Science China Materials, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 22, 2024
Язык: Английский
Science China Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 20, 2025
Язык: Английский
Процитировано
2
Nanomaterials, Год журнала: 2024, Номер 14(3), С. 296 - 296
Опубликована: Янв. 31, 2024
Injectable colloidal solutions of lanthanide oxides (nanoparticles between 10 and 100 nm in size) have demonstrated high biocompatibility no toxicity when the nanoparticulate units are functionalized with specific biomolecules that molecularly target various proteins tumor microenvironment. Among successfully targeted by nanoparticles folic receptors, fibroblast activation protein (FAP), gastrin-releasing peptide receptor (GRP-R), prostate-specific membrane antigen (PSMA), integrins associated neovasculature. Lutetium, samarium, europium, holmium, terbium, either as oxide or doped ions, their theranostic potential through ability to generate molecular images magnetic resonance, nuclear, optical, computed tomography imaging. Likewise, photodynamic therapy, radiotherapy (neutron-activated nanoparticles), drug delivery guidance, image-guided therapy some examples therapeutic applications. This review provides an overview cancer theranostics based on coated peptides, ligands, targeting
Язык: Английский
Процитировано
11
MedComm, Год журнала: 2024, Номер 5(10)
Опубликована: Сен. 17, 2024
Liver cirrhosis is the end-stage of chronic liver disease, characterized by inflammation, necrosis, advanced fibrosis, and regenerative nodule formation. Long-term inflammation can cause continuous damage to tissues hepatocytes, along with increased vascular tone portal hypertension. Among them, fibrosis necessary stage essential feature cirrhosis, effective antifibrosis strategies are commonly considered key treating cirrhosis. Although different therapeutic aimed at reversing or preventing have been developed, effects not be more satisfactory. In this review, we discussed abnormal changes in microenvironment that contribute progression highlighted importance recent strategies, including lifestyle improvement, small molecular agents, traditional Chinese medicine, stem cells, extracellular vesicles, gut remediation, regulate Meanwhile, for nanoparticles discussed, as their possible underlying broad application prospects ameliorating Finally, also reviewed major challenges opportunities nanomedicine‒biological environment interactions. We hope review will provide insights into pathogenesis mechanisms thus facilitating new methods, drug discovery, better treatment
Язык: Английский
Процитировано
6
Small, Год журнала: 2024, Номер 20(30)
Опубликована: Фев. 28, 2024
Abstract The advanced design of rare‐earth‐doped (RE‐doped) fluoride nanoparticles has expanded their applications ranging from anticounterfeiting luminescence and contactless temperature measurement to photodynamic therapy. Several recent studies have focused on developing rare morphologies RE‐doped nanoparticles. Distinct physical materials set them apart contemporary Every unusual structure holds the potential dramatically improve performance nanoparticles, resulting in a remarkable revolution wide range applications. This comprehensive review serves as guide offering insights into various uniquely structured including hollow, dumbbell‐shaped, peasecod‐like forms. It aims cater both novices experts interested exploring morphological transformations Discovering new energy transfer pathways enhancing optical application been long‐term challenges for which solutions can be found old papers. In future, nanoparticle morphology is expected involve more refined microphysical methods chemically‐induced syntheses. Targeted modification aggregation shapes provide advantages different structures enhance universality
Язык: Английский
Процитировано
5
Advanced Functional Materials, Год журнала: 2024, Номер 34(23)
Опубликована: Фев. 14, 2024
Abstract Neural imaging plays a crucial role in understanding the structure and function of living body. While near‐infrared‐II (NIR‐II) techniques have emerged as potential tools for non‐invasive high‐resolution neural activity, there been rare relevant reports on vivo imaging. This study presents development biodegradable NIR‐II rare‐earth nanoprobes novel contrast agent enhanced The exhibit excellent long wavelength emission, high quantum yield, tunable biodegradation time vivo. work demonstrates effectiveness these enhancing depth resolution mouse model thereby facilitating better nervous system. Furthermore, their biodegradability ensures minimal long‐term toxicity allows repeatedly monitoring damaged nerves during recovery or deterioration process. results highlight advancing deeper insights into neuroscience research clinical diagnostics.
