Coordination Chemistry Reviews, Год журнала: 2025, Номер 541, С. 216839 - 216839
Опубликована: Май 31, 2025
Язык: Английский
Computer Methods in Biomechanics & Biomedical Engineering, Год журнала: 2025, Номер unknown, С. 1 - 19
Опубликована: Март 20, 2025
Drug delivered from the microneedle (MN) tip diffuses across viscoelastic skin before entering blood compartment and being absorbed. Reversible uptake kinetics between tissue compartments, reversible specific saturable binding with its receptors, endocytosis are given due attention. Simulations predict that, unlike thinning, viscoelasticity a higher Young's modulus value, as in an older person, inhibit verapamil diffusion within skin, metabolism stabilises concentrations compartments. Simultaneously, irreversible improve drug compartment, facilitating receptor-mediated endocytosis. The results also that internalised increases time at slower internalisation rates; however, rates, it attains peak value gradually diminishing. Furthermore, rate of lysosomal degradation escalates, concentration diminishes shifts upward. A comprehensive sensitivity analysis has been performed because uncertainty about several crucial parameters. Our findings align well existing literature.
Язык: Английский
Процитировано
0
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Апрель 8, 2025
Acupuncture, rooted in Traditional Chinese Medicine (TCM), serves as a complementary and alternative therapeutic modality that involves the insertion of needles into specific body points to stimulate treat variety conditions. Over time, acupuncture has garnered global acceptance, progressively addressing an increasing spectrum medical disorders. The integration nanotechnology holds considerable potential improve drug delivery efficacy broaden scope acupuncture's applications, providing novel opportunities for investigating underlying principles meridians acupoints. A bibliometric analysis application over past two decades (2004-2024) highlights emerging research trends focal field. This article provides overview history, biological mechanisms, preparation methods, clinical status nanoacupuncture, with focus on analyzing applications nanoacupuncture technology. Nanotechnology enables visualization imaging acupoints, facilitating deeper understanding physiological mechanisms behind effects. Modified incorporating can serve dual purposes: functioning sensors real-time monitoring various parameters, thereby supporting disease diagnosis enhancing through specialized interventions. Furthermore, nanotechnology-enhanced act platforms targeted working tandem responsive nanoparticles treatment. Despite its promising applicability, faces inherent limitations challenges must be addressed.
Язык: Английский
Процитировано
0
International Journal of Pharmaceutics, Год журнала: 2025, Номер 677, С. 125640 - 125640
Опубликована: Апрель 24, 2025
Multiple chemotherapeutic strategies have been developed to tackle the complexity of cancer. Still, outcome regimens remains impaired by drugs' weak solubility, unspecific biodistribution and poor tumor accumulation after systemic administration. Such constraints triggered development nanomaterials encapsulate deliver anticancer drugs. In fact, loading drugs into nanoparticles can overcome most solubility concerns. However, ability systemically administered drug-loaded reach site has vastly overestimated, limiting their clinical translation. The nanomaterials' administration issues propelled hydrogels capable performing direct/local delivery site. use these macroscale systems mediate a tumor-confined drugs/drugs-loaded grants an improved therapeutic efficacy and, simultaneously, reduction side effects. manufacture requires careful selection tailoring specific polymers/materials as well choice appropriate physical and/or chemical crosslinking interactions. Depending on route assembling process, matrices be classified injectable in situ forming hydrogels, shear-thinning/self-healing implantable each type bringing plethora advantages for intended biomedical application. This review provides reader with insight application nanomaterials.
Язык: Английский
Процитировано
0
Polymers, Год журнала: 2025, Номер 17(10), С. 1351 - 1351
Опубликована: Май 15, 2025
Microneedles (MNs) hold significant potential for applications in transdermal drug delivery and biosensing. However, when traditional 3D printing technology is used their manufacture, a substantial deviation output size occurs. The effects of various parameters on the morphology MNs produced through microscale remain unclear. This study investigated relationship between design fabrication acrylic resin forms via projection microstereolithography (PµSL) system. Modifying shape array configurations elucidates causes proposes control strategy. particularly prototyping mold manufacturing relevant fields. indicates that layer thickness 10 µm optimally balances efficiency clinical conversion requirements. Additionally, an exposure intensity 65 mW/cm2 achieves both high fidelity appropriate base size. angle significantly influences mechanical properties MNs. diameter aspect ratio solid correlate with dimensional stability. Clinically, conical or quadrilateral defined are recommended. A critical spacing (≥40 µm) optimal arrangement MN arrays were established. specific vertical hollow ensure precision micropore wall thickness. approach offers theoretical insights process essential high-precision, customizable engineering design.
Язык: Английский
Процитировано
0
Coordination Chemistry Reviews, Год журнала: 2025, Номер 541, С. 216839 - 216839
Опубликована: Май 31, 2025
Язык: Английский
Процитировано
0