The Balance of MFN2 and OPA1 in Mitochondrial Dynamics, Cellular Homeostasis, and Disease DOI Creative Commons
Paola Zanfardino, Alessandro Amati,

M Perrone

и другие.

Biomolecules, Год журнала: 2025, Номер 15(3), С. 433 - 433

Опубликована: Март 18, 2025

Mitochondrial dynamics, governed by fusion and fission, are crucial for maintaining cellular homeostasis, energy production, stress adaptation. MFN2 OPA1, key regulators of mitochondrial fusion, play essential roles beyond their structural functions, influencing bioenergetics, intracellular signaling, quality control mechanisms such as mitophagy. Disruptions in these processes, often caused or OPA1 mutations, linked to neurodegenerative diseases like Charcot-Marie-Tooth disease type 2A (CMT2A) autosomal dominant optic atrophy (ADOA). This review explores the molecular underlying impact dysfunction on oxidative phosphorylation autophagy, role progression. Additionally, we discuss divergent responses particularly terms proliferation, senescence, metabolic signaling. Finally, highlight emerging therapeutic strategies restore integrity, including mTOR modulation autophagy-targeted approaches, with potential implications disorders.

Язык: Английский

The Balance of MFN2 and OPA1 in Mitochondrial Dynamics, Cellular Homeostasis, and Disease DOI Creative Commons
Paola Zanfardino, Alessandro Amati,

M Perrone

и другие.

Biomolecules, Год журнала: 2025, Номер 15(3), С. 433 - 433

Опубликована: Март 18, 2025

Mitochondrial dynamics, governed by fusion and fission, are crucial for maintaining cellular homeostasis, energy production, stress adaptation. MFN2 OPA1, key regulators of mitochondrial fusion, play essential roles beyond their structural functions, influencing bioenergetics, intracellular signaling, quality control mechanisms such as mitophagy. Disruptions in these processes, often caused or OPA1 mutations, linked to neurodegenerative diseases like Charcot-Marie-Tooth disease type 2A (CMT2A) autosomal dominant optic atrophy (ADOA). This review explores the molecular underlying impact dysfunction on oxidative phosphorylation autophagy, role progression. Additionally, we discuss divergent responses particularly terms proliferation, senescence, metabolic signaling. Finally, highlight emerging therapeutic strategies restore integrity, including mTOR modulation autophagy-targeted approaches, with potential implications disorders.

Язык: Английский

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