Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 16, 2024
Ultrasmall
metal
nanoclusters
(NCs,
<2
nm)
have
emerged
as
a
novel
class
of
photoluminescent
bioimaging
probes.
This
review
article
examines
how
NC-based
probe
is
designed
with
desired
functionalities
for
applications.
Pharmaceutics,
Год журнала:
2024,
Номер
16(10), С. 1332 - 1332
Опубликована: Окт. 16, 2024
The
remarkable
versatility
of
gold
nanoparticles
(AuNPs)
makes
them
innovative
agents
across
various
fields,
including
drug
delivery,
biosensing,
catalysis,
bioimaging,
and
vaccine
development.
This
paper
provides
a
detailed
review
the
important
role
AuNPs
in
delivery
therapeutics.
We
begin
by
exploring
traditional
systems
(DDS),
highlighting
revolutionizing
techniques.
then
describe
unique
intriguing
properties
that
make
exceptional
for
delivery.
Their
shapes,
functionalization,
drug-loading
bonds,
targeting
mechanisms,
release
therapeutic
effects,
cellular
uptake
methods
are
discussed,
along
with
relevant
examples
from
literature.
Lastly,
we
present
applications
medical
domains,
cancer,
cardiovascular
diseases,
ocular
diabetes,
focus
on
vitro
vivo
cancer
research.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
14(4)
Опубликована: Ноя. 6, 2024
Cancer
remains
one
of
the
most
challenging
health
issues
globally,
demanding
innovative
therapeutic
approaches
for
effective
treatment.
Nanoparticles,
particularly
those
composed
gold,
silver,
and
iron
oxide,
have
emerged
as
promising
candidates
changing
cancer
therapy.
This
comprehensive
review
demonstrates
landscape
nanoparticle-based
oncological
interventions,
focusing
on
remarkable
advancements
potentials
oxide
nanoparticles.
Gold
nanoparticles
garnered
significant
attention
their
exceptional
biocompatibility,
tunable
surface
chemistry,
distinctive
optical
properties,
rendering
them
ideal
various
diagnostic
strategies.
Silver
nanoparticles,
renowned
antimicrobial
exhibit
potential
in
therapy
through
multiple
mechanisms,
including
apoptosis
induction,
angiogenesis
inhibition,
drug
delivery
enhancement.
With
magnetic
properties
offer
unique
diagnosis
targeted
opportunities.
critically
examines
recent
synthesis,
functionalization,
biomedical
applications
these
Moreover,
challenges
are
discussed,
toxicity
concerns,
immunogenicity,
translational
barriers,
ongoing
efforts
to
overcome
hurdles
highlighted.
Finally,
insights
into
future
directions
regulatory
considerations,
provided
aiming
accelerate
translation
technologies
from
bench
bedside.
The
tracking
of
nanomedicines
in
their
concentration
and
location
inside
living
systems
has
a
pivotal
effect
on
the
understanding
biological
processes,
early-stage
diagnosis,
therapeutic
monitoring
diseases.
Nanoscale
metal-organic
frameworks
(nano
MOFs)
possess
high
surface
areas,
definite
structure,
regulated
optical
properties,
rich
functionalized
sites,
good
biocompatibility
that
allow
them
to
excel
wide
range
biomedical
applications.
Controllable
syntheses
functionalization
endow
nano
MOFs
with
better
properties
as
imaging
agents
sensing
units
for
diagnosis
treatment
This
minireview
summarizes
tunable
synthesis
strategies
controllable
size,
shape,
luminescent
performance,
pinpoints
recent
advanced
applications
elements
bioimaging
biosensing.
current
limitations
future
development
directions
MOF-contained
materials
biosensing
are
also
discussed,
aiming
expand
MOF-based
nanomedicine
facilitate
production
or
clinical
translation.
Open Life Sciences,
Год журнала:
2024,
Номер
19(1)
Опубликована: Янв. 1, 2024
Abstract
Gold
nanoparticles
(AuNPs)
have
unique
features
that
might
lead
to
the
development
of
a
new
class
diabetic
medicines.
AuNPs
were
biosynthesized
utilizing
sodium-alginate.
UV-Vis-spectroscopy,
Fourier
transforms
infrared,
field
emission
scanning
electron
microscopy
(FESEM),
and
energy
dispersive
X-ray
used
examine
particles.
The
potential
for
improving
diabetes
condition
was
examined
along
with
swimming
in
rats.
FESEM
image
revealed
spherical
morphology
an
average
particle
size
106.6
±
20.8
nm.
In
group,
serum
glucose,
blood
urea
nitrogen
(BUN),
creatinine,
cholesterol,
triglyceride
(TG)
levels
significantly
higher
than
control
group.
