Journal of Materials Chemistry B, Год журнала: 2024, Номер unknown
Опубликована: Дек. 16, 2024
Ultrasmall metal nanoclusters (NCs, <2 nm) have emerged as a novel class of photoluminescent bioimaging probes. This review article examines how NC-based probe is designed with desired functionalities for applications.
Язык: Английский
Pharmaceutics, Год журнала: 2024, Номер 16(10), С. 1332 - 1332
Опубликована: Окт. 16, 2024
The remarkable versatility of gold nanoparticles (AuNPs) makes them innovative agents across various fields, including drug delivery, biosensing, catalysis, bioimaging, and vaccine development. This paper provides a detailed review the important role AuNPs in delivery therapeutics. We begin by exploring traditional systems (DDS), highlighting revolutionizing techniques. then describe unique intriguing properties that make exceptional for delivery. Their shapes, functionalization, drug-loading bonds, targeting mechanisms, release therapeutic effects, cellular uptake methods are discussed, along with relevant examples from literature. Lastly, we present applications medical domains, cancer, cardiovascular diseases, ocular diabetes, focus on vitro vivo cancer research.
Язык: Английский
Процитировано
24
Advanced Healthcare Materials, Год журнала: 2024, Номер 14(4)
Опубликована: Ноя. 6, 2024
Cancer remains one of the most challenging health issues globally, demanding innovative therapeutic approaches for effective treatment. Nanoparticles, particularly those composed gold, silver, and iron oxide, have emerged as promising candidates changing cancer therapy. This comprehensive review demonstrates landscape nanoparticle-based oncological interventions, focusing on remarkable advancements potentials oxide nanoparticles. Gold nanoparticles garnered significant attention their exceptional biocompatibility, tunable surface chemistry, distinctive optical properties, rendering them ideal various diagnostic strategies. Silver nanoparticles, renowned antimicrobial exhibit potential in therapy through multiple mechanisms, including apoptosis induction, angiogenesis inhibition, drug delivery enhancement. With magnetic properties offer unique diagnosis targeted opportunities. critically examines recent synthesis, functionalization, biomedical applications these Moreover, challenges are discussed, toxicity concerns, immunogenicity, translational barriers, ongoing efforts to overcome hurdles highlighted. Finally, insights into future directions regulatory considerations, provided aiming accelerate translation technologies from bench bedside.
Язык: Английский
Процитировано
15
Small, Год журнала: 2024, Номер 20(45)
Опубликована: Июль 16, 2024
The tracking of nanomedicines in their concentration and location inside living systems has a pivotal effect on the understanding biological processes, early-stage diagnosis, therapeutic monitoring diseases. Nanoscale metal-organic frameworks (nano MOFs) possess high surface areas, definite structure, regulated optical properties, rich functionalized sites, good biocompatibility that allow them to excel wide range biomedical applications. Controllable syntheses functionalization endow nano MOFs with better properties as imaging agents sensing units for diagnosis treatment This minireview summarizes tunable synthesis strategies controllable size, shape, luminescent performance, pinpoints recent advanced applications elements bioimaging biosensing. current limitations future development directions MOF-contained materials biosensing are also discussed, aiming expand MOF-based nanomedicine facilitate production or clinical translation.
Язык: Английский
Процитировано
10
Open Life Sciences, Год журнала: 2024, Номер 19(1)
Опубликована: Янв. 1, 2024
Abstract Gold nanoparticles (AuNPs) have unique features that might lead to the development of a new class diabetic medicines. AuNPs were biosynthesized utilizing sodium-alginate. UV-Vis-spectroscopy, Fourier transforms infrared, field emission scanning electron microscopy (FESEM), and energy dispersive X-ray used examine particles. The potential for improving diabetes condition was examined along with swimming in rats. FESEM image revealed spherical morphology an average particle size 106.6 ± 20.8 nm. In group, serum glucose, blood urea nitrogen (BUN), creatinine, cholesterol, triglyceride (TG) levels significantly higher than control group. Low-density lipoprotein (LDL) high-density (HDL) lower group compared Malondialdehyde (MDA) also D However, groups treated gold, these parameters improved. Specifically, serum-glucose, BUN, TG reduced, while LDL decreased + HDL increased MDA groups, other antioxidants improved Catalase gold It can be concluded both decrease complications.
