Biochemia Medica,
Год журнала:
2023,
Номер
33(2), С. 123 - 131
Опубликована: Апрель 12, 2023
Clinical
laboratory
practice
represents
an
essential
part
of
clinical
decision-making,
as
it
influences
60-70%
medical
decisions
at
all
levels
health
care.
Results
biochemical
tests
(BLTs)
have
a
key
role
in
establishment
adequate
diagnosis
well
evaluation
treatment
progress
and
outcome.
The
prevalence
drug-laboratory
test
interactions
(DLTIs)
is
up
to
43%
patients
who
had
results
influenced
by
drugs.
Unrecognized
DLTIs
may
lead
misinterpreted
BLTs
results,
incorrect
or
delayed
diagnosis,
extra
costs
for
unnecessary
additional
inadequate
therapy,
cause
false
decisions.
significance
timely
recognition
prevent
common
consequences
such
incorrectly
interpreted
non-treated
condition
due
erroneous
therapy.
Medical
professionals
should
be
educated
that
obtain
patient
data
about
medications
especially
the
drugs
used
last
10
days
before
biological
material
collection.
Our
mini-review
aims
provide
comprehensive
overview
current
state
this
important
domain
biochemistry
with
detailed
analysis
effect
on
give
information
specialists.
Clinical Interventions in Aging,
Год журнала:
2022,
Номер
Volume 17, С. 235 - 244
Опубликована: Март 1, 2022
To
investigate
the
association
between
polypharmacy,
anxiety,
and
depression
among
Chinese
older
adults.The
data
used
in
this
study
were
from
Longitudinal
Healthy
Longevity
Survey
(CLHLS),
2018
wave.
Polypharmacy
status
was
measured
by
accumulation
of
self-reported
medications.
Anxiety
assessed
Generalized
Disorder
(GAD-7)
scale
Center
for
Epidemiologic
Studies
Depression
Scale
(CES-D-10),
respectively.
Logistic
regression
models
performed.A
total
2484
adults
(female:
1321,
53.2%)
aged
60
to
117
years
old
included
analysis.
Regression
analysis
showed
that
polypharmacy
associated
with
after
controlling
covariates.
No
observed
anxiety.There
a
suggestive
link
adults.
Having
might
be
an
indicator
possible
population,
but
comprehensive
assessment
is
necessary.
British Journal of Clinical Pharmacology,
Год журнала:
2022,
Номер
89(2), С. 687 - 698
Опубликована: Авг. 30, 2022
The
drug
burden
index
(DBI)
measures
a
person's
total
exposure
to
anticholinergic
and
sedative
medications,
which
are
commonly
associated
with
harm.
Through
incorporating
the
DBI
in
electronic
medical
records
(eMR)
implementing
stewardship
program,
we
aimed
determine
(i)
uptake
of
steward's
recommendations
deprescribe
and/or
drugs
by
team
(ii)
whether
accepted
were
actioned
hospital
or
recommended
for
follow-up
General
Practitioner
post-discharge.
Clinical
evidence
demonstrating
a
longitudinal
association
between
prescribed
medications
and
sarcopenia
onset
is
lacking.
We
investigated
the
of
polypharmacy
(the
use
five
or
more
medications)
potentially
inappropriate
(PIMs)
with
risk
in
community-dwelling
older
adults.In
this
population-based
cohort
study,
2,044
residents
no
long-term
care
needs
were
randomly
selected
from
community
Kashiwa,
Japan.
Baseline
data
collection
was
conducted
2012,
follow-ups
2013,
2014,
2016,
2018,
2021.
Prescribed
PIMs
(drugs
listed
Screening
Tool
for
Older
Person's
Appropriate
Prescriptions
Japanese
muscle-wasting
drugs)
identified
through
interviews.
New-onset
according
to
2019
criteria
Asian
Working
Group
Sarcopenia
over
9-year
period
analyzed.
used
Cox
proportional
hazards
models
test
onset.Of
1,549
participants
without
at
baseline
(mean
age,
72.5
±
5.5
years;
49.1%
women;
median
interquartile
range,
6.0
[4.0-9.0]
years),
230
experienced
new-onset
during
follow-up.
After
adjusting
confounders,
combined
PIM
strongly
associated
(adjusted
hazard
ratio,
2.35;
95%
confidence
interval,
1.58-3.51;
P
<
0.001).
No
significant
associations
observed
either
alone.Polypharmacy
use,
but
not
alone,
an
increased
follow-up
among
adults.
Limiting
imposing
prescription
appropriate
may
facilitate
prevention.
Drugs & Aging,
Год журнала:
2023,
Номер
41(1), С. 1 - 11
Опубликована: Окт. 21, 2023
Older
adults
are
at
an
increased
risk
of
drug-related
problems,
especially
following
discharge
from
hospital.
Drug-related
readmissions
place
a
large
burden
on
the
patient
and
healthcare
system.
However,
previous
studies
report
inconsistent
results
prevalence
associated
factors
for
hospital
in
older
adults.
Biochemia Medica,
Год журнала:
2023,
Номер
33(2), С. 123 - 131
Опубликована: Апрель 12, 2023
Clinical
laboratory
practice
represents
an
essential
part
of
clinical
decision-making,
as
it
influences
60-70%
medical
decisions
at
all
levels
health
care.
Results
biochemical
tests
(BLTs)
have
a
key
role
in
establishment
adequate
diagnosis
well
evaluation
treatment
progress
and
outcome.
The
prevalence
drug-laboratory
test
interactions
(DLTIs)
is
up
to
43%
patients
who
had
results
influenced
by
drugs.
Unrecognized
DLTIs
may
lead
misinterpreted
BLTs
results,
incorrect
or
delayed
diagnosis,
extra
costs
for
unnecessary
additional
inadequate
therapy,
cause
false
decisions.
significance
timely
recognition
prevent
common
consequences
such
incorrectly
interpreted
non-treated
condition
due
erroneous
therapy.
Medical
professionals
should
be
educated
that
obtain
patient
data
about
medications
especially
the
drugs
used
last
10
days
before
biological
material
collection.
Our
mini-review
aims
provide
comprehensive
overview
current
state
this
important
domain
biochemistry
with
detailed
analysis
effect
on
give
information
specialists.
