenic diets in chronic kidney disease patients: a review for skeptics by skeptics DOI Creative Commons
Claudia D’Alessandro, Domenico Giannese,

Giorgina Barbara Piccoli

и другие.

Journal of Nephrology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 30, 2025

Abstract Over the last few decades, there has been growing interest in use of ketogenic diets, mainly as a weight loss strategy. Obesity and diabetes are major risk factors for kidney disease, obese patients with chronic disease (CKD) potential candidates reducing among them diets. Of further relevance to nephrology, limited number recent studies suggests favorable effect diets affected by autosomal dominant polycystic (ADPKD). However, concerns remain about safety CKD, particularly long term those poor residual function. The confusion surrounding definition adds these concerns. aim this review is summarize information on main types used daily practice discuss options their implementation CKD patients, limiting ultra-processed or industrial preparations. Although needed identify profile who may benefit from treat obesity slow progression ADPKD, assess short- long-term adherence, available data appear promising. This critical intended stimulate research. Graphical abstract

Язык: Английский

Efficacy and Safety of Phase 1 of Very Low Energy Ketogenic Therapy (VLEKT) in Subjects with Obesity and Mild Renal Impairment DOI Open Access
Ludovica Verde, Luigi Barrea, Marilisa Galasso

и другие.

Nutrients, Год журнала: 2025, Номер 17(4), С. 721 - 721

Опубликована: Фев. 18, 2025

Background: Obesity impairs renal function through direct mechanisms, such as proinflammatory adipocytokine production, and indirect including obesity-related comorbidities. Despite the increasing prevalence of obesity chronic kidney disease (CKD), clinical guidelines for their combined management remain lacking. Very Low Energy Ketogenic Therapy (VLEKT) has demonstrated efficacy in weight loss, but evidence on its safety individuals with mild impairment is limited. This study aimed to assess Phase 1 VLEKT impairment. Methods: cross-sectional included 73 overweight or (mean age 53.7 ± 8.8 years; BMI 35.3 4.2 kg/m2) an estimated glomerular filtration rate (eGFR) at least 60 mL/min/1.73 m2 (evaluated using CKD-EPI equation). Anthropometric (weight, BMI, waist circumference) biochemical parameters (fasting plasma glucose, insulin, cholesterol profile, triglycerides, AST, ALT, urea) were collected baseline after 45 (±2) days VLEKT. Results: At baseline, 54.8% participants had eGFR <90 m2, while 45.2% ≥ 90 no significant differences sex distribution. After VLEKT, both groups showed reductions (p < 0.001), circumference fasting glucose ≤ 0.004), insulin HOMA-IR total LDL LDL/HDL ratio 0.002), triglycerides 0.009), AST 0.034), ALT 0.009). Notably, significantly increased changes observed those m2. Conclusions: could effectively promote loss metabolic improvements without compromising function, even Further research warranted confirm outcomes across all protocol phases.

Язык: Английский

Процитировано

2

Advancing Obesity Management: the Very Low-Energy Ketogenic therapy (VLEKT) as an Evolution of the “Traditional” Ketogenic Diet DOI Creative Commons
Francesco Balestra, Maria De Luca,

G. Panzetta

и другие.

Current Obesity Reports, Год журнала: 2025, Номер 14(1)

Опубликована: Апрель 3, 2025

This narrative review comprehensively analyzes VLEKT as an advanced nutritional strategy for obesity management. The focus is on the beneficial effects key disease organs, such adipose tissue and liver, well modulation of intestinal permeability its fundamental role in influencing gut microbiota inflammatory pathways. impact obesity-related comorbidities, including metabolic syndrome, cardiovascular disease, endocrine disorders, dysfunction-associated steatotic liver (MASLD), neurological kidney alterations, also investigated. Moreover, to assess wider application treatment, combination ketogenic regimes with additional strategies physical activity, bariatric surgery, digital health technologies examined. Despite promising clinical results, adherence potential deficiencies require careful follow-up individualized programming monitored by specialists. Future research should elucidating molecular mechanisms underlying physiological systems, long-term safety. Nevertheless, innovative approach offering a target-oriented highly effective people fighting against overweight associated medical complications. Obesity multifactorial chronic numerous comorbidities; given increasing prevalence, personalized intervention are crucial inhibit "obesity pandemic" according "food re-educational" protocol. Among dietary interventions, diet (KD) has attracted attention effectiveness weight management benefits. A variant, very low-calorie (VLCKD), more recently defined low-energy (VLEKD), combines benefits ketosis substantial calorie restriction, improving overall health.

Язык: Английский

Процитировано

0

Ketogenic diets in chronic kidney disease patients: a review for skeptics by skeptics DOI Creative Commons
Claudia D’Alessandro, Domenico Giannese,

Giorgina Barbara Piccoli

и другие.

Journal of Nephrology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 30, 2025

Abstract Over the last few decades, there has been growing interest in use of ketogenic diets, mainly as a weight loss strategy. Obesity and diabetes are major risk factors for kidney disease, obese patients with chronic disease (CKD) potential candidates reducing among them diets. Of further relevance to nephrology, limited number recent studies suggests favorable effect diets affected by autosomal dominant polycystic (ADPKD). However, concerns remain about safety CKD, particularly long term those poor residual function. The confusion surrounding definition adds these concerns. aim this review is summarize information on main types used daily practice discuss options their implementation CKD patients, limiting ultra-processed or industrial preparations. Although needed identify profile who may benefit from treat obesity slow progression ADPKD, assess short- long-term adherence, available data appear promising. This critical intended stimulate research. Graphical abstract

Язык: Английский

Процитировано

0