Low-density
lipoprotein
(LDL)
high-density
(HDL)
lower
group
compared
Malondialdehyde
(MDA)
also
D
However,
groups
treated
gold,
these
parameters
improved.
Specifically,
serum-glucose,
BUN,
TG
reduced,
while
LDL
decreased
+
HDL
increased
MDA
groups,
other
antioxidants
improved
Catalase
gold
It
can
be
concluded
both
decrease
complications.
Molecules,
Год журнала:
2024,
Номер
29(8), С. 1848 - 1848
Опубликована: Апрель 18, 2024
In
recent
years,
the
frequency
of
strokes
has
been
on
rise
year
by
and
become
second
leading
cause
death
around
world,
which
is
characterized
a
high
mortality
rate,
recurrence
disability
rate.
Ischemic
account
for
large
percentage
strokes.
A
reperfusion
injury
in
ischemic
complex
cascade
oxidative
stress,
neuroinflammation,
immune
infiltration,
mitochondrial
damage.
Conventional
treatments
are
ineffective,
presence
blood–brain
barrier
(BBB)
leads
to
inefficient
drug
delivery
utilization,
so
researchers
turning
their
attention
nano-drug
systems.
Functionalized
systems
have
widely
studied
applied
study
cerebral
diseases
due
favorable
biocompatibility,
efficiency,
strong
specificity,
specific
targeting
ability.
this
paper,
we
briefly
describe
pathological
process
injuries
focus
therapeutic
research
progress
strokes,
aiming
provide
certain
references
understand
(NDDSs).
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 10, 2024
The
therapeutic
efficacy
of
photothermal
therapy
(PTT)
under
mild
temperatures
(<45
°C)
is
hindered
as
cancer
cells
can
activate
heat
shock
proteins
(HSPs)
to
mend
fever-type
cellular
damage
swiftly.
previous
attempt
fabricated
first-generation
nanobombs
(nanobomb1G)
by
self-assembly
polymeric
NIR-II
AIEgens
and
carbon
monoxide
(CO)
carrier
polymer
mPEG(CO)
inhibit
the
expression
HSPs
after
intratumor
injection.
A
new
generation
nanobomb
(Stealth
NanoBomb
(SNB))
developed
self-assembling
small
molecular
with
CO
PLGA(CO)
coated
PEG-lipid.
This
design
allows
for
intravenous
administration,
enabling
SNB
circulate
safely
in
bloodstream
selectively
target
cells.
Upon
accumulation
tumors,
releases
effectively
suppress
HSP
expression,
enhancing
mild-temperature
PTT.
Compared
generation,
offers
a
safer,
more
stable,
efficient
gas/drug
co-delivery
system
treatment.
work
represents
significant
advancement
PTT,
providing
promising
strategy
enhanced
antitumor
reduced
systemic
toxicity.
ABSTRACT
Gold
nanomaterials
have
been
used
in
the
diagnosis
and
treatment
of
different
tumors
due
to
their
unique
physical
chemical
properties.
Among
them,
gold
nanoparticles
with
stimuli‐responsive
aggregation
functions
attracted
extensive
attention
because
they
can
meet
needs
tumor
at
stages
through
structural
changes.
However,
how
effectively
modify
achieve
transformation
for
specific
stimuli,
role
corresponding
improving
effect
still
lack
systematic
summary.
In
this
review,
we
comprehensively
summarized
current
strategies
inducing
its
advances
treatment.
Background:
Liver
cancer
is
increasing
in
different
parts
of
the
world
and
fourth
leading
cause
death
globally.
Objectives:
The
present
study
aims
to
synthesize
analyze
characterization
gold
nanoparticles
(AuNPs)
synthesized
by
Cichorium
intybus
extract
evaluate
their
antioxidant
cellular
toxicity
activity
against
liver
cells
(HepG2).
Methods:
AuNPs
were
characterized
using
X-ray
diffraction
(XRD),
field
emission
scanning
electron
microscopy
(FESEM),
fourier-transform
infrared
spectroscopy
(FTIR).
was
assessed
DPPH
test,
cytotoxicity
analyzed
MTT
method.
Results:
results
indicate
that
are
crystalline
materials
with
a
particle
size
less
than
100
nm,
mean
23.94
nm.
FTIR
reveals
presence
biochemical
groups
act
as
reducing
factors.
demonstrate
increases
concentration,
87%
inhibition
free
radical
scavenging
observed
at
250
µg/mL.
Cell
cell
lines
(HepG2)
demonstrated
significant
time-
dose-dependent
manner.
percentage
viability
concentration
1000
µg/ml
after
24,
48,
72
hours
determined
be
45%,
51%,
22%,
respectively.
Conclusions:
revealed
simple
cost-effective
environmentally
friendly
method
could
employed
from
food
pharmaceutical
industries.