Drivers of individual differences in the sleep behaviour of fallow deer neonates

Journal of Animal Ecology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Abstract Inter‐individual differences are necessary for selection to act, while plasticity (intra‐individual variation) may buffer against selection. Sleep is a critical self‐maintenance behaviour but, unlike most behaviours, the causes and consequences of its inter‐ intra‐individual variation in wild animals poorly understood, particularly neonates where sleep plays key role development. We have shown previously that free‐ranging neonate fallow deer ( Dama dama ) differ during first few weeks life. Here, we test whether individual variability organised systematically across population, these associated with chronic stress measured using hair cortisol, or timing birth. Four dimensions (total time, fragmentation, quality, distribution over 24‐h) were quantified state‐of‐the‐art triaxial accelerometers. then used multivariate mixed‐effects model Bayesian framework evaluate covariation between multiple behaviour, quantify relative importance birth, accounting confounding effects environmental conditions age. found birth not changes individuals. While both total time number bouts per day declined age, their rate development covaried, but no other covaried. Our results represent an in‐depth analysis natural sleep, show four aspects architecture free‐living fawns strong independent one another unrelated suggest might emerge later life cortisol be very short transient.

Язык: Английский

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Sleep timing and the circadian clock in mammals: Past, present and the road ahead

Seminars in Cell and Developmental Biology, Год журнала: 2021, Номер 126, С. 3 - 14

Опубликована: Июнь 4, 2021

Язык: Английский

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Goodnight, astrocyte: waking up to astroglial mechanisms in sleep

FEBS Journal, Год журнала: 2022, Номер 290(10), С. 2553 - 2564

Опубликована: Март 10, 2022

Astrocytes mediate many important aspects of neural homeostasis, but until recently, their role in sleep was largely unknown. The situation has dramatically changed the last decade. use transgenic animals, optogenetics, chemogenetics, brain imaging and sophisticated molecular assays led to exciting discoveries. dynamically change activity across sleep–wake cycle may encode need via changes intracellular signalling pathways. also exocytose/secrete sleep‐inducing molecules which modulate activity, architecture regulation. Many these observations have been made mice Drosophila melanogaster , indicating that astroglial mechanisms are evolutionarily conserved. We review recent findings discuss future directions.

Язык: Английский

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Ecological and social pressures interfere with homeostatic sleep regulation in the wild

eLife, Год журнала: 2022, Номер 11

Опубликована: Март 1, 2022

Sleep is fundamental to the health and fitness of all animals. The physiological importance sleep underscored by central role homeostasis in determining investment – following periods deprivation, individuals experience longer more intense bouts. Yet, most research has been conducted highly controlled settings, removed from evolutionarily relevant contexts that may hinder maintenance homeostasis. Using triaxial accelerometry GPS track patterns a group wild baboons ( Papio anubis ), we found ecological social pressures indeed interfere with homeostatic regulation. Baboons sacrificed time spent sleeping when less familiar locations proximity group-mates, regardless how long they had slept prior night or much physically exerted themselves preceding day. Further, did not appear compensate for lost via We collective dynamics characteristic animal groups persist into period, as exhibited synchronized waking throughout night, particularly nearby group-mates. Thus, animals whose depends critically on avoiding predation developing relationships, maintaining be only secondary remaining vigilant risky habitats interacting group-mates during night. Our results highlight studying ecologically contexts, where adaptive function directly reflects complex trade-offs have guided its evolution.

Язык: Английский

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Developing forebrain synapses are uniquely vulnerable to sleep loss

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(44)

Опубликована: Окт. 23, 2024

Sleep is an essential behavior that supports lifelong brain health and cognition. Neuronal synapses are a major target for restorative sleep function locus of dysfunction in response to deprivation (SD). Synapse density highly dynamic during development, becoming stabilized with maturation adulthood, suggesting exerts distinct synaptic functions between development adulthood. Importantly, problems common neurodevelopmental disorders including autism spectrum disorder (ASD). Moreover, early life disruption animal models causes long-lasting changes adult behavior. Divergent plasticity engaged necessarily implies developing will show differential vulnerability SD. To investigate mechanisms SD across we systematically examined the behavioral molecular responses acute juvenile (P21 P28), adolescent (P42 P49), (P70 P100) mice both sexes. Compared adults, juveniles lack robust adaptations SD, precipitating cognitive deficits novel object recognition task. Subcellular fractionation, combined proteome phosphoproteome analysis revealed synapse profoundly vulnerable whereas adults exhibit comparative resilience. juveniles, not older mice, aberrantly drives induction potentiation, synaptogenesis, expression perineuronal nets. Our further reveals as putative node convergence ASD genetic risk. Together, our systematic developmental how impacts key aspects providing insights susceptibility.

