Herbal Treatments and Their Impact on Male Fertility: A Comprehensive Review
Опубликована: Янв. 7, 2025
Male
fertility
is
increasingly
recognized
as
a
critical
aspect
of
overall
male
health
and
influenced
by
genetic,
lifestyle,
environmental
factors.
It
biological
marker
for
various
conditions
including
oncological,
cardiovascular,
autoimmune
diseases.
Understanding
can
provide
insights
into
broader
issues,
emphasizing
the
need
multidisciplinary
approach
to
healthcare.
This
review
aimed
analyze
existing
evidence
on
mechanisms
effects
herbal
treatments
fertility.
underscores
importance
rigorous
clinical
trials
quality
control
ensure
safe
application
these
remedies.
narrative
concentrated
English-language
literature
encompassing
research
studies,
case
reports,
systematic
reviews,
meta-analyses.
Comprehensive
searches
were
conducted
across
databases
such
PubMed,
Scopus,
Google
Scholar,
employing
keywords
"Male
Fertility,
Herbal
Medicine,
Reproductive
Health,
Plant
Extracts,
Complementary
Therapies".
To
inclusion
most
recent
findings,
filters
applied
select
studies
published
in
English
between
1995
December
2024.
highlights
that
lifestyle
choices,
diet
substance
use,
significantly
impact
fertility,
while
pollutants
medications
also
pose
risks.
infertility
treatments,
vitro
fertilization
(IVF)
hormonal
therapies,
often
face
challenges
related
cost,
complexity,
side
effects.
Many
conventional
therapies
lack
robust
scientific
support,
which
necessitates
ongoing
research.
medicines,
have
long
history
cultures,
are
gaining
popularity
complementary
options
enhance
Herbs
maca
ginseng
shown
potential
improve
sperm
count,
primarily
due
their
antioxidant
properties.
However,
efficacy
safety
requires
further
validation.
Overall,
offer
promising
benefits,
they
should
be
used
cautiously
conjunction
with
holistic
addressing
infertility.
The
ultimate
goal
empower
couples
informed
choices
regarding
treatments.
Язык: Английский
Evaluation of male contraceptive efficacy of Caesalpinia pulcherrima (L.) sw. in human and rat: an ex-vivo study
Pampa Lohar,
Dibya Pal,
Tanusree Mondal
и другие.
Systems Biology in Reproductive Medicine,
Год журнала:
2025,
Номер
71(1), С. 43 - 53
Опубликована: Фев. 19, 2025
The
study
focused
on
the
spermicidal
and
anti-androgenic
effects
of
aqueous-ethanolic
(60:40)
extract
Caesalpinia
pulcherrima
leaves
(AEECPL)
in
human
rat
samples
from
viewpoint
its
contraceptive
efficacy
through
ex-vivo
study.
Six
fertile
adult
males
were
selected
randomly
for
semen
collection.
Parallelly
sperm
collected
by
epididymal
washing
six
rats.
Testes,
epididymis,
liver
dissected
Biological
divided
into
control,
1,
2,
4
mg/ml
AEECPL
exposed
groups.
Relevant
spermiological,
steroidogenic
enzymes,
oxidative
stress,
metabolic
toxicity
sensors
evaluated.
All
spermiological
decreased
significantly
dose
duration-dependent
manners,
number
comet
positive
spermatozoa
increased
dose-dependent
mode
groups
against
control
both
rat.
Activities
Δ5,3β-hydroxysteroid
dehydrogenase
(HSD),
17β-HSD
testis,
kinetics
superoxide
dismutase
testis
epididymis
along
with
elevation
level
thiobarbituric
acid
reactive
substances
glutamate
oxaloacetate
transaminase,
pyruvate
phosphatase,
alkaline
phosphatase
above
mentioned
tissues
showed
no
significant
difference
among
groups,
indicating
non-toxic
reproductive
tissues.
results
presenting
prominent
preventing
potentiality
said
optimal
effect
was
noted
at
2
dose.
In-depth
investigations
are
required
in-vivo
studies
animal
model
to
know
genomic
action
execution
male
activity.
Язык: Английский
Herbal Treatments and Their Impact on Male Fertility: A Comprehensive Review
Qeios,
Год журнала:
2025,
Номер
7(3)
Опубликована: Март 11, 2025
Male
fertility
is
increasingly
recognized
as
a
critical
aspect
of
overall
male
health
and
influenced
by
genetic,
lifestyle,
environmental
factors.
It
biological
marker
for
various
conditions
including
oncological,
cardiovascular,
autoimmune
diseases.
Understanding
can
provide
insights
into
broader
issues,
emphasizing
the
need
multidisciplinary
approach
to
healthcare.
