Scientific Reports,
Год журнала:
2021,
Номер
11(1)
Опубликована: Июнь 7, 2021
Abstract
Eveningness,
a
preference
for
later
sleep
and
rise
times,
has
been
associated
with
number
of
negative
outcomes
in
terms
both
physical
mental
health.
A
large
body
evidence
links
eveningness
to
Major
Depressive
Disorder
(MDD).
However,
date,
quantifying
this
association
is
limited.
The
current
meta-analysis
included
43
effect
sizes
from
total
27,996
participants.
Using
random-effects
model
it
was
demonstrated
that
small
size
(Fisher’s
Z
=
−
2.4,
95%
CI
[−
0.27.
0.21],
p
<
0.001).
Substantial
heterogeneity
between
studies
observed,
meta-regression
analyses
demonstrating
significant
mean
age
on
the
diurnal
depression.
There
also
potential
publication
bias
as
assessed
by
visual
inspection
funnel
plots
Egger’s
test.
depression
magnitude
heterogenous.
better
understanding
mechanistic
underpinnings
linking
suitably
powered
prospective
allow
causal
inference
are
required.
Translational Psychiatry,
Год журнала:
2024,
Номер
14(1)
Опубликована: Июнь 4, 2024
Abstract
To
advance
the
emergence
of
circadian-based
therapies,
this
study
characterized
how
psychiatric
symptoms
fluctuate
across
day
and
vary
between
individuals.
Using
a
dimensional
approach,
we
determined
chronotype
relates
to
13
traits,
modeled
temporal
development
throughout
using
generalized
additive
mixed
effects
models.
In
preregistered
study,
subclinical
sample
completed
trait
scales
scale
at
baseline
(
N
=
515,
n
404
women,
109
men,
2
non-binary,
M
age
32.4
years,
range
18–77),
followed
by
22
behaviors
rated
repeatedly
~08:00-00:00
410).
Key
findings
are
that
11
out
traits
were
associated
with
being
an
evening-type,
ranging
from
depression
obsessive
comulsive
disorder,
social
anxiety,
delusional
ideation,
while
only
mania
was
morning-type.
Four
distinct
factors
identified,
each
predicting
worse
symptom
levels
day.
Fatigue-related
exhibited
strong
time-of-day
changes
evening-types
experiencing
fatigue
in
morning
morning-types
evening.
Evening-types
had
considerably
lower
drive
motivation
than
early
also
more
pronounced
negative
emotional
ADHD-type
evening,
particularly
among
those
high
factors.
These
identified
important
research
targets
hold
promise
for
improving
mental
health
outcomes,
such
as
strategies
boost
motivation.
Furthermore,
results
emphasize
relevance
incorporating
circadian
factors,
including
chronotype,
into
translational
interventions.
Depression and Anxiety,
Год журнала:
2020,
Номер
37(5), С. 466 - 474
Опубликована: Фев. 17, 2020
Background
Chronotype
is
an
individual's
preferred
timing
of
sleep
and
activity,
often
referred
to
as
a
later
chronotype
(or
evening-type)
or
earlier
morning-type).
Having
evening
associated
with
more
severe
depressive
anxiety
symptoms.
Based
on
these
findings
it
has
been
suggested
that
stable
construct
vulnerability
develop
disorders.
To
examine
this,
we
test
the
stability
over
7
years,
its
longitudinal
association
change
in
severity
Methods
Data
1,417
participants
and/or
disorder
diagnosis
healthy
controls
assessed
at
2
9-year
follow-up
waves
Netherlands
Study
depression
were
used.
was
Munich
questionnaire.
Severity
symptoms
inventory
symptomatology
Beck
inventory.
Results
found
be
moderately
(r
=
0.53)
average
advanced
(i.e.,
became
earlier)
10.8
min
years
(p
<
.001).
Controlling
for
possible
confounders,
decrease
advance
(B
0.008,
p
.003).
A
not
chronotype.
Conclusion
stable,
trait-like
only
minor
level
period
years.
The
depressive,
but
anxiety,
Molecular Psychiatry,
Год журнала:
2021,
Номер
26(11), С. 6305 - 6316
Опубликована: Июнь 8, 2021
Abstract
Late
diurnal
preference
has
been
linked
to
poorer
mental
health
outcomes,
but
the
understanding
of
causal
role
on
and
wellbeing
is
currently
limited.
often
associated
with
circadian
misalignment
(a
mismatch
between
timing
endogenous
system
behavioural
rhythms),
so
that
evening
people
live
more
frequently
against
their
internal
clock.
This
study
aims
quantify
contribution
including
anxiety,
depression
general
test
hypothesis
misaligned
individuals
have
using
an
actigraphy-based
measure
misalignment.
Multiple
Mendelian
Randomisation
(MR)
approaches
were
used
pathways
seven
well-validated
outcomes
in
up
451,025
individuals.
In
addition,
observational
analyses
tested
association
a
novel,
objective
(Composite
Phase
Deviation,
CPD)
outcomes.
Using
genetic
instruments
identified
largest
GWAS
for
preference,
we
provide
robust
evidence
early
protective
improves
wellbeing.
For
example,
one-sample
MR,
twofold
higher
liability
morningness
was
lower
odds
depressive
symptoms
(OR:
0.92,
95%
CI:
0.88,
0.97).
It
possible
factors
may
contribute
chronotype
relationship,
further
work
needed
confirm
these
findings.
Scientific Reports,
Год журнала:
2021,
Номер
11(1)
Опубликована: Июнь 7, 2021
Abstract
Eveningness,
a
preference
for
later
sleep
and
rise
times,
has
been
associated
with
number
of
negative
outcomes
in
terms
both
physical
mental
health.
A
large
body
evidence
links
eveningness
to
Major
Depressive
Disorder
(MDD).
However,
date,
quantifying
this
association
is
limited.
The
current
meta-analysis
included
43
effect
sizes
from
total
27,996
participants.
Using
random-effects
model
it
was
demonstrated
that
small
size
(Fisher’s
Z
=
−
2.4,
95%
CI
[−
0.27.
0.21],
p
<
0.001).
Substantial
heterogeneity
between
studies
observed,
meta-regression
analyses
demonstrating
significant
mean
age
on
the
diurnal
depression.
There
also
potential
publication
bias
as
assessed
by
visual
inspection
funnel
plots
Egger’s
test.
depression
magnitude
heterogenous.
better
understanding
mechanistic
underpinnings
linking
suitably
powered
prospective
allow
causal
inference
are
required.