Язык: Английский

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Influence of Repeated Exposure to Neonatal Isoflurane on Sleep Architecture and Neuronal Delta and Theta Oscillations in Adolescent Rats

Anesthesia & Analgesia, Год журнала: 2025, Номер unknown

Опубликована: Март 6, 2025

Normal sleep architecture is important for brain development, and we previously demonstrated that a single exposure to isoflurane during the neonatal period did not induce changes in only minimally altered neuronal beta oscillations adolescent rats. Here, hypothesized more clinically relevant scenario of repeated shorter exposures development may have profound effects on wake behavior associated delta theta oscillations, respectively. Male female rat pups were exposed sham anesthesia (30% oxygen) or delivery 2 hours each 3 consecutive days (total 6 hours). The divided into cohorts. In cohort 1, evaluated neurotoxic postanesthesia. 2, electroencephalogram electrodes implanted cortex between postnatal 21-23, was classified as wake, nonrapid eye movement (NREM), rapid-eye (REM) sleep. Electroencephalogram power spectra also measured rats over 72-hour period. Isoflurane (n = 11) increased neuroapoptosis 27. 7 ± 6.5 per mm-2 when compared group (9. 3.0 mm-2, n 12, P < .001) disrupted Specifically, there an increase total time (light + dark period) from 89. 9 14.2 minutes 9) 111. 32.2 experimental 11, .05). Furthermore, fewer transitions 157. 1 43.3 110. 52.5 absolute significantly decreased light NREM average 2217 2016 μV2 8) 791 659 Further, stage 1579 885 690 413 .05) 1390 808 691 421 Exposing repeatedly causes significant neurotoxicity, alters thalamocortical well adolescence. This contrasts with continuous isoflurane, which reported no sleep-wake minimal effect despite similar acute neurotoxicity.

Язык: Английский

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Local versus global sleep organization and the quest to determine sleep function

Neurobiology of Sleep and Circadian Rhythms, Год журнала: 2025, Номер unknown, С. 100117 - 100117

Опубликована: Апрель 1, 2025

Язык: Английский

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Early life sleep in free-living fallow deer, Dama dama: the role of ontogeny, environment and individual differences

Animal Behaviour, Год журнала: 2024, Номер 211, С. 163 - 180

Опубликована: Апрель 11, 2024

An individual's future behaviour and fitness are strongly influenced by early life experience. Within the suite of factors that underpin juvenile development, sleep plays a particularly important role, fulfilling vital physiological cognitive functions. Sleep ontogeny is process which time becomes shorter more consolidated into fewer bouts from in utero development to adulthood; however, how quantity, fragmentation quality develop neonates wild unknown. We investigated this question 19 free-ranging fallow deer fawns, Dama dama, during first 5 weeks life. Specifically, we examined developed, it differed between within individuals, was affected environmental conditions, using accelerometer-derived estimates Bayesian hierarchical modelling approach. showed duration rapidly decreased became consolidated, quickly approaching an adult-like condition. Moreover, fawns exhibited consistent individual differences quality, as well rate at developed. Finally, conditions affecting thermoregulation mediated behaviour; reduced lower on warmer days, further compromised humid but higher with greater rainfall. While partially shaped environment, our study reveals previously unknown present birth, development. suggest such may represent pace-of-life syndromes have consequences for later

Язык: Английский

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The Complex Relationship between Sleep and Cognitive Reserve: A Narrative Review Based on Human Studies

Brain Sciences, Год журнала: 2024, Номер 14(7), С. 654 - 654

Опубликована: Июнь 27, 2024

Sleep and brain/cognitive/neural reserve significantly impact well-being cognition throughout life. This review aims to explore the intricate relationship between such factors, with reference their effects on human cognitive functions. The specific goal is understand bidirectional influence that sleep exert each other. Up 6 February 2024, a methodical search of literature was conducted using PubMed database terms related brain, or neural reserve, healthy disturbed sleep. Based inclusion criteria, 11 articles were selected analyzed for this review. focus almost exclusively no explicit connection brain reserve. results evidence sleep’s role as builder reserve’s moderator in physiological pathological In conclusion, findings present support notion both are critical factors functioning. Deepening comprehension interactions them essential devising strategies enhance health resilience against age- pathology-related conditions.

Язык: Английский

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Shank3 influences mammalian sleep development

Journal of Neuroscience Research, Год журнала: 2022, Номер 100(12), С. 2174 - 2186

Опубликована: Сен. 2, 2022

Abstract Sleep problems are prevalent in autism spectrum disorder (ASD), can be observed before diagnosis, and associated with increased restricted repetitive behaviors. Therefore, sleep abnormalities may a core feature of the disorder, but developmental trajectory remains unknown. Animal models provide unique opportunity to understand ontogenesis ASD. Previously we showed that adult mice truncation high‐confidence ASD gene Shank3 (Shank3 ∆C ) recapitulate clinical phenotype. In this study used longitudinal electro‐encephalographic (EEG) recordings define, for first time, changes from weaning young adulthood an mouse model. We show male less overall throughout their lifespan, have rapid eye movement (REM) early life despite significantly reduced non‐rapid (NREM) sleep, abnormal responses pressure emerge during specific period. demonstrate ability fall asleep quickly response loss develops normally between 24 30 days mice. However, mutants unable reduce latency after periods prolonged waking maintain same regardless age. This phenomenon seems independent homeostatic NREM slow‐wave dynamics. Overall, our recapitulates both preclinical studies showing is consistently suggests falling reflect development arousal mechanisms.

Язык: Английский

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