This
review
aimed
analyze
existing
evidence
on
mechanisms
effects
herbal
treatments
fertility.
underscores
importance
rigorous
clinical
trials
quality
control
ensure
safe
application
these
remedies.
narrative
concentrated
English-language
literature
encompassing
research
studies,
case
reports,
systematic
reviews,
meta-analyses.
Comprehensive
searches
were
conducted
across
databases
such
PubMed,
Scopus,
Google
Scholar,
employing
keywords
"Male
Fertility,
Herbal
Medicine,
Reproductive
Health,
Plant
Extracts,
Complementary
Therapies".
To
inclusion
most
recent
findings,
filters
applied
select
studies
published
in
English
between
1995
December
2024.
highlights
that
lifestyle
choices,
diet
substance
use,
significantly
impact
fertility,
while
pollutants
medications
also
pose
risks.
infertility
treatments,
vitro
fertilization
(IVF)
hormonal
therapies,
often
face
challenges
related
cost,
complexity,
side
effects.
Many
conventional
therapies
lack
robust
scientific
support,
which
necessitates
ongoing
research.
medicines,
have
long
history
cultures,
are
gaining
popularity
complementary
options
enhance
Herbs
maca
ginseng
shown
potential
improve
sperm
count,
primarily
due
their
antioxidant
properties.
However,
efficacy
safety
requires
further
validation.
Overall,
offer
promising
benefits,
they
should
be
used
cautiously
conjunction
with
holistic
addressing
infertility.
The
ultimate
goal
empower
couples
informed
choices
regarding
treatments.
Язык: Английский
Protective Effect of Aloe vera (L.) on Diabetes-Induced Oxidative Stress Linked Spermiological Co-Morbidity in Human and Rat: An In-Vitro Analysis
Reproductive Sciences,
Год журнала:
2024,
Номер
31(9), С. 2685 - 2699
Опубликована: Июнь 6, 2024
Язык: Английский
Pharmacokinetics and tissue distribution of LN002, a new compound alternative oxidase inhibitor against Cryptosporidium in rats
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 30, 2024
Cryptosporidiosis
is
considered
a
crucial
zoonotic
disease
caused
by
widely
distributing
parasitic
protozoa
called
Язык: Английский
Hypo-testicular Efficacy Assessment of H<sub>2</sub>O-methanol (60:40) Extract of Tinospora cordifolia (Willd.) Stem in Albino Rat: A Dose-dependent Study
Advances in Pharmacology and Pharmacy,
Год журнала:
2024,
Номер
12(2), С. 104 - 115
Опубликована: Фев. 4, 2024
Язык: Английский
Pre-clinical study on hypo-testicular activity of hydro-ethanol (60:40) extract of Areca catechu (L.) in albino rat: Dose-dependent response
Sukriti Hazra,
Dibya Pal,
Puja Das
и другие.
International Journal of Ayurvedic Medicine,
Год журнала:
2024,
Номер
15(2), С. 480 - 489
Опубликована: Июль 10, 2024
The
study
focused
to
assess
the
dose-dependent
hypo-testicular
activity
of
hydro-ethanol
seed
extract
Areca
catechu
(10,
20
and
40
mg/
100
g
body
weight)
in
albino
rats.
For
this
purpose,
weight,
reproductive
organo-somatic
indices,
as
well
motility,
count,
hypo-osmotic
swelling
acrosomal
cap
status
sperm
along
with
quantity
testicular
androgenic
key
enzyme
activities,
serum
testosterone,
oxidative
stress
sensors,
seminal
vesicular
fructose
(SVF),
apoptosis
linked
gene
expression
histology
tissue
for
spermatokinetics
were
covered
here.
All
said
doses
revealed
a
significant
(p<0.05)
downward
deviation
spermiological
profile,
SVF
levels,
activities
∆5,3β
17β-HSD,
seminiferous
tubular
diameter
compared
vehicle-treated
control
(VTC).
In
contrast
VTC,
superoxide
dismutase
peroxidase
decreased
elevation
levels
thio-barbituric
acid
reactive
substances
significantly
testis
pellet
extract-treated
groups.
Testicular
pro-apoptotic
Bax
was
elevated
anti-apoptotic
Bcl-2
diminished
after
treatment
VTC.
Non-significant
changes
(p>0.05)
noted
hepatic
alkaline
phosphatase
which
non-toxic
characteristics
general.
This
interpreted
that,
mg
showed
drastic
efficacy
cum
necrotic
other
though
therapeutic
dose
that
cross
borderline
fertile
sensors
from
indicators
is
dose.
Liquid
chromatography-mass
spectrometry
analysis
ten
phyto-molecules
belong
flavonoid,
alkaloid
isoflavone
groups
mainly.
Язык: Английский