Язык: Английский
Процитировано
4
Advanced Optical Materials, Год журнала: 2024, Номер 12(18)
Опубликована: Март 18, 2024
Abstract Alkaline zirconium fluorides (A x Zr y F x+y , A = Li, Na, and K), featuring unique crystallographic structures, have recently emerged as a class of attractive hosts for fabricating lanthanide (Ln 3+ )‐doped upconversion nanocrystals (UCNCs) that exhibited distinct morphology, luminescence (UCL) performance, physicochemical property. In this paper, the first time controlled preparation Yb /Er ‐doped UCNCs is reported based on trigonal Cs 2 ZrF 6 host, leading to tunable morphology size resulting by varying reaction temperature time. By further incorporating Na + ions into crystal lattice, sub‐10 nm /Na tridoped with highly improved crystallinity thus greatly enhanced UCL intensity are obtained. Moreover, these display abnormal thermal enhancement over range from 333 493 K, enabling fabrication supersensitive luminescent nanothermometers sensing. Based ratio two nonthermally coupled levels (i.e., 4 9/2 H 11/2 ) Er as‐prepared :Yb/Er/Na exhibit an extremely large absolute sensitivity 177.3% K −1 considerably high relative 1.52% at K. These results unambiguously demonstrate suitable host material preparing small‐sized Ln nanothermometer high‐performance ratiometric
Язык: Английский
Процитировано
4
Nano Letters, Год журнала: 2024, Номер 24(9), С. 2876 - 2884
Опубликована: Фев. 22, 2024
Upconversion (UC)/downconversion (DC)-luminescent lanthanide-doped nanocrystals (LDNCs) with near-infrared (NIR, 650–1700 nm) excitation have been gaining increasing popularity in bioimaging. However, conventional NIR-excited LDNCs cannot be degraded and eliminated eventually vivo owing to intrinsic "rigid" lattices, thus constraining clinical applications. A biodegradability-tunable heterogeneous core–shell–shell luminescent LDNC of Na3HfF7:Yb,Er@Na3ZrF7:Yb,Er@CaF2:Yb,Zr (abbreviated as HZC) was developed modified oxidized sodium alginate (OSA) for multimode The dynamic "soft" lattice-Na3Hf(Zr)F7 host the varying Zr4+ doping content outmoster CaF2 shell endowed HZC tunable degradability. Through elaborated coating, Yb3+/Er3+-coupled UC red green DC second (NIR-II) emissions were, respectively, enhanced by 31.23-, 150.60-, 19.42-fold when compared core nanocrystals. generated computed tomography (CT) imaging contrast effects, enabling NIR-II/CT/UC trimodal imaging. OSA modification not only ensured exemplary biocompatibility but also enabled tumor-specific diagnosis. findings would benefit translation LDNCs.
Язык: Английский
Процитировано
4
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Май 24, 2025
In this work, we report the synthesis of Na3ZrF7 nanoparticles as an appealing host matrix for lanthanide ions both upconversion (bidoped, sensitizer-activator Yb3+-Er3+ in vis and NIR-I regions) downshifting (tridoped, sensitizer-activator-activator Yb3+-Ho3+-Er3+ NIR-II region) ratiometric luminescence nanothermometry physiological temperature range (293.15-323.15 K). We explored three different routes to reveal most favorable synthetic approach bioapplication purposes well investigated characterized temperature-dependent photoluminescence (PL) properties obtained nanoparticles. Furthermore, a biocompatible DSPE-PEG2000-based layer was incorporated render water-dispersible subsequently evaluate their degradation-induced vitro toxicity toward HeLa Normal Human Dermal Fibroblast (NHDF) cells. Additional tests were conducted preliminarily cellular uptake future biological applications. show that conditions solvent environment influence morphology, crystalline phase, PL emission profiles. To best our knowledge, is first effort at extensive systematic nanosized core-only core-shell(s) materials luminescent thermometers reported temperature-sensing performance via (NIR-I-to-vis) (NIR-I-to-NIR-II) mechanisms material, cyclohexane aqueous environment.
Язык: Английский
Процитировано
0
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Ноя. 10, 2024
Lanthanide-based nanomaterials offer a promising alternative for cancer therapy because of their selectivity and effectiveness, which can be modified predicted by leveraging the improved accuracy enhanced decision-making machine learning (ML) modeling.
Язык: Английский
Процитировано
3
Ceramics International, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
2