Effects of Vitamin D, Melatonin, and Omega-3 Fatty Acids on Periodontal Health: A Narrative Review DOI Creative Commons
Dora Dragičević,

Nikolina Lešić,

Ivana Škrlec

и другие.

Dentistry Journal, Год журнала: 2025, Номер 13(4), С. 178 - 178

Опубликована: Апрель 20, 2025

Periodontitis is a chronic inflammatory disease characterized by the destruction of tooth-supporting structures, influenced immune system dysregulation, oxidative stress, and imbalances in bone metabolism. Given its multifactorial pathogenesis, bioactive compounds such as vitamin D, melatonin, omega-3 fatty acids have emerged potential adjuncts to periodontal therapy due their immunomodulatory, anti-inflammatory, antioxidative properties. This narrative review explores role these three supplements health, synergistic effects, existing research gaps, providing foundation for future studies on clinical applications. Vitamin D essential calcium homeostasis, remodeling, function. It modulates both innate adaptive responses, enhancing antimicrobial peptide production reducing cytokine expression. Omega-3 reduce pro-inflammatory eicosanoids while promoting synthesis pro-resolving lipid mediators, contributing preservation balance. Melatonin, known antioxidant osteogenic properties, supports remodeling stimulating osteoblast proliferation inhibiting osteoclast activity, also regulating circadian rhythms, which may influence oral health. Although show promising effects preclinical studies, significant knowledge gaps remain regarding optimal dosages, long-term efficacy, combined use, standardized treatment protocols. Further trials are necessary elucidate therapeutic value management, especially those focused mechanisms. Understanding mechanisms open new avenues adjunctive strategies therapy.

Язык: Английский

Effects of Vitamin D, Melatonin, and Omega-3 Fatty Acids on Periodontal Health: A Narrative Review DOI Creative Commons
Dora Dragičević,

Nikolina Lešić,

Ivana Škrlec

и другие.

Dentistry Journal, Год журнала: 2025, Номер 13(4), С. 178 - 178

Опубликована: Апрель 20, 2025

Periodontitis is a chronic inflammatory disease characterized by the destruction of tooth-supporting structures, influenced immune system dysregulation, oxidative stress, and imbalances in bone metabolism. Given its multifactorial pathogenesis, bioactive compounds such as vitamin D, melatonin, omega-3 fatty acids have emerged potential adjuncts to periodontal therapy due their immunomodulatory, anti-inflammatory, antioxidative properties. This narrative review explores role these three supplements health, synergistic effects, existing research gaps, providing foundation for future studies on clinical applications. Vitamin D essential calcium homeostasis, remodeling, function. It modulates both innate adaptive responses, enhancing antimicrobial peptide production reducing cytokine expression. Omega-3 reduce pro-inflammatory eicosanoids while promoting synthesis pro-resolving lipid mediators, contributing preservation balance. Melatonin, known antioxidant osteogenic properties, supports remodeling stimulating osteoblast proliferation inhibiting osteoclast activity, also regulating circadian rhythms, which may influence oral health. Although show promising effects preclinical studies, significant knowledge gaps remain regarding optimal dosages, long-term efficacy, combined use, standardized treatment protocols. Further trials are necessary elucidate therapeutic value management, especially those focused mechanisms. Understanding mechanisms open new avenues adjunctive strategies therapy.

Язык: Английский

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