Cannabidiol and epilepsy
International review of neurobiology,
Год журнала:
2024,
Номер
unknown, С. 135 - 147
Опубликована: Янв. 1, 2024
Язык: Английский
Cannabidiol Anticonvulsant Effects Against Lithium-Pilocarpine-Induced Status Epilepticus in Male Rats Are Mediated by Neuroinflammation Modulation and Cannabinoids 1 (CB1), But Not CB2 and GABAA Receptors
Cannabis and Cannabinoid Research,
Год журнала:
2023,
Номер
9(3), С. 797 - 808
Опубликована: Ноя. 17, 2023
Background:
Status
epilepticus
(SE)
is
a
series
of
seizures
that
can
lead
to
serious
neurological
damages.
Cannabidiol
(CBD)
extracted
from
the
cannabis
plant,
which
has
been
approved
as
an
antiseizure
medication.
This
study
aimed
determine
efficacy
various
doses
CBD
on
lithium-pilocarpine-induced
SE
in
rats
and
possible
involvement
multiple
pharmacological
pathways.
We
hypothesized
cannabinoid
receptors
type
1
(CB1)
CB2,
well
GABAA
receptors,
might
have
important
roles
anticonvulsant
effects
against
by
its
anti-inflammatory
effects.
Methods:
was
induced
intraperitoneal
(i.p.)
injection
lithium
(127
mg/kg,
i.p.)
pilocarpine
(60
i.p.,
20
h
after
lithium).
Forty-two
male
were
divided
into
seven
groups
(including
control
sham
groups),
treated
received
different
(1,
3,
5,
10,
25
i.p.).
score
recorded
over
next
2
following
injection.
Then,
we
measured
levels
pro-inflammatory
cytokines,
including
interleukin
(IL)-lβ
tumor
necrosis
factor
(TNF)-α,
using
ELISA
kits.
Also
analyzed
expression
CB1,
Western
blot
technique.
Results:
at
5
mg/kg
significantly
reduced
Racine's
scale
duration
seizures,
increased
onset
time
seizure.
Moreover,
caused
significant
reductions
elevated
IL-lβ
TNF-α,
increase
decreased
level
CB1
receptor
compared
group.
In
other
word,
reverted
terms
neuroinflammation
receptor.
Based
obtained
results,
not
able
restore
declined
CB2
or
receptors.
Conclusion:
Our
found
rat
model
lithium-pilocarpine
with
probable
reducing
IL-1β
TNF-α
markers
independent
Язык: Английский
Metformin Improves Spatial Memory and Reduces Seizure Severity in a Rat Model of Epilepsy and Alzheimer’s Disease comorbidity via PI3K/Akt Signaling Pathway
Suélen Santos Alves,
Letícia Rossi,
José Antônio Cortes de Oliveira
и другие.
Molecular Neurobiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 24, 2025
Язык: Английский
The role of the endocannabinoid system in the pathogenesis and treatment of epilepsy
Reviews in the Neurosciences,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 11, 2024
Epilepsy
is
a
group
of
chronic
neurological
brain
disorders
characterized
by
recurrent
spontaneous
unprovoked
seizures,
which
are
accompanied
significant
neurobiological,
cognitive,
and
psychosocial
impairments.
With
global
prevalence
approximately
0.5-1
%
the
population,
epilepsy
remains
serious
public
health
concern.
Despite
development
widespread
use
over
20
anticonvulsant
drugs,
around
30
patients
continue
to
experience
drug-resistant
leading
substantial
reduction
in
quality
life
increased
mortality
risk.
Given
limited
efficacy
current
treatments,
exploring
new
therapeutic
approaches
critically
important.
In
recent
years,
Gi-protein-coupled
receptors,
particularly
cannabinoid
receptors
CB1
CB2,
have
garnered
increasing
attention
as
promising
targets
for
treatment
seizures
prevention
epilepsy.
Emerging
evidence
suggests
role
system
modulating
neuronal
activity
protecting
against
hyperexcitability,
underscoring
importance
further
research
this
area.
This
review
provides
up-to-date
insights
into
pathogenesis
epilepsy,
with
special
focus
on
system,
highlighting
need
continued
investigation
develop
more
effective
strategies.
Язык: Английский