A Mitochondria‐Targeted Biomimetic Nanocarrier Improves Oxygen Metabolism and Potentiates Chemo‐Sonodynamic Antitumor Therapy DOI
Fang Zhang,

Yong‐Guo Hu,

Xiao‐Ling Lei

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 30, 2025

Abstract Sonodynamic therapy (SDT) exhibits high tissue penetration and negligible radiation damage to normal tissue, but it hampered by the limited oxygen in tumor, which can be potentiated via improving metabolism increasing utilization efficiency. Herein, a multifunctional biomimetic nanocarrier (VI@R‐T) is fabricated encapsulating vanadium‐based nanozyme (VO x ) with dual enzyme activity sonosensitizer indocyanine green (ICG) into mitochondria‐targeted erythrocyte vesicle. The targeted mitochondria, where red blood cell membrane catalyzed endogenous H 2 O increase content for alleviating hypoxia. Meanwhile, NADH oxidase (NOX) affecting nicotinamide adenine dinucleotide/flavin dinucleotide (NADH/FAD) balance cellular oxidative phosphorylation, impairs mitochondrial electron transport chain reduces intracellular consumption, thereby significantly tumor efficacy of SDT. In addition, also shows peroxide‐like microenvironment (TME), generates highly toxichydroxyl radical (OH) ROS‐amplifying stress. Deep‐hypothermia 2D/3D autofluorescence imaging monitored effectively disrupt NADH/FAD tumor. This work provides anew approach designing ROS‐based nanomedical platform hypoxia relief.

Язык: Английский

Metal-based nanomedicine systems for the diagnosis and treatment of colorectal cancer: Current advances and future perspectives DOI

Jie Gou,

Lu Chen,

Tianyu Liu

и другие.

Materials Today Chemistry, Год журнала: 2025, Номер 45, С. 102702 - 102702

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Ultrasound-responsive nanoweapons: covalent organic frameworks for cancer sonodynamic therapy DOI
Yu Shrike Zhang, Chunyuan Hou, Bin Zhu

и другие.

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Sonodynamic therapy (SDT), characterized by its non-invasiveness, low toxicity, and deep tissue penetration, has emerged as a promising therapeutic modality for anticancer treatments. Recently, covalent organic frameworks (COFs) have garnered significant attention in the SDT realm powerful versatile toolbox. Notably, COF-based achieved many encouraging outcomes owing to remarkable potential of COFs, volume related research experienced continuous growth. Therefore, we strive provide timely comprehensive review that thoroughly summarizes advancements SDT. This begins with concise yet summary ultrasonic cavitation sonodynamic effects, elucidating fundamental principles mechanisms Subsequently, it delves into chemistry examining intricate structure designs, various types linkages, diverse synthetic methods. The primary focus this is summarize sonosensitizers, including construction strategies product properties. More importantly, role COFs combined therapies described detail, aiming highlight advantages COF-enhanced synergistic Finally, points out current challenges future opportunities rapidly evolving field. Overall, deliberations overviews sonosensitizers are expected facilitate advancements, leading early-stage clinical benefits patients.

Язык: Английский

Процитировано

0
Innovative immunosonogen nanoplatform combining sonodynamic oxygenation and immunomodulation for superior cancer therapy DOI
Jiali Tang, Yanlu Chen, Hao Lai

и другие.

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 163582 - 163582

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
A Mitochondria‐Targeted Biomimetic Nanocarrier Improves Oxygen Metabolism and Potentiates Chemo‐Sonodynamic Antitumor Therapy DOI
Fang Zhang,

Yong‐Guo Hu,

Xiao‐Ling Lei

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 30, 2025

Abstract Sonodynamic therapy (SDT) exhibits high tissue penetration and negligible radiation damage to normal tissue, but it hampered by the limited oxygen in tumor, which can be potentiated via improving metabolism increasing utilization efficiency. Herein, a multifunctional biomimetic nanocarrier (VI@R‐T) is fabricated encapsulating vanadium‐based nanozyme (VO x ) with dual enzyme activity sonosensitizer indocyanine green (ICG) into mitochondria‐targeted erythrocyte vesicle. The targeted mitochondria, where red blood cell membrane catalyzed endogenous H 2 O increase content for alleviating hypoxia. Meanwhile, NADH oxidase (NOX) affecting nicotinamide adenine dinucleotide/flavin dinucleotide (NADH/FAD) balance cellular oxidative phosphorylation, impairs mitochondrial electron transport chain reduces intracellular consumption, thereby significantly tumor efficacy of SDT. In addition, also shows peroxide‐like microenvironment (TME), generates highly toxichydroxyl radical (OH) ROS‐amplifying stress. Deep‐hypothermia 2D/3D autofluorescence imaging monitored effectively disrupt NADH/FAD tumor. This work provides anew approach designing ROS‐based nanomedical platform hypoxia relief.

Язык: Английский

Процитировано

0