Numerical study of magnetic nanoparticles injection into a brain tumor considering the effects of injection volume and location on the termination of cancerous cells DOI
Adeleh Kazemi Alamouti, Izaz Raouf, Saeed Zahabi

и другие.

Biointerphases, Год журнала: 2024, Номер 19(6)

Опубликована: Ноя. 1, 2024

Lately, magnetic nanoparticle (MNP) hyperthermia gained much attention because of its therapeutic efficiency. It is challenging to predict all the treatment parameters during actual environment. Hence, numerical approaches can be utilized optimize various interest. In present research, MNP on a cancerous tumor placed inside human brain investigated numerically using realistically shaped model for head layers and tumor. Applying boundary conditions, steady-state Pennes’s bioheat transfer equation solved finite element method scheme. The effects injection volume location thermal distribution are examined discussed in detail. total 5990 mm3. Three different volumes per point, namely, 0.6, 1.2, 3 μl, as well several points, performed. observed that choosing higher number points affects temperature terms uniformity. contrast, an accurate provides lower temperatures tissue. Moreover, it concluded interfaces between anatomically correct play critical role therapy. Based obtained results, optimal condition with mm3 80 μl through 20 over considering 4 each point.

Язык: Английский

Numerical study of magnetic nanoparticles injection into a brain tumor considering the effects of injection volume and location on the termination of cancerous cells DOI
Adeleh Kazemi Alamouti, Izaz Raouf, Saeed Zahabi

и другие.

Biointerphases, Год журнала: 2024, Номер 19(6)

Опубликована: Ноя. 1, 2024

Lately, magnetic nanoparticle (MNP) hyperthermia gained much attention because of its therapeutic efficiency. It is challenging to predict all the treatment parameters during actual environment. Hence, numerical approaches can be utilized optimize various interest. In present research, MNP on a cancerous tumor placed inside human brain investigated numerically using realistically shaped model for head layers and tumor. Applying boundary conditions, steady-state Pennes’s bioheat transfer equation solved finite element method scheme. The effects injection volume location thermal distribution are examined discussed in detail. total 5990 mm3. Three different volumes per point, namely, 0.6, 1.2, 3 μl, as well several points, performed. observed that choosing higher number points affects temperature terms uniformity. contrast, an accurate provides lower temperatures tissue. Moreover, it concluded interfaces between anatomically correct play critical role therapy. Based obtained results, optimal condition with mm3 80 μl through 20 over considering 4 each point.

Язык: Английский

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