Analytical Methods,
Год журнала:
2024,
Номер
17(3), С. 533 - 538
Опубликована: Дек. 10, 2024
The
superoxide
anion
(O2˙-)
is
a
vital
reactive
oxygen
species
(ROS)
and
participates
in
various
physiological
pathological
processes
organisms.
outbreak
of
O2˙-
the
endoplasmic
reticulum
(ER)
believed
to
be
closely
related
many
inflammatory
diseases.
In
this
work,
turn-on
type
ER-targeting
fluorescent
probe
ERO
was
rationally
designed
for
sensitive
selective
detection
O2˙-.
minimum
limit
concentration
about
3.3
×
10-7
M
aqueous
solution.
More
importantly,
has
minimal
biological
toxicity
can
effectively
target
ER
detect
macrophage
cells.
Resveratrol
natural
drug
anti-inflammatory
effects.
Through
fluorescence
monitoring
ERO,
it
found
that
there
an
acute
spondylitis
mice
resveratrol
reversed
increase.
Thus,
potential
become
favorable
diagnostic
tool
visualize
mouse
spine
during
inflammation
therapeutic
effect
resveratrol.
Chemical Communications,
Год журнала:
2024,
Номер
60(77), С. 10720 - 10723
Опубликована: Янв. 1, 2024
A
novel
approach
was
proposed
to
enhance
the
microviscosity
sensitivity
of
molecular
rotor
probes
by
integrating
flexible
rotators
and
expanded
frameworks,
addressing
crucial
challenge
weakening
in
dilute
solutions
macromolecules.
Abstract
Organelles
are
specialized
areas
where
cells
perform
specific
processes
necessary
for
life
and
actively
communicate
with
each
other
to
keep
the
whole
cell
functioning.
Disorders
of
organelle
networks
associated
multiple
pathological
processes.
However,
clearly
intuitively
visualizing
highly
dynamic
interactions
between
ultrafine
organelles
is
challenging.
Fluorescence
imaging
technology
provides
opportunities
due
distinct
advantages
facile,
non‐invasiveness
detection,
making
it
particularly
well‐suited
applications
in
uncovering
mysterious
veil
interactions.
Regrettably,
lack
ideal
fluorescence
agents
has
always
been
an
obstacle
intricate
behaviors
organelles.
In
this
review,
we
provide
a
systematic
discussion
on
existing
dual‐color
dual‐targetable
molecular
sensors
used
monitoring
interactions,
focus
their
targeting
strategies,
mechanisms
biological
applications.
Additionally,
current
limitations
future
development
directions
probes
dual‐emissives
briefly
discussed.
This
review
aims
guidance
researchers
develop
more
improved
studying
biomedical
field.
Abstract
As
a
high
reactive
oxygen
species
(ROS)
and
nitrogen
(RNS),
peroxynitrite
anion
(ONOO
−
)
is
widely
present
in
organisms
plays
influential
roles
physiological
pathological
processes.
It
of
great
significance
to
develop
effective
fluorescent
probes
for
imaging
variation
living
systems.
Herein
we
novel
probe
TQC0
monitoring
ONOO
based
on
the
iminocoumarin
platform,
this
was
synthesized
by
knoevenagel
condensation
between
dihydropyridine‐salicylaldehyde
derivative
2‐benzothiazole‐acetonitrile,
subsequently
masked
with
boronate
moiety.
The
obtained
exhibited
signal‐to‐noise
ratio
(206‐fold)
quick
‘turn‐on’
response
(about
10
min)
selectivity
sensitivity.
Furthermore,
successfully
applied
cells
low
cytotoxicity.
Chemical Communications,
Год журнала:
2024,
Номер
60(60), С. 7773 - 7776
Опубликована: Янв. 1, 2024
An
ER/lysosome
dual-labeling
fluoroprobe
(DRHB)
was
developed,
allowing
for
tracking
of
ER
dynamics
and
ratiometric
imaging
lysosomal
polarity
during
ferroptosis.
Analytical Methods,
Год журнала:
2024,
Номер
17(3), С. 533 - 538
Опубликована: Дек. 10, 2024
The
superoxide
anion
(O2˙-)
is
a
vital
reactive
oxygen
species
(ROS)
and
participates
in
various
physiological
pathological
processes
organisms.
outbreak
of
O2˙-
the
endoplasmic
reticulum
(ER)
believed
to
be
closely
related
many
inflammatory
diseases.
In
this
work,
turn-on
type
ER-targeting
fluorescent
probe
ERO
was
rationally
designed
for
sensitive
selective
detection
O2˙-.
minimum
limit
concentration
about
3.3
×
10-7
M
aqueous
solution.
More
importantly,
has
minimal
biological
toxicity
can
effectively
target
ER
detect
macrophage
cells.
Resveratrol
natural
drug
anti-inflammatory
effects.
Through
fluorescence
monitoring
ERO,
it
found
that
there
an
acute
spondylitis
mice
resveratrol
reversed
increase.
Thus,
potential
become
favorable
diagnostic
tool
visualize
mouse
spine
during
inflammation
therapeutic
effect
resveratrol.