Язык: Английский
Процитировано
7
Nano Research, Год журнала: 2024, Номер 17(11), С. 9490 - 9497
Опубликована: Авг. 21, 2024
Язык: Английский
Процитировано
7
Molecules, Год журнала: 2024, Номер 29(8), С. 1848 - 1848
Опубликована: Апрель 18, 2024
In recent years, the frequency of strokes has been on rise year by and become second leading cause death around world, which is characterized a high mortality rate, recurrence disability rate. Ischemic account for large percentage strokes. A reperfusion injury in ischemic complex cascade oxidative stress, neuroinflammation, immune infiltration, mitochondrial damage. Conventional treatments are ineffective, presence blood–brain barrier (BBB) leads to inefficient drug delivery utilization, so researchers turning their attention nano-drug systems. Functionalized systems have widely studied applied study cerebral diseases due favorable biocompatibility, efficiency, strong specificity, specific targeting ability. this paper, we briefly describe pathological process injuries focus therapeutic research progress strokes, aiming provide certain references understand (NDDSs).
Язык: Английский
Процитировано
3
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Окт. 10, 2024
The therapeutic efficacy of photothermal therapy (PTT) under mild temperatures (<45 °C) is hindered as cancer cells can activate heat shock proteins (HSPs) to mend fever-type cellular damage swiftly. previous attempt fabricated first-generation nanobombs (nanobomb1G) by self-assembly polymeric NIR-II AIEgens and carbon monoxide (CO) carrier polymer mPEG(CO) inhibit the expression HSPs after intratumor injection. A new generation nanobomb (Stealth NanoBomb (SNB)) developed self-assembling small molecular with CO PLGA(CO) coated PEG-lipid. This design allows for intravenous administration, enabling SNB circulate safely in bloodstream selectively target cells. Upon accumulation tumors, releases effectively suppress HSP expression, enhancing mild-temperature PTT. Compared generation, offers a safer, more stable, efficient gas/drug co-delivery system treatment. work represents significant advancement PTT, providing promising strategy enhanced antitumor reduced systemic toxicity.
Язык: Английский
Процитировано
3
Exploration, Год журнала: 2025, Номер unknown
Опубликована: Фев. 6, 2025
ABSTRACT Gold nanomaterials have been used in the diagnosis and treatment of different tumors due to their unique physical chemical properties. Among them, gold nanoparticles with stimuli‐responsive aggregation functions attracted extensive attention because they can meet needs tumor at stages through structural changes. However, how effectively modify achieve transformation for specific stimuli, role corresponding improving effect still lack systematic summary. In this review, we comprehensively summarized current strategies inducing its advances treatment.
Язык: Английский
Процитировано
0
In Vitro Cellular & Developmental Biology - Plant, Год журнала: 2025, Номер unknown
Опубликована: Апрель 17, 2025
Язык: Английский
Процитировано
0
Deleted Journal, Год журнала: 2025, Номер 24(1)
Опубликована: Апрель 14, 2025
Background: Liver cancer is increasing in different parts of the world and fourth leading cause death globally. Objectives: The present study aims to synthesize analyze characterization gold nanoparticles (AuNPs) synthesized by Cichorium intybus extract evaluate their antioxidant cellular toxicity activity against liver cells (HepG2). Methods: AuNPs were characterized using X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), fourier-transform infrared spectroscopy (FTIR). was assessed DPPH test, cytotoxicity analyzed MTT method. Results: results indicate that are crystalline materials with a particle size less than 100 nm, mean 23.94 nm. FTIR reveals presence biochemical groups act as reducing factors. demonstrate increases concentration, 87% inhibition free radical scavenging observed at 250 µg/mL. Cell cell lines (HepG2) demonstrated significant time- dose-dependent manner. percentage viability concentration 1000 µg/ml after 24, 48, 72 hours determined be 45%, 51%, 22%, respectively. Conclusions: revealed simple cost-effective environmentally friendly method could employed from food pharmaceutical industries.
Язык: Английский
Процитировано
0