Supplementation with specific branched-chain amino acids (BCAAs) affects mouse sperm parameters and testicular apoptotic gene expression DOI

Roya Kamali,

Leila Rashki Ghaleno, Amin Izadi

и другие.

Zygote, Год журнала: 2025, Номер unknown, С. 1 - 9

Опубликована: Май 13, 2025

Summary In Western diets, high consumption of meat and dairy products, known to be rich in branched-chain amino acids (BCAAs), including leucine (Leu), isoleucine (Ile), valine (Val), as well BCAAs supplementation itself, may have unforeseen consequences on sperm quality. addition, bodybuilders are increasingly resorting BCAA build-up their muscle mass. This study aimed assess the effect dietary BCAAs, provided alone or combination, semen parameters, apoptotic gene expression, blood acid (AA) profiles. To address this question determine whether these different a distinct impact quality testicular homeostasis, fifty NMRI mature male mice were exposed not supplementations (control diet: CTR; CTR + Leu supplementation; Ile Val all three supplementation). Only resulted significant decrease concentration viability. only was associated with dramatic increase immotility. The Bax/Bcl2 ratio, an indicator apoptosis, found significantly higher testes BCAA-supplemented animals when compared other groups. Caspase3 expression also Val-supplemented animals. There no differences plasma AA profiles between Thus, amongst appears carry greatest functional parameters status.

Язык: Английский

Dietary valine affects Japanese quails’ sperm parameters and testis histology DOI Creative Commons

Zahra Dinari,

Abouzar Najafi, Seyed Davood Sharifi

и другие.

Poultry Science, Год журнала: 2025, Номер 104(7), С. 105181 - 105181

Опубликована: Апрель 23, 2025

Valine is an essential amino acid that participates in various physiological and metabolic activities. The objective of the present study was to investigate influence different valine levels diet on reproductive performance adult male Japanese quails. Forty quail chicks (14-24 week old) were employed a completely randomized design with 5 treatments (0.65, 0.75, 0.85, 0.95, 1.05 % diet), 4 replicates 2 birds each replicate over period 35 days following 14-day adaptation period. Semen collected weekly, its characteristics analyzed. then ethically slaughtered, histological analyses performed testicular samples. Results showed had no significant effect testicle volume, length relative weight, although diameter tended decrease increasing level linear quadratic manner (p < 0.05). total motility progressive sperm decreased increase dietary Abnormal morphology increased difference between significant. Different significantly affected height seminiferous tubule epithelia, number tubules as well tubular differentiation index testis; but spermatogenic not by treatments. findings indicate when exceed 0.75 %, there adverse impact volume diameter, qualitative properties It advisable pursue additional research this area.

Язык: Английский

Процитировано

1

Supplementation with specific branched-chain amino acids (BCAAs) affects mouse sperm parameters and testicular apoptotic gene expression DOI

Roya Kamali,

Leila Rashki Ghaleno, Amin Izadi

и другие.

Zygote, Год журнала: 2025, Номер unknown, С. 1 - 9

Опубликована: Май 13, 2025

Summary In Western diets, high consumption of meat and dairy products, known to be rich in branched-chain amino acids (BCAAs), including leucine (Leu), isoleucine (Ile), valine (Val), as well BCAAs supplementation itself, may have unforeseen consequences on sperm quality. addition, bodybuilders are increasingly resorting BCAA build-up their muscle mass. This study aimed assess the effect dietary BCAAs, provided alone or combination, semen parameters, apoptotic gene expression, blood acid (AA) profiles. To address this question determine whether these different a distinct impact quality testicular homeostasis, fifty NMRI mature male mice were exposed not supplementations (control diet: CTR; CTR + Leu supplementation; Ile Val all three supplementation). Only resulted significant decrease concentration viability. only was associated with dramatic increase immotility. The Bax/Bcl2 ratio, an indicator apoptosis, found significantly higher testes BCAA-supplemented animals when compared other groups. Caspase3 expression also Val-supplemented animals. There no differences plasma AA profiles between Thus, amongst appears carry greatest functional parameters status.

Язык: Английский

Процитировано

0