Hybrid 3D Bioprinting of Sustainable Biomaterials for Advanced Multiscale Tissue Engineering

Small, Год журнала: 2025, Номер unknown

Опубликована: Март 27, 2025

Abstract 3D printing has greatly improved the precision of cell and biomaterial placement, enabling accurate reproduction tissue models with sustainable potential. Various techniques, including inkjet printing, extrusion‐based vat photopolymerization, offer unique advantages but often fail to replicate full complexity native tissues because material scalability limitations. Hybrid bioprinting, combining multiple techniques in a single process, shown great potential creating complex multifunctional capabilities, ranging from patient‐specific implant fabrication full‐scale organ development. It capitalizes on strengths integration sustainable, renewable biomaterials at varying resolutions, nano microscale. This approach addresses both biological environmental responsibility by minimizing waste enhancing sustainability engineering processes. Despite progress, substantial gap remains between current technologies bioengineering requirements. A deep understanding hybrid its underlying mechanisms is crucial. Herein, this review summarizes discusses recent advancements systems for fabricating multiscale hierarchical models, focusing challenges field. aims insights identify key requirements advancing technology toward developing functional, biomimetic constructs.

Язык: Английский

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A Novel Tumor on Chip Mimicking the Breast Cancer Microenvironment for Dynamic Drug Screening

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1028 - 1028

Опубликована: Янв. 25, 2025

In light of the emerging breakthroughs in cancer biology, drug discovery, and personalized medicine, Tumor-on-Chip (ToC) platforms have become pivotal tools current biomedical research. This study introduced a novel rapid prototyping approach for fabrication ToC device using laser-patterned poly(methyl methacrylate) (PMMA) layers integrated with polylactic acid (PLA) electrospun scaffold, enabling dynamic delivery assessment therapeutic efficacy cells. Traditional screening methods, such as conventional cell cultures, mimic certain aspects progression but fail to capture critical features tumor microenvironment (TME). While animal models offer closer approximation complexity, they are limited their ability predict human responses. Here, we evaluated our recapitulate interactions between TME cells its evaluating response breast The functional design proposed system offered substantial potential wide range applications research, significantly accelerating preclinical new agents.

Язык: Английский

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Silk fibroin electrospun scaffolds with sustained dual release of growth factors enhance acute liver failure treatment

Composites Part B Engineering, Год журнала: 2025, Номер unknown, С. 112260 - 112260

Опубликована: Фев. 1, 2025

Язык: Английский

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Rational Construct of Extracellular Matrix Mimics via Peptide-Co-assembling Nanofibers for Efficient Bone Regeneration

Advanced Fiber Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

Язык: Английский

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